NU6027

Catalog No.: A14136

ATR/CDK inhibitor

NU6027

NU6027 Chemical Structure

CAS NO. 220036-08-8

NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$200.00
50 mg
$300.00
10mM * 1mL in DMSO
$82.00
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Biological Activity

NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner.
Targets
ATR CDK2 DNA-PK CDK1
0.4 μM(Ki)1.3 μM(Ki)2.2 μM(Ki)2.5 μM(Ki)
In vitro DMSO 47 mg/mL (187.04 mM)
Water Insoluble
Ethanol 3 mg/mL (11.93 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 39.8 mL 198.98 mL 397.96 mL
0.5 mM 7.96 mL 39.8 mL 79.59 mL
1 mM 3.98 mL 19.9 mL 39.8 mL
5 mM 0.8 mL 3.98 mL 7.96 mL

*The above data is based on the productmolecular weight 251.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14136
Actions Inhibitor
CAS No. 220036-08-8
Formula C11H17N5O2
M. Wt 251.28
Solubility DMSO
Purity >98%
Synonyms NU-6027, NU 6027
SMILES C1CCC(CC1)COC2=NC(=NC(=C2N=O)N)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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