Catalog No.
Product Name
Application
Product Information
Citations
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Cholesterol-removing Agent
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation. -
Globular Protein
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications. -
Skin Depigmenting Agent
Monobenzone is a potent skin depigmenting agent that primarily targets the enzyme ribonucleotide reductase (RNR) by inhibiting its regulatory subunit, RRM2. It effectively induces depigmentation, making it a valuable compound in vitiligo research. Additionally, Monobenzone demonstrates significant anti-leukemic properties, inhibiting the proliferation and DNA synthesis of acute myeloid leukemia (AML) cells, and promoting cell cycle arrest and apoptosis. These dual functionalities position Monobenzone as a critical reagent in both dermatological and oncology studies. -
Excipient
SBE-β-CD is a sulfobutylether derivative of β-cyclodextrin primarily utilized as an excipient in pharmaceutical formulations. It enhances the solubility of poorly soluble compounds, thereby improving their bioavailability. SBE-β-CD is valuable in drug development, particularly for improving the delivery of hydrophobic agents in various therapeutic applications. -
Biochemical Assay Reagent
(±)-myo-Inositol-1-phosphate is a biochemical assay reagent known for its role as a phosphoinositide signaling molecule. This compound is involved in cellular processes such as insulin signaling, cell proliferation, and regulation of ion channels. It is utilized in various research applications, including studies on diabetes, neurodegenerative diseases, and cell signaling pathways. -
Iron Colorimetric Reagent
Bathophenanthrolinedisulfonic acid disodium salt (BPS) is a colorimetric reagent primarily used for the detection of iron, exhibiting an optimal absorbance at 535 nm for iron complexes. This reagent facilitates the determination of iron concentrations in aqueous solutions without the necessity for extraction solvents. Additionally, BPS is utilized as a precursor in the synthesis of specialized complexes, including Europium(III) tris(dibenzoylmethanate) bis(bathophenanthrolinedisulfonate) and ruthenium(II) tris(bathophenanthrolinedisulfonate), and plays a role in catalyst systems for the oxidation of 2-hexanol by forming stable water-soluble complexes with palladium. -
Colorimetric Reagent
2-Thiobarbituric acid is a colorimetric reagent primarily used for the quantitative detection of malondialdehyde (MDA), a key biomarker of lipid peroxidation. It forms a chromogenic complex with MDA that can be measured at 532 nm. This reagent is essential for studies investigating oxidative stress and lipid peroxidation in various biological samples. -
Biochemical Reagent
Copper sulfate pentahydrate is a biochemical reagent commonly used in cell culture applications. This compound demonstrates the ability to reduce the production of reactive oxygen species (ROS) and downregulate the expression of MyD88 and c-Rel genes. Additionally, copper sulfate pentahydrate affects enzymatic activities by decreasing T-superoxide dismutase (T-SOD), catalase (CAT), and glutathione (GSH) levels, while promoting the activities of caspase-3, -8, and -9. Its cytotoxic effects make it valuable for studies involving cellular apoptosis and oxidative stress. -
Biochemical Assay Reagent
Rhodamine B isothiocyanate (RBITC) is a reactive fluorescent dye widely used for covalent labeling of biomolecules in imaging and analytical applications. The isothiocyanate functional group readily reacts with primary amines on proteins, peptides, and other biomolecules to form stable thiourea linkages, enabling durable fluorescent tagging. RBITC emits bright orange-red fluorescence upon green light excitation, providing strong signal intensity and excellent photostability for visualization in complex biological systems. Owing to its high sensitivity, chemical stability, and compatibility with diverse assay conditions, RBITC is extensively utilized in cell biology, immunology, neurobiology, and fluorescence microscopy studies for tracking molecular localization and dynamics. -
Biochemical Reagent
Mutanolysin is a muralytic enzyme that acts as a bacteriolytic agent, targeting bacterial cell walls. It exhibits significant protective effects against hepatic injury and has been shown to decrease TNF-α production in isolated Kupffer cells stimulated with peptidoglycan-polysaccharide. Additionally, Mutanolysin mitigates the elevation of plasma anti-peptidoglycan antibodies and TNF-α levels in rat models, making it a valuable reagent for studying inflammation and bacterial infections. Its applications extend to biochemical research, particularly in exploring immune responses and hepatic health. -
Ester Product
Dodecane is an aliphatic hydrocarbon classified as an ester product. It has been demonstrated to induce elevated levels of TNF-α expression, a key cytokine involved in inflammatory responses, and can also lead to increased transepidermal water loss (TEWL), which is critical for studies on skin barrier function. This compound is relevant for research applications in inflammation, dermatological studies, and understanding skin permeability. -
Impurity
Gefitinib impurity 2 is an impurity of the EGFR tyrosine kinase inhibitor, Gefitinib. While Gefitinib exhibits potent and selective inhibition of EGFR with an IC50 of 33 nM, this impurity may be relevant for studies focused on the characterization and validation of Gefitinib-related compounds. Research applications primarily include analytical chemistry and quality control in the synthesis of Gefitinib. Additionally, the impurity may provide insights into the pharmacological behavior and metabolic pathway analysis of EGFR inhibitors. -
Biochemical Reagent
Zapotin is a polymethoxyflavone that functions as a biochemical reagent, exhibiting multiple biological activities. It demonstrates significant antidepressant, anticancer, antifungal, and antioxidant properties, making it a candidate for chemopreventive and chemotherapeutic applications. Studies show that Zapotin effectively reduces large aberrant crypt foci in CF-1 mouse models and inhibits autophagosome formation. Additionally, it displays inhibitory activity in mouse mammary organ culture, with an IC50 value of 50 µg/mL. -
Drug Intermediate
Camphorsulfonate sodium functions as an organic synthesis intermediate with significant utility in the development of derivatives exhibiting succinate dehydrogenase (SDH) inhibitory activity through scaffold hopping. Additionally, it serves as an organocatalyst, effectively modulating the porosity of graphene films as a pore-forming additive. This compound is valuable in research applications focused on binder-free porous graphene films and fungicide development. -
Biochemical Reagent
Xanthomegnin is a yellow pigment with biochemical properties isolated from the fungus Trichophyton megnini. This compound is widely utilized in various research applications, particularly in the study of fungal metabolism and pigment biosynthesis. Its unique colorimetric characteristics make it a valuable reagent in biochemical assays and analytical studies involving enzymatic activity and compound interactions within biological systems. -
Biochemical Assay Reagent
Manganese chloride (tetrahydrate) is a biochemical assay reagent that plays a critical role in regulating enzyme activities, particularly histone acetyltransferase (HAT) and histone deacetylase (HDAC), influencing gene expression. This compound exhibits biological activities including neurotoxicity, embryotoxicity, and reproductive toxicity. It is predominantly utilized in research related to neurodegenerative diseases and toxicology, providing valuable insights into cellular and molecular mechanisms. -
Drug Intermediate
5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide serves as an essential drug intermediate in the synthesis of diverse bioactive molecules. This compound's structural framework enables exploration in medicinal chemistry and drug development, facilitating the creation of therapeutically relevant agents. Researchers utilize this intermediate to optimize pharmacological properties and enhance biological activity across various applications. -
Biochemical Reagent
1-Pyrenedecanoic acid is a biochemical reagent primarily utilized to assess membrane fluidity. This compound intercalates into lipid bilayers, enabling the study of membrane dynamics and properties. It is valuable in research focusing on cellular membrane behavior and related physiological processes. -
Drug Intermediate
CCT-010354 is a chemical intermediate utilized in the synthesis of PPARα/δ dual agonists. This compound plays a key role in the development of therapeutics targeting metabolic disorders and inflammatory diseases, where modulation of peroxisome proliferator-activated receptors (PPARs) is beneficial. Its application in drug development underscores its significance in pharmaceutical research. -
Biochemical Assay Reagents
1,1'-(Azodicarbonyl)-dipiperidine (ADDP) functions as a versatile reagent in biochemical assays, primarily utilized for the condensation reactions of alcohols with acidic compounds. This compound is instrumental in the synthesis of GPR120 agonists, which exhibit antidiabetic properties, as well as in the development of triple agonists targeting PPARα, PPARγ, and PPARδ. ADDP is particularly valuable for research in metabolic diseases, facilitating advancements in therapeutic discovery. -
Phosphoramidites
DMT-2'-F-6-chloro-dA phosphoramidite is a specialized phosphoramidite used for the synthesis of oligonucleotides. Its incorporation into oligonucleotide sequences allows for the introduction of fluorinated modifications, enhancing stability and specificity. This reagent is essential for chemical biology applications and the development of nucleic acid-based therapeutics. -
Drug Intermediate
2,4-Dihydroxybenzaldehyde serves as a drug intermediate with applications in the synthesis of various Schiff base compounds. This compound demonstrates notable anti-angiogenic, anti-inflammatory, and analgesic activities, attributed to its ability to inhibit the expression of iNOS and COX-2, thus reducing the production of nitric oxide and reactive oxygen species. It is widely utilized in research focused on inflammatory conditions, contributing to the understanding of mechanisms underlying these diseases. -
Drug Intermediate
Kanjone is a chemical intermediate derived from Millettia peguensis, primarily utilized in the synthesis of protein tyrosine phosphatase 1B (PTP1B) inhibitors. This compound exhibits potential therapeutic implications for the study of diabetes and neurological disorders, facilitating research into the modulation of PTP1B activity. Its application serves as a valuable tool in advancing understanding of metabolic regulation and neurodegenerative diseases. -
Drug Impurity
Ramipril diketopiperazine is a chemical impurity associated with the ACE inhibitor Ramipril. It is important for analytical studies and quality control in pharmaceutical research, particularly in the evaluation of drug formulation and stability. The presence of this impurity can influence the pharmacokinetics and safety profile of Ramipril, making it crucial for researchers analyzing drug metabolism and efficacy. -
Ramiprilat Impurity
Ramiprilat diketopiperazine, also known as Impurity K of Ramiprilat, serves as a significant impurity within the context of pharmaceutical research. Ramiprilat, an active metabolite of Ramipril, functions primarily as a potent angiotensin-converting enzyme (ACE) inhibitor. This compound is important for studying the effects and stability of Ramiprilat in various formulations and can be useful in analytical chemistry to ensure the purity of ACE inhibitors in development. -
Biochemical Assay Reagents
3-Azidopropanol is an azide-containing alcohol utilized as a substrate in click chemistry reactions. It facilitates Cu-catalyzed addition reactions with propargyl alcohol, making it a valuable tool in bioconjugation and labeling strategies. This reagent is essential for applications in biochemical assays, enabling the study of biomolecular interactions and the development of targeted therapeutics. -
MOF
Antibacterial agent 18 is a multi-arm aggregation-induced emission (AIE) molecule targeting bacterial cell walls. This compound exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria by disrupting the synthesis of critical cell wall components, effectively inhibiting bacterial growth or inducing cell death. It is suitable for research applications focused on understanding bacterial resistance mechanisms and developing novel antibacterial therapies. -
Biochemical Reagent
Methyl 2-amino-5-bromobenzoate is a biochemical reagent that serves as a precursor for synthesizing 2-benzamidobenzoic acid, a recognized FabH inhibitor. Additionally, its derivatives have demonstrated the ability to inhibit PqsD, which is part of the quorum sensing (QS) system in Pseudomonas aeruginosa. This compound is valuable for research involving antibiotic development and investigation of bacterial communication pathways. -
Biochemical Reagent
Silver(I) sulfide is a biochemical reagent with prominent antibacterial properties. It exhibits effective antimicrobial activity against a range of resistant bacteria, including both Gram-positive and Gram-negative strains. This compound is valuable for research into bacterial infections, particularly those caused by pathogens such as *Staphylococcus aureus*, *Streptococcus agalactiae*, *Escherichia coli*, and *Pseudomonas* species. -
Biochemical Assay Reagent Control
Calcium hydroxide, a dihydroxy form of calcium, serves as an important biochemical assay reagent control. This compound is utilized for its buffering capacity and as a pH modifier in various biological experiments. Calcium hydroxide is critical for maintaining optimal conditions in enzymatic assays and other biochemical applications, contributing to accurate and reproducible results in research settings. -
Biochemical Assay Reagent
Lactobionic acid calcium dihydrate is a biomimetic acid that primarily acts as a biochemical assay reagent. This compound exhibits antioxidant and antimicrobial properties, making it useful in various research applications, including food safety and functional product development. Additionally, it has demonstrated the ability to inhibit DNA repair and protein synthesis, as well as induce oxidative stress and block specific metabolic pathways against methicillin-resistant Staphylococcus aureus (MRSA). Lactobionic acid calcium dihydrate can be sourced through electrolytic methods, microbial fermentation, or biocatalytic approaches. -
Biochemical Assay Reagent
Cephalin from bovine brain is a phospholipid that serves as a key biochemical assay reagent. It plays a crucial role in the formation of autophagosome membranes by acting as a lipid anchor for the autophagy-related protein Atg8/LC3. This compound enhances autophagic flux, facilitates cell differentiation, regulates lipid droplet fusion, and influences lipid metabolism, contributing to membrane integrity and potential anti-aging effects. Its applications in research include studies on autophagy, lipid metabolism, and cellular differentiation. -
Phosphoramidite Monomer
2'-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer targeting oligonucleotide synthesis. This reagent is instrumental in the production of RNA oligonucleotides, offering enhanced stability and improved biochemical properties. Its applications include the development of antiviral agents and therapeutics through the manipulation of RNA structures. -
dIPhosphoramidite
DMT-dA(PAc) Phosphoramidite is a dIPhosphoramidite that serves as an essential building block for the synthesis of DNA and RNA oligonucleotides. This reagent is specifically designed to facilitate the incorporation of deoxyadenosine into nucleic acid sequences, providing researchers with the ability to produce modified oligonucleotides for various applications, including genetic engineering, antisense therapy, and molecular diagnostics. Its protective groups ensure stable synthesis while maintaining high efficiency in coupling reactions. -
Phosphoramidite Monomer
S-cEt-U phosphoramidite is a modified phosphoramidite monomer designed for use in oligonucleotide synthesis. This reagent facilitates the incorporation of modified nucleotides into DNA or RNA sequences, expanding the versatility of synthetic oligonucleotides. Its application is critical in various fields, including gene therapy, antisense oligonucleotide development, and the creation of innovative bioconjugates. -
Phosphoramidites
DMT-2'-F-dA(bz) phosphoramidite is a phosphoramidite specifically designed for the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-fluoro-deoxyadenosine residues into nucleic acid sequences, enhancing the stability and biological activity of the resulting oligonucleotides. Its applications are significant in fields such as gene therapy, antisense oligonucleotide research, and RNA interference studies. -
Phosphoramidites
DMT-2'O-Methyl-rC(tac) Phosphoramidite is a specialized phosphoramidite utilized in the synthesis of oligonucleotides. This compound facilitates the incorporation of 2'-O-methyl modified ribonucleosides, enhancing the stability and binding affinity of RNA sequences. Its applications are significant in molecular biology for constructing RNA oligonucleotides with improved properties for research and therapeutic purposes. -
Biochemical Reagent
Cytarabine-daunorubicin, also known as CPX-351, is a liposomal formulation that synergistically combines cytarabine and daunorubicin in a 5:1 ratio. This targeted delivery system enhances the concentration of both compounds in leukemia cells while minimizing exposure to normal bone marrow cells. It is utilized in research focused on leukemia treatment and mechanisms, making it a valuable tool for investigating therapeutic strategies and drug efficacy in hematological malignancies. -
Phosphoramidite Monomer
DMT-dI Phosphoramidite is a modified phosphoramidite monomer that serves as a key building block in oligonucleotide synthesis. This compound facilitates the efficient incorporation of deoxyinosine into nucleic acid strands, enhancing the diversity of synthetic oligonucleotides. Its application is essential for various research areas, including gene synthesis, RNA interference studies, and the development of diagnostic tools. -
Cytosine Phosphoramidite
Ac-rC Phosphoramidite is a cytosine phosphoramidite utilized in the chemical synthesis of RNA oligonucleotides. It facilitates the incorporation of cytidine nucleotides into synthetic RNA strands while maintaining the structural integrity of the molecule during complex synthetic procedures through its specialized protecting groups. This reagent is essential for advances in RNA-based research and applications in genetic engineering and antiviral studies. -
Phosphoramidite Monomer
Fmoc-protected DMT-Dt PEG2 NH2 amidite is a phosphoramidite monomer designed for oligonucleotide synthesis. This compound features a protective Fmoc group and a PEG2 linker, enhancing solubility and facilitating the incorporation of amine functionalities into nucleic acids. It is ideal for applications in DNA and RNA synthesis, enabling the development of complex oligonucleotide structures for research in genomics and therapeutic applications. -
Phosphoramidites
DMT-2'-OMe-dA(bz) phosphoramidite is a versatile phosphoramidite used primarily for the synthesis of oligonucleotides. This modified nucleoside contributes to enhanced stability and solubility in synthetic applications. It is suitable for various research applications, including molecular biology, gene synthesis, and diagnostic development. -
Phosphoramidites
N4-Benzoyl-5’-O-(4,4’-dimethoxytrityl)-3’-deoxy-3’-fluoro-beta-D-xylofuranosyl cytidine-2’-CED-phosphoramidite is a phosphoramidite utilized in the synthesis of oligonucleotides. Its structural properties enhance the incorporation of modified nucleotides, contributing to the development of oligonucleotides with improved stability and biological activity. This reagent is valuable for applications in gene modulation, nucleic acid research, and the exploration of antisense and RNA interference strategies. -
Phosphoramidites
DMT-2'-F-dA Phosphoramidite is a modified phosphoramidite that serves as a key reagent in the synthesis of oligonucleotides. Its unique structure incorporates a fluorine atom at the 2' position, enabling enhanced stability and functionality of nucleic acids. This compound is essential for researchers in the fields of molecular biology and genetic engineering, facilitating the development of tailored oligonucleotide sequences for various applications, including diagnostics and therapeutics. -
Phosphoramidites
DMT-LNA-5mA phosphoramidite is a versatile phosphoramidite used primarily for the synthesis of oligonucleotides. Its unique structure features an LNA (locked nucleic acid) modification, enhancing the binding affinity and specificity of oligonucleotide probes. This reagent is essential for applications in molecular biology, including gene expression analysis, antisense oligonucleotide development, and RNA interference studies. -
Phosphoramidites
DMT-LNA-G phosphoramidite is a phosphoramidite that facilitates the synthesis of locked nucleic acid (LNA) containing oligonucleotides. Its unique chemical structure enhances binding affinity and stability of nucleic acid probes, improving their performance in various applications such as molecular diagnostics, RNA interference, and antisense therapy. This reagent is essential for researchers focused on the development of innovative nucleic acid-based therapeutics and tools. -
Phosphoramidites
DMT-2'-O-TBDMS-G(dmf)-CE-phosphoramidite is a phosphoramidite utilized in the synthesis of oligonucleotides. This compound serves as a key building block, facilitating the incorporation of modified nucleotides during solid-phase synthesis. Its biological activity supports research applications in gene synthesis, antisense oligonucleotide development, and RNA interference studies. As a versatile reagent, it enables advancements in nucleic acid research and therapeutic applications. -
Phosphoramidites
DMT-2'-F-Cytidine Phosphoramidite is a specialized phosphoramidite compound used in the synthesis of oligonucleotides. This reagent facilitates the introduction of a 2'-fluorine modification, enhancing the stability and affinity of oligonucleotide therapeutics. Its application is crucial in studying nucleic acid interactions and developing novel antisense and RNAi strategies. -
Linker-drug Intermediate
MC-Gly-Gly-Phe-Gly-NH-CH2-O-amide-Eribulin functions as a linker-drug intermediate in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents with monoclonal antibodies, enhancing targeted delivery to cancer cells. Its application is crucial for research in developing novel ADCs to improve the efficacy and safety of cancer treatments. -
Drug Intermediate
ProX1-(SS)-DOTAGA_R is a drug intermediate designed for targeted radionuclide delivery. It specifically facilitates the localization of therapeutic agents to diseases characterized by ACP3 expression. This compound is instrumental in advancing radiopharmaceutical research and developing precision medicine strategies.
