Catalog No.
Product Name
Application
Product Information
Citations
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p18INK inhibitor
NSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). - Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.
- Dextromethorphan (Discontinued) (DXM or DM) is an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties.
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inhibitor for GA perception
TSPC is an inhibitor for GA perception by in vitro and in planta evaluations. -
autoinducer of P. fischeri luciferase
N-(beta-ketocaproyl)-L-Homoserine lactone (N-(Ketocaproyl)-L-homoserine lactone, N-(β-Ketocaproyl)-L-hoMoserine lactone) is an autoinducer of P. fischeri luciferase and a component of quorum regulatory sensing. -
chemical UV filter
Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage. -
Eph family tyrosine kinase inhibitor
Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor. -
S-adenosylhomocysteine hydrolase inhibitor
3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 ?M; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity. -
antiproliferative agent
Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line. -
inhibitor of glycogen synthase kinase 3
5-bromoindole is an important pharmaceutical chemical intermediate and a potential inhibitor of glycogen synthase kinase 3 (GSK-3). -
non-steroidal anti-inflammatory drug
Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies. - AH10639 is a novel inhibitor of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.
- NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.
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hypoglycemic agent
Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity. -
active oxygen formation inducer
Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes. -
transcriptional inhibitor of G0/G1 switch 2
NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 hydrochloride can be used for chronic kidney disease. -
anticonvulsant/antiepileptic agent
Lvguidingan (Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide) is an anticonvulsant/antiepileptic agent. Lvguidingan (Anticonvulsant 7903) is found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain. - Tri-Salicylic Acid (Trisalicylic Acid), a product of the thermal decomposition of aspirin, is a biochemical for proteomics research.
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Biochemical Assay Reagent
DCIP sodium is a redox indicator utilized primarily in biochemical assays. Its distinctive blue coloration shifts according to the oxidation state of the analyte, making it effective in measuring enzymatic activities, including succinate dehydrogenase. Additionally, it serves as a valuable reagent in protein quantification methods, such as the Lowry assay, facilitating accurate analytical results in various research applications. -
Biochemical Assay Reagent
Bathocuproine disulfonate disodium (BCS) is a highly sensitive colorimetric reagent utilized for the detection of copper ions in biochemical assays. This compound exhibits a bright yellow color and possesses strong absorbance at specific wavelengths, enabling the quantification of trace levels of copper. BCS is instrumental in studying copper's biological roles, as well as in environmental monitoring and water quality testing, where its sensitivity allows for the identification of copper pollution, even at minimal concentrations. Accurate measurement of copper is essential for understanding its physiological effects and ecological impacts. -
Cholesterol-removing Agent
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation. -
Globular Protein
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications. -
Skin Depigmenting Agent
Monobenzone is a potent skin depigmenting agent that primarily targets the enzyme ribonucleotide reductase (RNR) by inhibiting its regulatory subunit, RRM2. It effectively induces depigmentation, making it a valuable compound in vitiligo research. Additionally, Monobenzone demonstrates significant anti-leukemic properties, inhibiting the proliferation and DNA synthesis of acute myeloid leukemia (AML) cells, and promoting cell cycle arrest and apoptosis. These dual functionalities position Monobenzone as a critical reagent in both dermatological and oncology studies. -
Excipient
SBE-β-CD is a sulfobutylether derivative of β-cyclodextrin primarily utilized as an excipient in pharmaceutical formulations. It enhances the solubility of poorly soluble compounds, thereby improving their bioavailability. SBE-β-CD is valuable in drug development, particularly for improving the delivery of hydrophobic agents in various therapeutic applications. -
Biochemical Assay Reagent
(±)-myo-Inositol-1-phosphate is a biochemical assay reagent known for its role as a phosphoinositide signaling molecule. This compound is involved in cellular processes such as insulin signaling, cell proliferation, and regulation of ion channels. It is utilized in various research applications, including studies on diabetes, neurodegenerative diseases, and cell signaling pathways. -
Iron Colorimetric Reagent
Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent primarily used for the detection of iron, exhibiting an optimal absorbance at 535 nm for iron complexes. This reagent facilitates the determination of iron concentrations in aqueous solutions without the necessity for extraction solvents. Additionally, BPS is utilized as a precursor in the synthesis of specialized complexes, including Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) and ruthenium(II) tris(bathophenanthrolinedisulfonate), and plays a role in catalyst systems for the oxidation of 2-hexanol by forming stable water-soluble complexes with palladium. -
Colorimetric Reagent
2-Thiobarbituric acid is a colorimetric reagent primarily used for the quantitative detection of malondialdehyde (MDA), a key biomarker of lipid peroxidation. It forms a chromogenic complex with MDA that can be measured at 532 nm. This reagent is essential for studies investigating oxidative stress and lipid peroxidation in various biological samples. -
Biochemical Reagent
Copper sulfate pentahydrate is a biochemical reagent commonly used in cell culture applications. This compound demonstrates the ability to reduce the production of reactive oxygen species (ROS) and downregulate the expression of MyD88 and c-Rel genes. Additionally, copper sulfate pentahydrate affects enzymatic activities by decreasing T-superoxide dismutase (T-SOD), catalase (CAT), and glutathione (GSH) levels, while promoting the activities of caspase-3, -8, and -9. Its cytotoxic effects make it valuable for studies involving cellular apoptosis and oxidative stress. -
Biochemical Assay Reagent
Rhodamine B isothiocyanate (RBITC) is a reactive fluorescent dye widely used for covalent labeling of biomolecules in imaging and analytical applications. The isothiocyanate functional group readily reacts with primary amines on proteins, peptides, and other biomolecules to form stable thiourea linkages, enabling durable fluorescent tagging. RBITC emits bright orange-red fluorescence upon green light excitation, providing strong signal intensity and excellent photostability for visualization in complex biological systems. Owing to its high sensitivity, chemical stability, and compatibility with diverse assay conditions, RBITC is extensively utilized in cell biology, immunology, neurobiology, and fluorescence microscopy studies for tracking molecular localization and dynamics. -
Biochemical Reagent
Mutanolysin is a muralytic enzyme that acts as a bacteriolytic agent, targeting bacterial cell walls. It exhibits significant protective effects against hepatic injury and has been shown to decrease TNF-α production in isolated Kupffer cells stimulated with peptidoglycan-polysaccharide. Additionally, Mutanolysin mitigates the elevation of plasma anti-peptidoglycan antibodies and TNF-α levels in rat models, making it a valuable reagent for studying inflammation and bacterial infections. Its applications extend to biochemical research, particularly in exploring immune responses and hepatic health. -
Ester Product
Dodecane is an aliphatic hydrocarbon classified as an ester product. It has been demonstrated to induce elevated levels of TNF-α expression, a key cytokine involved in inflammatory responses, and can also lead to increased transepidermal water loss (TEWL), which is critical for studies on skin barrier function. This compound is relevant for research applications in inflammation, dermatological studies, and understanding skin permeability. -
Impurity
Gefitinib impurity 2 is an impurity of the EGFR tyrosine kinase inhibitor, Gefitinib. While Gefitinib exhibits potent and selective inhibition of EGFR with an IC50 of 33 nM, this impurity may be relevant for studies focused on the characterization and validation of Gefitinib-related compounds. Research applications primarily include analytical chemistry and quality control in the synthesis of Gefitinib. Additionally, the impurity may provide insights into the pharmacological behavior and metabolic pathway analysis of EGFR inhibitors. -
Biochemical Reagent
Zapotin is a polymethoxyflavone that functions as a biochemical reagent, exhibiting multiple biological activities. It demonstrates significant antidepressant, anticancer, antifungal, and antioxidant properties, making it a candidate for chemopreventive and chemotherapeutic applications. Studies show that Zapotin effectively reduces large aberrant crypt foci in CF-1 mouse models and inhibits autophagosome formation. Additionally, it displays inhibitory activity in mouse mammary organ culture, with an IC50 value of 50 µg/mL. -
Drug Intermediate
Camphorsulfonate sodium functions as an organic synthesis intermediate with significant utility in the development of derivatives exhibiting succinate dehydrogenase (SDH) inhibitory activity through scaffold hopping. Additionally, it serves as an organocatalyst, effectively modulating the porosity of graphene films as a pore-forming additive. This compound is valuable in research applications focused on binder-free porous graphene films and fungicide development. -
Biochemical Assay Reagent
Manganese chloride (tetrahydrate) is a biochemical assay reagent that plays a critical role in regulating enzyme activities, particularly histone acetyltransferase (HAT) and histone deacetylase (HDAC), influencing gene expression. This compound exhibits biological activities including neurotoxicity, embryotoxicity, and reproductive toxicity. It is predominantly utilized in research related to neurodegenerative diseases and toxicology, providing valuable insights into cellular and molecular mechanisms.
