Perifosine (NSC-639966)

Catalog No.: A10709

Akt inhibitor

Perifosine (NSC-639966)

Perifosine (NSC-639966) Chemical Structure

CAS NO. 157716-52-4

Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$80.00
50 mg
$270.00
200 mg
$950.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Bjune K, .et al. Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms, PLoS One, 2019, Jun 19;14(6):e0218537 PMID: 31216345
  • Kyoung-Jae Won, .et al. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells, Cell Death Dis, 2017, Jan; 8(1): e2554 PMID: 28079882
  • Zhipeng Li, .et al. A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell carcinoma proliferation, Oncotarget, 2016, May 31; 7(22): 31892–31906 PMID: 26895469
  • Won KJ, .et al. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription., Apoptosis., 2014, Jan;19(1):179-90 PMID: 24085402

Biological Activity

Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
Targets
Akt (MM.1S cells)
4.7 μM
In vitro (25°C) DMSO <1 mg/mL (<1 mM)
Water 8 mg/mL (17.32 mM)
Ethanol 15 mg/mL (32.49 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.66 mL 108.3 mL 216.59 mL
0.5 mM 4.33 mL 21.66 mL 43.32 mL
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10709
Actions Inhibitor
M. Wt 461.7
Formula C25H52NO4P
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 157716-52-4
Synonyms KRX-0401,NSC 639966
SMILES CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

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