Natural Products

Chicoric acid is a caffeic acid derivative, belonging to the group of polypfenols. Chicoric acid is the most active compound in Echinacea pupurea. Chicoric acid is very stable in dry conditions but can be broken down by enzymes, which are found in the Echinacea, in moist conditions.

Chimaphilin is extracted from pyrola [Passiflora incarnata Fisch.] Chimaphilin could inhibit the viability of MCF-7 cells in a concentration-dependent manner, and the IC50 value was 43.30μM for 24h.

Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain

Nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Corosolic acid is a pentacyclic triterpene acid, found in Lagerstroemia speciosa, used in dietary supplements as a glucose-lowering agent and insulin mimetic.

4-O-Caffeoylquinic acid, also known as cryptochlorogenic acid, is an isomer of chlorogenic acid and possesses antioxidant properties.

Echinacoside was shown to promote proliferation of intestinal epithelial cells by increasing TGF-β1 expression.

Syringin is a natural chemical compound first isolated from the bark of lilac (Syringa vulgaris) by Meillet in 1841.

Eleutheroside E(EE) has anti-inflammatory and protective effects in ischemia heart, the beneficial effect of EE may provide an effective and powerful strategy to alleviate behavioral alterations induced by sleep deprivation, it may influence to immune-enhancing through increasing the physical endurance capacity and immune cell activation. EE significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the generation of TNF-α and IL-6, the metabolism of drugs metabolized via CYP2C9 and CYP2E1.

(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1

(-)Epicatechin gallate is a polyphenol apoptosis inducer in tumor cells commonly found in green tea.

(-)-Epigallocatechin is a major green tea polyphenol with antioxidant, anti-inflammatory, and anticancer activities.

Eriocitrin is a flavone glycoside found in lemon. Administration prior to acute exercise helped to maintain the redox status of liver glutathione.

Eriodictyol is a bitter-masking flavanone, a flavonoid extracted from Yerba Santa (Eriodictyon californicum), a plant native to North America.

Gallocatechin gallate is the ester of gallocatechin and gallic acid and a type of catechin. It is am antioxidant.

gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.

Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.

Glabridin is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra). Glabridin is an isoflavane, a type of isoflavonoid. Glabridin has also been studied as a health ingredient. Studies have show positive effects in fields like LDL protection against oxidation and anti-obesity.

Glycitein is an O-methylated isoflavone which accounts for 5-10% of the total isoflavones in soy food products.

Glycitin is a natural isoflavone isolated from legumes, including soy and kudzu.

Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort). It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC50 of about 10 ug/ml. Hyperforin is also a ligand for the steroid X receptor (SXR).

Hypericin is a photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort).

Hyperoside protects against peroxide-induced oxidative damage to cells by scavenging reactive oxygen species and enhancing activity of anti-oxidant enzymes, in particular, catalase and glutathione peroxidase.

Isoacteoside is a natural compound which exhibit significant inhibition of advanced glycation end product formation with IC50 values of 4.6-25.7 μM, compared with those of aminoguanidine (IC50=1,056 μM) and quercetin (IC50=28.4 μM) as positive controls.

Botanical Source: globe artichoke (Cynara scolymus), quince fruit (Cydonia oblonga), Caucasian whortleberry (Vaccinium arctostaphylos), Aster scaber and Ipomoea batatas (sweet potato) tubers

Isochlorogenic acid B is derived from the flowerbud of Lonicera japonica Thunb.

Isochlorogenic acid B is derived from the flowerbud of Lonicera japonica Thunb.

Isoorientin is derived from the herb of Pedicularis striata Pall.

isoquercitrin is derived from rutin (quercetin-3-O-rhamnoglucoside), which is treated with acid to obtain quercetin. Rutin is isolated from the seed pods of the Brazilian shrub ??fava d?anta?? (Dimorphandra mollis). There is significant evidence in the literature concerning anti-proliferative and cell growth regulating properties of quercetin.

Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling.

Isosteviol has beneficial effects on palmitate-induced alpha-cell dysfunction and gene expression.

Isovitexin (or homovitexin, saponaretin) is a flavone. the apigenin-6-C-glucoside. It can be found in the passion flower and the a?a?? palm.

Jaceosidin is a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells.

Lathyrol is a natural product, and is used for cancer treatment.

Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist

Liquiritin is a flavonoid isolated from Glycyrrhiza, acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.

Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin and can be found in dandelion coffee, in Ferula varia and F. foetida in Campanula persicifolia and C. rotundifolia, in the bamboo Phyllostachys nigra and in Cynara scolymus (artichoke).

Madecassic acid has anti-inflammatory effects via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells

Madecassoside is a triterpenoid product isolated from Centella asiatica, has been described to exhibit antioxidant and anti-inflammatory activities.

Mangiferin has been shown to have the effect of improving dyslipidemia.

Maslinic Acid is a pentacyclic triterpene with antioxidant and anti-inflammatory properties. Studies indicate that Maslinic Acid blocks the generation of nitric oxide, and inhibits the secretion of IL-6 and TNF-?? induced by lipopolysaccharides. Maslinic Acid is described to have antiproliferative and anti-HIV properties.

Mogroside IV, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.

Mogroside V, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogroside V is nearly 300 times sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities. Mogrosides are sweeter than sucrose.

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Neochlorogenic acid is a natural polyphenolic compound found in some types dried fruits and a variety of other plant sources such as peach

Niranthin is a lignan isolated from the aerial parts of the plant Phyllanthus amarus, exhibits a wide spectrum of pharmacological activities.

Oleuropein is a phenylethanoid, a type of phenolic compound found in olive leaf from the olive tree together with other closely related compounds such as 10-hydroxyoleuropein, ligstroside, and 10-hydroxyligstroside.

Orientin is a flavone, a chemical flavonoid-like compound. It is the 8-C glucoside of luteolin

Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.

Procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products.