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Catalog No.
Product Name
Application
Product Information
Citations
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hepcidin production inhibitor
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM. -
rat adenylate kinase II inhibitor
N6-Methyladenosine 5'-monophosphate disodium salt is an activator of glycogen phosphorylase b, with a Ka value of 22 ?M. N6-Methyladenosine 5'-monophosphate disodium salt is a non-competitive rat adenylate kinase II inhibitor. -
SE inhibitor
NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. -
Cell adhesion inhibitor
K-7174 dihydrochloride is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1beta or TNF-alpha. -
DNA repair inhibitor
KRX-0402 is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin?€?s lymphoma. -
Hyaluronan (HA) synthesis inhibitor
4-Methylumbelliferone is a selective inhibitor of Hyaluronan (HA) synthesis which is thought to function as an inhibitor via the depletion of UDP-glucuronic acid, the common substrate for HA synthesis. -
Hydrogen peroxide inhibitor
Acetanilide is used as an inhibitor in hydrogen peroxide and is used to stabilize cellulose ester varnishes. -
DprE1 inhibitor
BTZ043 (BTZ038, BTZ044) inhibits decaprenylphosphoryl-β-d-ribose 2?-epimerase, which is an enzyme which produces the cell wall of the pathogenic bacterium Mycobacterium tuberculosis. -
Monoamine reuptake inhibitor
Diclofensine (Ro 8-4650) acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and noradrenaline. -
dipeptidase inhibitor
Cilastatin is a dipeptidase inhibitor that specifically inhibits DPEP1 (dehydrodipeptidase I), a renal membrane-bound glycoprotein involved in the hydrolytic metabolism of penem and carbapenem ??-lactam antibiotics. -
HPPD inhibitor
Nitrisinone is a competitive inhibitor that reversibly inhibits 4-Hydroxyphenylpyruvate oxidase (dioxygenase). -
Cytochrome P450 Inhibitor
Verapamil EP Impurity C hydrochloride is a known impurity of Verapamil, primarily acting as a Cytochrome P450 inhibitor. This compound exhibits significant biological activity as a calcium channel blocker, contributing to its role as a first-generation P-glycoprotein (P-gp) inhibitor. Its utility in research includes studies on drug metabolism, pharmacokinetics, and interactions with P-gp transporters, making it a valuable reagent for pharmacological investigations. -
Growth Hormone Releasing Inhibitor
Boc-D-Trp(For)-OH is a synthetic compound designed to inhibit the Growth Hormone Releasing Inhibitor (GHRH). This derivative of tryptophan exhibits significant pharmacological activities, including the inhibition of growth hormone release, promotion of sleep induction, and anti-inflammatory effects. It serves as a valuable tool in research applications aimed at studying hormone regulation and neurobiology. -
PWD Inhibitor
Cyclo(IP) (Cyclo-(L-Pro-L-Ile)) is a diketopiperazine that functions as a phytopathogen wilt disease (PWD) inhibitor. It effectively suppresses the severity of PWD and enhances the expression of defense-related genes, emulating the effects of treatment with Bacillus thuringiensis JCK-1233. This compound is valuable in research focused on plant disease management and the exploration of plant defense mechanisms. -
TAFI Inhibitor
IQB-782 is a selective inhibitor of the thrombin activatable fibrinolysis inhibitor (TAFI), exhibiting an apparent inhibition constant (Ki(app)) of 0.14 μM. This compound demonstrates significant mucolytic-expectorant activity, making it valuable in research related to fibrinolytic processes and respiratory conditions. Its ability to modulate TAFI activity positions IQB-782 as a promising tool for studying thrombotic and inflammatory diseases. -
Protein Synthesis Inhibitor
O-Propargyl-Puromycin is an alkyne analog of puromycin that serves as a potent inhibitor of protein synthesis. This compound features an alkyne group that facilitates its function as a click chemistry reagent, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. O-Propargyl-Puromycin is valuable in various biological research applications, enabling studies related to protein synthesis pathways and the development of bioorthogonal labeling techniques. -
GAPDH Inhibitor
Sodium iodoacetate is a specific inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), effectively disrupting glycolytic pathways. This compound is utilized in research to study the mechanisms of glucose metabolism and its implications in various diseases. Additionally, sodium iodoacetate has been employed to induce osteoarthritis and associated pain models in experimental animal studies, providing valuable insights into joint pathophysiology. -
Trypsin Inhibitor
Fetuin, Fetal Bovine Serum is a 64 kDa plasma glycoprotein secreted by the liver, known for its ability to inhibit trypsin activity. This reagent enhances cellular attachment, growth, and differentiation, making it a valuable tool for cell culture applications. Its role as a trypsin inhibitor supports various experimental designs in biological research, particularly in studies involving cell signaling and development. -
Corrosion Inhibitor
4-Aminobenzaldehyde is an effective corrosion inhibitor targeting metal surfaces to prevent oxidative degradation. This compound serves as a valuable synthetic reagent and monomer in the production of monoazo dyes and photocurable ion exchange resins. Its unique properties make it suitable for diverse applications in materials science and chemical research, particularly in areas related to corrosion prevention and polymer synthesis. -
SB9 Inhibitor
Serpin B9-IN-1 (BTCA) is a selective inhibitor targeting Serpin B9 (SB9), a natural inhibitor of granzyme B (GrB) that is implicated in promoting lung cancer cell metastasis to the bone marrow. Elevated levels of SB9 in cancer cells enhance their proliferation and metastatic potential through interaction with GrB in an immune cell-dependent manner. Inhibition of SB9 by Serpin B9-IN-1 has been shown to significantly impair immunotherapy responses for lung cancer with bone metastases in the caudal artery (CA) mouse model, making it a valuable reagent for cancer research focused on the tumor microenvironment and immune evasion. -
Rnase Inhibitor
Diethyl pyrocarbonate is a potent, non-specific chemical inhibitor of RNases, primarily targeting histidine residues by binding to imidazole groups. This reagent exhibits significant biological activity in vitro, modifying serine, threonine, histidine, and tyrosine residues, which provides valuable tools for studying protein interactions and enzymatic mechanisms. Additionally, diethyl pyrocarbonate has been utilized in research to explore central chemosensitivity and can serve as a useful model compound in various biochemical studies. -
CSE Inhibitor
Cystathionine-γ-lyase-IN-1 is a selective inhibitor of cystathionine γ-lyase (CSE), demonstrating an IC50 value of 6.3 μM. This compound serves as a valuable tool in studying the role of CSE in various biological processes, including metabolism and pathophysiology. Additionally, Cystathionine-γ-lyase-IN-1 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it useful in click chemistry applications for further research. -
Glutathionase Inhibitor
S-(p-Nitrobenzyl)glutathione is a competitive inhibitor of glutathionase, targeting the enzymatic breakdown of glutathione. Upon metabolic conversion by rat kidney microsomes, it yields corresponding cysteine derivatives. This compound is primarily utilized in research focused on the glutathionase system and the metabolic pathways involved in glutathione degradation. -
Glutathionase Inhibitor
S-Benzylglutathione is a competitive inhibitor of glutathionase, a key enzyme involved in the metabolism of glutathione. Its metabolism by rat kidney microsomes yields corresponding cysteine derivatives. This reagent is valuable for research into the metabolic breakdown of glutathione and the role of the glutathionase system in cellular processes. -
Corrosion Inhibitor
IZS-M is an amino acid-derived corrosion inhibitor designed using green chemistry principles. It effectively reduces the corrosion of mild steel by forming a protective film on the metal surface. Research indicates that IZS-M demonstrates a corrosion inhibition efficiency of 67.19%, making it a valuable tool for studies focused on metal protection and sustainability in various industrial applications.
