Nimesulide-d5 is a deuterated form of Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor. It demonstrates a time-dependent inhibitory effect on COX-2 with IC50 values ranging from 70 nM to 70 μM, while exhibiting negligible activity on COX-1 (IC50 >100 μM). Nimesulide-d5 is utilized in research applications focusing on inflammatory processes, pain management, and antipyretic effects, supporting studies aimed at understanding COX-2 mediated pathways.
Nimesulide-d5 is a deuterated form of Nimesulide, a selective cyclooxygenase-2 (COX-2) inhibitor. It demonstrates a time-dependent inhibitory effect on COX-2 with IC50 values ranging from 70 nM to 70 μM, while exhibiting negligible activity on COX-1 (IC50 >100 μM). Nimesulide-d5 is utilized in research applications focusing on inflammatory processes, pain management, and antipyretic effects, supporting studies aimed at understanding COX-2 mediated pathways.
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