PIK-III

Catalog No.: A15868

Autophagy Inhibitor

PIK-III

PIK-III Chemical Structure

CAS NO. 1383716-40-2

PIK-III is a selective inhibitor of ?VPS34 enzymatic activity.

Availability: In stock

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5 mg

Regular Price: $130.00

Special Price $104.00

10 mg

Regular Price: $210.00

Special Price $168.00

25 mg

Regular Price: $470.00

Special Price $376.00

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Biological Activity

PIK-III is a selective inhibitor of ?VPS34 enzymatic activity.
Targets
Target Value
Vps34IC50: 0.018μM
PI3KδIC50: 1.2μM
PI3KγIC50: 3.04μM
PI3KαIC50: 3.96μM
PI4KβIC50: 4.43μM
PI3KβIC50: >9.1μM
mTORIC50: >9.1μM
In vitro DMSO 56 mg/mL (175.34 mM)
Water Insoluble
Ethanol 56 mg/mL (175.34 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.31 mL 156.56 mL 313.13 mL
0.5 mM 6.26 mL 31.31 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15868
Actions Inhibitor
CAS No. 1383716-40-2
Formula C17H17N7
M. Wt 319.36
Purity >98%
Synonyms VPS34-IN2
SMILES NC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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