Others

Lodenosine is a failed experimental agent for the treatment of HIV

Trimipramine (Surmontil, Rhotrimine, Stangyl) is a tricyclic antidepressant (TCA). It has antidepressant, anxiolytic, antipsychotic, sedative, and analgesic effects

Nimorazole is a nitroimidazole anti-infective. It is also being investigated for the treatment of head and neck cancer.

Panipenem is a carbapenem antibiotic used in combination with betamipron

Ioversol is low osmolality, nonionic, radiographic contrast agent.

Triphendiol (NV-196) is a synthetic isoflavene. Triphendiol (NV-196) is another investigational drug in the Marshall Edwards, Inc., oncology drug pipeline. Triphendiol is broadly cytostatic and cytotoxic against most forms of human cancer cells in vitro, and has been shown to cause cell cycle arrest (or stop cells increasing in number) and to induce apoptosis (or initiate programmed cell death) in various cancer cell lines.

ME-143 is a derivative of triphendiol and is a highly potent, pan acting anti-cancer.

Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity.

SNT-207707 is an oral MC4-Receptor Antagonist

Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate with the antitumor activity.

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431.

TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane.

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

Pirodavir was one of the most promising capsid-binding compounds to show efficacy in human clinical trials for chemoprophylaxis of the common cold.

Eslicarbazepine acetate is an antiepileptic drug.

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ?300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM).

TP808 is a useful intermediate for the synthesis of diverse tetracycline antibiotics.

NVP-231 is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK.

Quinacrine 2HCl is a histamine N-methyltransferase inhibitor

Apramycin Sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius

MGL-3196 is an orally small-molecule liver-directed thyroid hormone receptor agonist designed to increase cholesterol uptake into the liver and increase its metabolism.

NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC50 value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer.

Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

Pyrroloquinoline quinone is a cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins.

TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13??3 nM.

Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol.

SP-420 is an orally active small molecule that selectively binds iron and removes it from the body. In animal studies, SP-420 has shown excellent tissue penetration, highly efficient iron binding and a promising safety profile.

Deferitrin (GT-56-252) is the first drug in a class of desferrithiocin-derived hexadentate iron chelators.

Gastrofensin AN 5 free base, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.

RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein.

BAY 57-1293 is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex.

Laxogenin is a new steroidal sapogenin isolated from Smilax sieboldi Miq.

Enecadin is a neuroprotective agent extracted from patent US 8623823 B2.

Oleanolic acid hemiphthalate disodium salt is an anti-inflammatory agent.

Harmane (harman) is a heterocyclic amine found in a variety of foods including coffee, sauces, and cooked meat. It is also present in tobacco smoke.

5-BrdU is a synthetic thymidine analog; incorporated into DNA during replication. Used in assays for cell proliferation.

Bupranolol is a non-selective beta blocker without intrinsic sympathomimetic activity (ISA), but with strong membrane stabilizing activity.

Nisoxetine hydrochloride is a selective and potent inhibitor of norepinephrine transporter with little or no affinity for a range of other neurotransmitter receptors. Nisoxetine hydrochloride is an inhibitor of SLC6A2.

Ruzadolane (UP 26-91) is a non-narcotic, centrally-acting analgesic agent.

N/A

L161240, was active against a P. aeruginosa construct in which the endogenous lpxC gene was inactivated and in which LpxC activity was supplied by the lpxC gene from E. coli.

Shows antimalerial activity with IC50 values of 11.2 nM for 3D7 strain, 12.6 nM for HB3 strain, 17.6 nM for K1 strain

Golotimod is an orally bioavailable synthetic peptide containing the amino acids D-glutamine and L-tryptophan connected by a gamma-glutamyl linkage with potential immunostimulating, antimicrobial and antineoplastic activities.

3,4-Dehydro Cilostazol is a metabolite of Cilostazol.

4'-trans-Hydroxy Cilostazol is a metabolite of Cilostazol.

NAV-2729 is a dual Arf1/Arf6 activation inhibitor.

NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM.

BMS-747158-02 is a fluorine 18?Clabeled pyridaben derivative designed as a new myocardial perfusion imaging agent for use with positron emission tomography (PET).

N-Methyl Metribuzin is an aminotriazinone and the methylamine analogue of the herbicide Metribuzin.

Metazathioprine is a methylated derivative of azathioprine (AZA). It demonstrated the greatest values of apparent and specific partition coefficients in n-octanol/phosphate buffer at pH 5.7 and pH 7.4 among purine derivatives such as 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and AZA.