Plazomicin is a semi-synthetic aminoglycoside antibiotic that targets bacterial ribosomes by inhibiting protein synthesis. It serves as a substrate for aminoglycoside acetyltransferase and aminoglycoside phosphotransferase, yet remains resistant to common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K and demonstrates significant activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales, making it valuable for research in antibiotic resistance and treatment efficacy studies.
Plazomicin is a semi-synthetic aminoglycoside antibiotic that targets bacterial ribosomes by inhibiting protein synthesis. It serves as a substrate for aminoglycoside acetyltransferase and aminoglycoside phosphotransferase, yet remains resistant to common aminoglycoside-modifying enzymes. Plazomicin selectively inhibits MATE2-K and demonstrates significant activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales, making it valuable for research in antibiotic resistance and treatment efficacy studies.
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