Oximidine III is an antitumor antibiotic that selectively inhibits the growth of 3Y1 rat fibroblast cells, demonstrating significant effects on various tumor-associated genes. It targets both v-H-ras-3Y1 and v-src-3Y1 cells, with IC50 values of 14 nM and 4.5 nM, respectively, while normal 3Y1 cells show an IC50 of 140 nM. Oximidine III effectively halts the cell cycle at the G1 phase in RAS or SRC-activated cells and promotes the expression of p21WAF1, making it valuable for research in cancer biology and therapeutic development.
Oximidine III is an antitumor antibiotic that selectively inhibits the growth of 3Y1 rat fibroblast cells, demonstrating significant effects on various tumor-associated genes. It targets both v-H-ras-3Y1 and v-src-3Y1 cells, with IC50 values of 14 nM and 4.5 nM, respectively, while normal 3Y1 cells show an IC50 of 140 nM. Oximidine III effectively halts the cell cycle at the G1 phase in RAS or SRC-activated cells and promotes the expression of p21WAF1, making it valuable for research in cancer biology and therapeutic development.
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