Catalog No.
Product Name
Application
Product Information
Citations
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Anti-atherosclerosis Agent
Paeonolsilate sodium is an anti-atherosclerosis agent that effectively inhibits oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and associated inflammation. This compound suppresses NF-κB activation and the oxidative stress response triggered by ox-LDL. Paeonolsilate sodium is a valuable reagent for studying mechanisms underlying atherosclerosis and exploring potential therapeutic strategies. -
NF-κB Inhibitor
Laurotetanine is a potent isoquinoline alkaloid functioning as an NF-κB inhibitor. It exhibits anti-asthmatic properties by modulating immune responses, specifically inhibiting IgE and histamine release, alongside reducing inflammatory reactions. Laurotetanine's mechanism involves the downregulation of MUC5AC and NF-κB signaling pathways, making it a valuable tool for research in inflammatory diseases and asthma therapy. -
NF-κB Inhibitor
Dauricinoline is a potent orally active inhibitor of NF-κB, effectively blocking NF-κB activation induced by TNF-α. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for investigating inflammatory diseases, particularly in the context of lung inflammation. Researchers may utilize Dauricinoline to explore the mechanisms underlying NF-κB-mediated signaling pathways and their role in various inflammatory conditions. -
NIK Inhibitor
NIK-IN-1 is a potent inhibitor of NF-κB-inducing kinase (NIK), a critical regulator in the NF-κB signaling pathway. This compound demonstrates significant anti-inflammatory activity and is utilized in research focused on hepatic inflammatory diseases and acute liver injury. Its application helps elucidate the role of NIK in liver pathology and potential therapeutic interventions. -
NF-κB Modulator
IMD-biphenylB is a potent NF-κB modulator known for its ability to inhibit tumor proliferation. This imidazoquinolinone dimer also demonstrates a capacity to induce low systemic inflammation and minimize adjuvant toxicity. It serves as a valuable tool for research focused on immune response modulation and cancer therapy development. -
NF-κB Pathway Inhibitor
Pterocenoid C is a potent inhibitor of the NF-κB signaling pathway. This compound demonstrates significant biological activity by modulating inflammatory responses and has potential applications in the study of diseases associated with NF-κB dysregulation, including cancer and autoimmune disorders. Pterocenoid C serves as a valuable tool for researchers investigating the intricate roles of NF-κB in various biological processes and disease mechanisms. -
NF-κB Inhibitor
mcIRBP-9 is an orally bioavailable NF-κB inhibitor that effectively reduces pro-inflammatory cytokines such as TNF-α, IL-1β, and TGF-β1 in renal tissues. Additionally, mcIRBP-9 decreases LPS-induced production of IL-1β, making it a valuable tool for studying inflammatory processes. This compound is relevant to research focused on diabetic nephropathy and type 2 diabetes mellitus, providing insights into the underlying mechanisms of these conditions. -
Anti-Inflammatory Agent
Goshonoside F5 is an anti-inflammatory agent derived from the unripe fruits of Rubus chingii. It demonstrates significant anti-inflammatory activity by inhibiting the NF-κB and MAPK signaling pathways. This compound is relevant for research applications focusing on inflammation-related conditions and the underlying molecular mechanisms. -
NF-κB Inhibitor
NF-κB-IN-17 is an NF-κB inhibitor that effectively suppresses TNF-α-induced NF-κB DNA binding activity in C2C12 cells. Its mechanistic action provides valuable insights into the modulation of inflammatory responses, making it a useful tool for research applications focused on immune regulation and cancer biology. This reagent is suitable for studies examining the NF-κB signaling pathway and its implications in various disease models. -
Amide Alkaloid
Coumaperine is an amide alkaloid known for its ability to inhibit NF-κB signaling pathways. This compound has demonstrated anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma, making it valuable for cancer research. Additionally, Coumaperine derivatives exhibit antibacterial properties, further expanding their potential applications in biomedical studies. -
NF-κB
ABD-350 is a selective inhibitor of NF-κB, primarily targeting the phosphorylation of the inhibitor of NF-κB. This compound demonstrates key antiresorptive activity by promoting osteoclast apoptosis while preserving osteoblast function, making it effective in preventing ovariectomy-induced bone loss. Its application includes studying osteoclast regulation and potential therapeutic strategies for osteoporosis without interfering with bone formation driven by parathyroid hormone. -
NF-κB Inhibitor
Avenanthramide-C methyl ester is an NF-κB inhibitor that exerts anti-inflammatory effects by inhibiting the secretion of pro-inflammatory factors. This compound blocks NF-κB activation through the inhibition of IKK and IκB phosphorylation, as well as by impairing proteasome activity. Avenanthramide-C methyl ester is valuable for research applications focused on inflammation and related signaling pathways. -
NF-κB Inhibitor
Coronalolic acid acts as an NF-κB inhibitor, derived from the apical bud of Gardenia sootepenesis Hutch. This compound effectively suppresses TNF-α-induced NF-κB activation and inhibits nitric oxide (NO) production. It serves as a valuable tool for research applications focused on inflammation and immune response modulation. -
NIK Inhibtior
AM-0561 is a potent NIK inhibitor with a Ki of 0.3 nM, effectively suppressing the activity of the non-canonical NF-κB signaling pathway. By inhibiting NIK, AM-0561 significantly reduces p52 protein levels, which may contribute to the regulation of various cellular processes. This reagent is useful for research applications aimed at understanding NF-κB signaling in inflammation, immune response, and cancer biology. -
Anticancer Agent
Antiproliferative Agent-76 is an 8-sulfonamidoquinoline derivative functioning as a selective anticancer agent. It effectively inhibits the NF-κB and WNT signaling pathways, promoting apoptosis in cancer cells. This compound demonstrates notable anticancer activity against colorectal cancer and leukemia, making it a valuable tool for cancer research and therapeutic applications. -
NF-κB Inhibitor
Myrcene-d6 functions as an NF-κB inhibitor through its deuterium labeling of the natural compound myrcene. With demonstrated efficacy in inhibiting TNFα and NF-κB activity, myrcene exhibits significant anti-invasive properties, mediates cell cycle arrest, and promotes apoptosis in cancer cells. Its biological activities also include robust blood protection and anti-inflammatory effects, making it a valuable reagent for research in cancer biology and inflammatory responses. -
NF-κB Modulator
IMD-vanillin is an NF-κB modulator that functions as a novel immunomodulatory compound derived from imidazoquinolinone dimers. This reagent has demonstrated the ability to inhibit NF-κB activation, thereby modulating inflammatory responses and influencing cell survival. IMD-vanillin is suitable for research applications focused on inflammation, autoimmune diseases, and cancer, where NF-κB pathways play a crucial role. -
Chlorinated Alkaloid
Dauricumine is a chlorinated alkaloid that functions as an inhibitor of NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. This compound is significant in research applications focused on bone metabolism and osteoclastogenesis, providing insights into the regulation of inflammatory responses and potential therapeutic approaches for bone-related disorders. -
Chromone Derivative
7-O-Methylaloesinol is a chromone derivative that exhibits notable inhibitory activity against TNFα-induced NF-κB transcriptional activation, with an IC50 value of 29.07 μM. This compound serves as a valuable tool for studying inflammatory pathways and the modulation of NF-κB signaling, contributing to research in cellular responses and potential therapeutic strategies for inflammatory diseases. -
NF-κB Inhibitor
NF-κB-IN-9 is a potent inhibitor of nuclear factor kappa B (NF-κB), functioning as a sonosensitizer with an excitation/emission wavelength of 489/628 nm. This compound exhibits significant inhibition of NF-κB signaling pathways, attributed to its dual resveratrol units. NF-κB-IN-9 demonstrates effective anti-tumor activity and exhibits pronounced sonocytotoxicity against various cancer cell lines. Additionally, NF-κB-IN-9 has shown favorable biosafety profiles in xenograft mouse models, making it a valuable tool for cancer research. -
NF-κB decoy oligonucleotide
Cupabimod is a decoy oligonucleotide designed to inhibit the transcription factor NF-κB. By sequestering NF-κB, it effectively modulates inflammatory responses and regulates gene expression associated with various diseases. This compound is utilized in research focused on inflammation, autoimmune disorders, and cancer, providing valuable insights into the role of NF-κB signaling pathways. -
NF-κB Inhibitor
Licoagrochalcone C is a flavonoid that serves as an effective inhibitor of NF-κB transcription. It demonstrates significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound is valuable for research applications focused on inflammatory responses and NF-κB-related signaling pathways. -
Anti-inflammatory Agent
Catalposide is an iridoid glycoside derived from Catalpa ovata G. Don (Bignoniaceae) that acts as an anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, as well as the activation of NF-κB (p65) in lipopolysaccharide-stimulated RAW 264.7 macrophages. This compound is valuable for research in inflammatory pathways and potential therapeutic interventions in inflammatory diseases. -
NF-κB Activator
oxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is an NF-κB activator that functions as a key ligand for β-glycoprotein I (β(2)-GPI), derived from oxidized low-density lipoprotein (oxLDL). By promoting nuclear translocation, oxLig-1 initiates the NF-κB signaling pathway, which plays a significant role in various inflammatory processes. This compound is instrumental in research on atherosclerosis and offers insights into the mechanisms underlying lipid metabolism and cardiovascular diseases. -
NF-κB Inhibitor
(R)-SEMBL is a potent inhibitor of the NF-κB signaling pathway. This compound exhibits significant biological activity in the modulation of inflammatory responses and has potential applications in cancer research, autoimmune diseases, and metabolic disorders such as diabetes. Additionally, (R)-SEMBL may be useful in investigating therapeutic strategies for cardiovascular diseases and complications associated with defective reperfusion injury. -
NF-κB Inhibitor
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene that acts as a nuclear factor kappa B (NF-κB) inhibitor. It effectively inhibits TNFα-triggered NF-κB activity with an IC50 of 8.7 μg/mL, demonstrating significant anti-inflammatory properties. Additionally, this compound reduces nitric oxide (NO) production and exhibits notable cytotoxic effects against tumor cells, making it a valuable tool for cancer and inflammation research. -
NF-κB Inhibitor
Sul-121 hydrochloride is a potent NF-κB inhibitor that effectively reduces airway inflammation and hyperresponsiveness in models of chronic obstructive pulmonary disease (COPD). This compound demonstrates a dose-dependent inhibition of lipopolysaccharide-induced airway neutrophilia and attenuates oxidative stress markers in human airway smooth muscle cells. By preventing the nuclear translocation of the NF-κB subunit p65, Sul-121 hydrochloride decreases the release of pro-inflammatory cytokines, making it a valuable tool for investigating inflammatory pathways in respiratory diseases. -
NF-κB Inhibitor
OT-551 is a selective NF-κB inhibitor that exhibits both antioxidant and anti-inflammatory properties. This compound is utilized in research focused on retinal diseases, providing a valuable tool for exploring the mechanisms of inflammation and oxidative stress in these conditions. Its ability to modulate NF-κB signaling pathways positions OT-551 as a promising candidate for therapeutic development in ocular research. -
NF-κB Inhibitor
9,10-Dimethoxycanthin-6-one is an alkaloid compound that functions as an inhibitor of NF-κB. It demonstrates significant inhibitory activity with an IC50 value of 19.5 μM. This compound is primarily utilized in research pertaining to inflammatory responses and cancer pathways, making it relevant for studies investigating NF-κB signaling modulation. -
Anti-Inflammatory Agent
Catalpalactone is an anti-inflammatory agent that functions by inhibiting LPS-induced nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) in RAW264.7 macrophage cells. Additionally, it suppresses the activation of key signaling pathways, including IRF3, NF-κB, and IFN-β/STAT-1. Furthermore, Catalpalactone demonstrates the ability to reduce dopamine biosynthesis through the inhibition of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities, making it valuable for investigations into inflammatory processes and neurochemical pathways. -
Triterpenoid Saponin
Elatoside F is a triterpenoid saponin that exhibits significant anti-inflammatory activity. It effectively inhibits lipopolysaccharide-induced production of nitric oxide and the activation of the nuclear factor NF-κB. Elatoside F can be isolated in a single step from the plant Aralia elata, making it a valuable compound for research into inflammation and related pathways. -
NF-κB Inhibitor
Teuclatriol is an NF-κB inhibitor derived from Salvia mirzayanii, exhibiting notable anti-inflammatory properties. It effectively inhibits TNF-α secretion in a dose-dependent manner, making it valuable for research involving inflammatory pathways and the modulation of NF-κB activity. This compound is essential for studies focused on chronic inflammation, autoimmune diseases, and related therapeutic developments. -
NF-κB Inhibitor
NF-κB-IN-13 is a selective inhibitor of the NF-κB signaling pathway. This compound effectively suppresses lipopolysaccharide (LPS)-induced NF-κB activation and nitric oxide (NO) production in RAW264.7 macrophages, demonstrating its potential anti-inflammatory properties. NF-κB-IN-13 is valuable for research applications focusing on inflammation, immune response modulation, and potential therapeutic strategies for related diseases. -
NF-κB Inhibitor
APC0576 is an NF-κB inhibitor that effectively disrupts the activation of the NF-κB signaling pathway, demonstrating an IC50 of 1.0 μM for β-galactosidase. This compound significantly inhibits the release of IL-1-induced chemokines, making it a valuable tool for research related to diseases involving pathological endothelial cell activation. Its targeted action allows for the exploration of therapeutic strategies aimed at modulating inflammatory responses. -
NF-κB Inhibitor
CAY10657 is a potent NF-κB inhibitor that effectively downregulates the expression of proinflammatory cytokines, including IL-6, and chemokines such as MCP-1. This compound demonstrates significant anti-inflammatory activity, particularly in the context of meningitis induced by Streptococcus suis. CAY10657 is a valuable tool for researchers investigating inflammation and associated signaling pathways. -
NF-κB Inhibitor
Icariside F2 is a selective NF-κB inhibitor with an IC50 value of 16.25 μM. This aromatic glycoside, extracted from the leaves of E. ulmoides Oliver, exhibits significant anti-inflammatory activity. It is utilized in biomedical research to explore therapeutic strategies for conditions mediated by NF-κB signaling. -
Stable Isotope
TML-6-d3 is a deuterated derivative of the curcumin compound TML-6, demonstrating stability as a labeled isotope. This reagent primarily inhibits the synthesis of β-amyloid precursor protein and β-amyloid (Aβ), contributing to research in neurodegenerative diseases. TML-6-d3 upregulates ApoE, suppresses NF-κB and mTOR signaling pathways, and enhances activities related to neuroprotection. It serves as a valuable tool for studying the molecular mechanisms of Alzheimer's disease and related disorders. -
ROR-γ Inhibitor
CID 7309015 is a selective inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). This compound demonstrates significant potential in modulating inflammatory pathways, particularly in the context of NF-κB signaling and inflammatory arthritis research. CID 7309015 serves as a valuable tool for investigating the roles of ROR-γ in immune response and inflammatory diseases. -
11β-hydroxysteroid dehydrogenase 1 Inhibitor
Lunularin is a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1, exhibiting an IC50 of 45.44 μM for human and 17.39 μM for rat enzymes. This compound has been shown to modulate gene expression by upregulating Sirt1 and Hmox1 in liver tissue, while also reducing food intake, body weight gain, and blood glucose levels in high-fat diet mice. Furthermore, Lunularin displays anti-cancer properties by inhibiting cell proliferation and colony formation in renal and colon cancer cell lines, along with suppression of LPS-induced NF-κB pathway activation. This reagent is valuable for research in obesity, cancer biology, inflammation, and metabolic disorders. -
ACAT Inhibitor
ACAT-IN-8 is a selective inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT), a key enzyme involved in intracellular cholesterol esterification. By inhibiting ACAT, this compound modulates lipid metabolism and significantly impacts NF-κB mediated transcription. ACAT-IN-8 is useful for research applications related to cardiovascular diseases, metabolic disorders, and inflammation, providing insights into cholesterol-related pathways and their regulation. -
Sigma-2 ligand/Agonist
SW43 is a selective Sigma-2 ligand and agonist that plays a pivotal role in cancer research. This compound enhances the development of targeted therapeutic agents, showing significant antitumor activity when conjugated with DOX-L-NETA (89Y) in a VX2 liver tumor allograft rabbit model. Additionally, when combined with SW IV-52s to create SW III-123, SW43 activates the NF-κB pathway, demonstrating potent cytotoxic effects against ovarian cancer cell lines and promoting apoptosis. This dual functionality underscores its utility in cancer therapeutic development. -
IKKα Inhibitor
BAY32-5915 is a selective inhibitor of IKKα, exhibiting an IC50 value of 60 nM. This compound effectively prevents the activation of NF-κB without interfering with Doxorubicin-induced pathways. It is valuable for research in inflammation and cancer, providing insights into NF-κB signaling modulation. -
IKK/NF-κB Inhibitor
NF-κB-IN-1 is a selective inhibitor of the IκB kinase (IKK) and functions primarily through the inhibition of NF-κB signaling. This compound effectively blocks the activation of NF-κB, demonstrating potent anti-cancer activity by reducing cell viability in lung cancer cells. Additionally, NF-κB-IN-1 significantly diminishes the clonogenic potential of A549 cells, making it a valuable tool for research on cancer therapeutics targeting NF-κB pathways. -
Negative control of IKK
6-Chloro-7-deazaguanine serves as a negative control for IκB kinase (IKK), specifically lacking the essential 5-cyano group that defines its activity. As an inactive analog, it provides a useful reference for studying the IKKβ and IKKα pathways, which are crucial components of the canonical and non-canonical NF-κB signaling pathways. Researchers can utilize this compound to delineate the role of IKK in various cellular processes and disease models, particularly in inflammation and immune responses. -
IKK Inhibitor
SU1261 is a potent inhibitor of IKK, displaying Ki values of 10 nM for IKKα and 680 nM for IKKβ. This compound effectively inhibits non-canonical NF-κB signaling pathways, making it a valuable tool for studying the role of IKK in various cellular processes. Its application in research, particularly in osteosarcoma cell models such as U2OS, can provide insights into inflammatory responses and oncogenic signaling mechanisms. -
IKK/NF-κB Inhibitor
SR12343 is an IKK/NF-κB inhibitor that acts as a mimetic of the NF-κB essential modulator (NEMO)-binding domain. It effectively disrupts the interaction between IKKβ and NEMO, leading to inhibition of TNF-α- and LPS-induced NF-κB activation, with an IC50 of 37.02 μM for TNF-α-mediated pathways. SR12343 has been shown to reduce LPS-induced acute pulmonary inflammation in murine models, making it valuable for research into inflammatory and degenerative diseases. -
IKKβ Inhibitor
BOT-64 is a selective IκB kinase β (IKKβ) inhibitor with an IC50 value of 1 µM. This compound effectively inhibits lipopolysaccharide-induced activation of nuclear factor-κB (NF-κB) and the subsequent transcription of NF-κB-regulated inflammatory genes. BOT-64 is valuable for research into inflammatory pathways and NF-κB signaling, providing insights into potential therapeutic strategies for inflammatory diseases. -
ikkβ Inhibitor
IKKβ-IN-4 is a selective inhibitor of IkappaB kinase-β (IKKβ), with an IC50 value of 1.9 μM. IKKβ plays a crucial role in the NF-κB signaling pathway, which is implicated in various diseases, including inflammation and cancer. This compound is utilized in research to study the modulation of NF-κB activity and its potential therapeutic applications in related disease models. -
IKK2 Inhibitor
IKK2-IN-3 is a selective inhibitor of IKK2, demonstrating a potent inhibitory effect with an IC50 value of 0.075 μM. This compound effectively disrupts the NF-κB signaling pathway, impacting various cellular processes such as inflammation and immune response. IKK2-IN-3 is suitable for research applications involving the modulation of IKK2 activity in disease models and studying the role of NF-κB in cellular signaling. -
IKK2 Inhibitor
LY2409881 is a selective inhibitor of IκB kinase β (IKK2), demonstrating potent inhibition with an IC50 of 30 nM. This compound is primarily used in research for its ability to modulate the NF-κB signaling pathway, making it relevant for studying inflammation, cancer, and autoimmune diseases. Researchers utilize LY2409881 to explore its therapeutic potential in various disease models and to investigate the role of IKK2 in cellular processes.
