Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for Target Protein for PROTAC
BMS-1166-N-piperidine-COOH is a ligand designed to target E3 ligase for PROTAC applications. This compound serves as a key component in the synthesis of PD-1/PD-L1 degrader-1, which facilitates the degradation of the PD-1/PD-L1 complex, a crucial immune checkpoint. With a potent PD-1/PD-L1 interaction inhibition demonstrated by an IC50 of 1.4 nM, BMS-1166-N-piperidine-COOH effectively reverses the suppressive effects of the PD-1/PD-L1 pathway on T cell activation, making it valuable for cancer immunotherapy research. -
Ligands for Target Protein for PROTAC
PROTAC IRAK4 ligand-1 is a synthetic ligand specifically designed to target interleukin-1 receptor-associated kinase 4 (IRAK4). This compound plays a critical role in the development of PROTAC IRAK4 degrader-1, facilitating targeted protein degradation. Its primary applications include cancer research and studies investigating inflammatory pathways, making it a valuable tool for researchers exploring IRAK4-related signaling mechanisms. -
Ligands for Target Protein for PROTAC
A-1210477-piperazinyl is a ligand that specifically binds to myeloid cell leukemia 1 (MCL1), serving as a crucial component in PROTAC (proteolysis-targeting chimeras) technology. This compound plays a significant role in targeted protein degradation research, enabling the modulation of MCL1 levels in various cellular contexts. A-1210477-piperazinyl is valuable for studies aimed at understanding MCL1's involvement in cell survival and cancer biology. -
Ligands for Target Protein for PROTAC
CDK2 ligand-2 is a selective ligand targeting cyclin-dependent kinase 2 (CDK2), facilitating the synthesis of PROTAC (proteolysis targeting chimera) molecules. By combining CDK2 ligand-2 with E3 Ligase Ligand-linker Conjugate 184, researchers can create CDK2 degrader 2, a potent tool for targeted protein degradation studies. This compound is valuable for investigating CDK2's role in cell cycle regulation and exploring therapeutic strategies in cancer research. -
Ligands for Target Protein for PROTAC
AR Antagonist 14 is a potent ligand for specific target proteins utilized in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the development of targeted protein degraders, allowing for the selective degradation of androgen receptors. AR Antagonist 14 can be effectively combined with VH 101-amide-piperidine-Pip-alkyne to synthesize PROTAC degraders, enhancing research on targeted therapies in cancer and other diseases. -
Ligands for Target Protein for PROTAC
KAL-21404358 is a ligand designed for specific binding to target proteins for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the targeted degradation of proteins, providing valuable insights into protein function and regulation. Research applications include the study of protein-protein interactions and the development of targeted therapies in cancer and other diseases. KAL-21404358 supports the advancement of innovative approaches in drug discovery and biological research. -
Ligands for Target Protein for PROTAC
PTPN2 ligand 1 is a specific ligand designed for the PTPN2 target protein, facilitating the development of PROTAC (proteolysis-targeting chimeras). This compound plays a crucial role in research applications focused on targeted protein degradation, providing researchers with the means to investigate the functional relevance of PTPN2 in various biological processes. Additionally, it serves as a synthetic precursor for the compound PVD-06, contributing to further studies in protein modulation. -
Ligands for Target Protein for PROTACs
Palbociclib-CH2COOH is a ligand designed for the Target Protein in PROTAC applications. This compound can function as an active control for evaluating the target protein ligand interactions of CPD-39 and CPD-10. Its specificity and binding capacity make it a valuable tool for researchers investigating targeted protein degradation and related pathways. -
Ligands for Target Protein for PROTAC
PXR Ligand 3 is a ligand for the Pregnane X Receptor (PXR), acting as a critical component in the development of PROTAC (Proteolysis Targeting Chimera) molecules. It facilitates the recruitment of E3 ubiquitin ligases, thereby promoting targeted degradation of specific proteins. This compound is valuable in drug discovery and biochemical research, particularly in studies focused on the modulation of PXR activity and the development of PROTAC-based therapeutics. -
Ligands for Target Protein for PROTACs
IRAK4 ligand-12 is a ligand for interleukin-1 receptor-associated kinase 4 (IRAK4), designed for use in PROTAC (proteolysis targeting chimeras) applications. This compound plays a critical role in the selective degradation of IRAK4, thus enabling the modulation of immune response pathways. It is particularly useful in research focused on inflammation and cancer, facilitating studies on targeted protein degradation strategies. IRAK4 ligand-12 can also be utilized in the synthesis of KTX-951, contributing to advancements in therapeutic development. -
Ligands for Target Protein for PROTAC
SHP2 ligand-3 is a ligand specifically designed for the SHP2 target protein, facilitating the synthesis of SHP2 protein degrader-1. This compound serves as an essential tool in targeted protein degradation studies, enabling the selective degradation of SHP2. Its application in PROTAC technology allows researchers to investigate the functional roles of SHP2 in cellular processes and disease mechanisms, supporting drug discovery and development efforts. -
Ligands for Target Protein for PROTAC
BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) serves as a versatile ligand for target proteins in PROTAC applications. This compound incorporates a sulfonamide linker designed to enhance the solubility of linker-conjugates. It is particularly useful in the synthesis of PROTACs aimed at inducing targeted degradation of proteins with potential antitumor activity. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-6 is a small molecule ligand specific for the SMARCA2 and SMARCA4 proteins, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) technology. This compound can be utilized in the development of PROTACs aimed at studying the roles of these epigenetic regulators in cancer biology and other diseases. SMARCA2/4-ligand-6 is a valuable tool for researchers investigating targeted therapeutic strategies and protein homeostasis. -
Ligands for Target Protein for PROTAC
BTK-IN-39 is a ligand targeting Bruton’s tyrosine kinase (BTK), designed for the synthesis of PROTAC BTK Degrader-11. This compound enables the selective degradation of BTK, facilitating studies on its biological functions and role in disease models, particularly in hematological malignancies. Its application in PROTAC technology allows for innovative approaches to therapeutic intervention by modulating protein levels within cells. -
Ligands for Target Protein for PROTAC
HDAC8-IN-11 is a potent inhibitor of histone deacetylase 8 (HDAC8), a key regulator of gene expression and cellular processes. This compound demonstrates significant biological activity by modulating acetylation levels of histones and non-histone proteins. HDAC8-IN-11 is primarily utilized in research applications focused on targeted protein degradation via PROTAC technology, facilitating the selective degradation of specific proteins in cellular models. -
Ligands for Target Protein for PROTAC
HG-7-85-01-Decyclopropane is a ligand for target proteins utilized in the PROTAC (Proteolysis Targeting Chimera) technology. This compound features the ABL inhibitor moiety and binds to IAP (inhibitor of apoptosis protein) ligands through a linker, enabling the targeted degradation of specific proteins within cells. Its application in research includes elucidating protein function and pathway regulation, making it a valuable tool in cancer biology and therapeutic development. -
Ligands for Target Protein for PROTAC
mTOR ligand 1 is a potent ligand targeting the mechanistic target of rapamycin (mTOR) for use in PROTAC (Proteolysis Targeting Chimera) applications. This compound plays a crucial role in the degradation of mTOR through the ubiquitin-proteasome system, enabling selective modulation of mTOR activity. mTOR ligand 1 is ideal for research involving mTOR signaling pathways and related cellular processes, providing a valuable tool for investigating therapeutic strategies in cancer and metabolic disorders. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-4 acts as a ligand for the SMARCA2 and SMARCA4 proteins, serving as an essential component for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of proteins associated with various cellular processes, providing a powerful tool for drug discovery and therapeutic research. SMARCA2/4-ligand-4 is integral to the synthesis of PROTAC SMARCA2/4 degrader-36, enabling investigations into the modulation of oncogenic pathways and protein homeostasis. -
Ligands for Target Protein for PROTAC
Multi Kinase Ligand 4 is a selective ligand designed for the synthesis of PROTACs, specifically PROTAC DB-0646. This compound plays a crucial role in modulating protein degradation pathways, facilitating targeted protein degradation through the ubiquitin-proteasome system. Its applications extend to drug discovery and development in cancer research, enabling investigations into the regulation of kinase activity and potential therapeutic interventions. -
Ligands for Target Protein for PROTAC
SMARCA2 ligand-7 is a specific ligand for SMARCA2, a key protein involved in chromatin remodeling. This compound is designed for use in PROTAC (PROteolysis TArgeting Chimeras) studies, facilitating targeted protein degradation. SMARCA2 ligand-7 enables researchers to investigate the functional roles of SMARCA2 in cellular processes and its potential as a therapeutic target in various diseases. -
Ligands for Target Protein for PROTAC
Demethyl-RSL3-boc is a ligand designed for targeted protein degradation through PROTAC (Proteolysis Targeting Chimeras) technology. This compound effectively interacts with target proteins to facilitate their ubiquitin-mediated degradation, thereby modulating cellular pathways. Demethyl-RSL3-boc is utilized in research applications focused on studying protein dynamics and developing novel therapeutic strategies for various diseases, including cancer. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-1 is a selective ligand for the proteins SMARCA2 and SMARCA4, facilitating targeted protein degradation via PROTAC (Proteolysis Targeting Chimeras) technology. This compound exhibits promising biological activity by promoting the ubquitination and subsequent degradation of these target proteins. It is designed for use in research applications focusing on gene regulation, chromatin remodeling, and the study of protein homeostasis. -
Ligands for Target Protein for PROTAC
SMARCA2 ligand-6 is a selective ligand for the SMARCA2 protein, functioning within the context of proteolysis-targeting chimera (PROTAC) technology. This compound facilitates the targeted degradation of SMARCA2, enabling researchers to study its biological functions and roles in various cellular processes. It is a valuable tool for investigating therapeutic strategies in cancer and other diseases linked to dysregulation of chromatin remodeling factors. -
Ligands for Target Protein for PROTAC
LC3B ligand 1 is a specific ligand for the target protein utilized in PROTAC technology. It plays a crucial role in synthesizing PROTAC CDK9 autophagic degrader 1, facilitating targeted protein degradation through autophagy. This compound is valuable in studies aimed at investigating protein turnover, cellular homeostasis, and the potential therapeutic applications of PROTACs in cancer and other diseases. -
SMARCA2 Ligand
SMARCA2 ligand-8 acts as a selective ligand for the target protein SMARCA2, facilitating the synthesis of the PROTAC SMARCA2/4-degrader-35. This compound is instrumental in research applications focused on targeted protein degradation, offering insights into the modulation of gene regulation and chromatin remodeling. Its utility in developing innovative degraders highlights its significance in the study of cancer biology and potential therapeutic interventions. -
Ligands for Target Protein for PROTAC
AKT ligand-2 is a selective ligand targeting the AKT protein. It can be utilized in the synthesis of PROTACs, specifically by linking with VHL ligand (S,R,S)-AHPC, to create compounds like PROTAC MS21. This reagent is instrumental in cellular research focused on targeted protein degradation and the modulation of AKT signaling pathways. -
Ligands for Target Protein for PROTACs
TRIB2 ligand-1 is a specific ligand for the TRIB2 protein, facilitating the development of PROTACs designed for targeted protein degradation. This compound plays a crucial role in the synthesis of PROTAC TRIB2 degrader-1, which can be employed in research focused on protein regulation and degradation pathways. Its application in such studies supports investigations into various cellular mechanisms and potential therapeutic targets. -
Ligands for Target Protein for PROTAC
SMARCA2/4-ligand-2 is a selective ligand designed for the targeted degradation of SMARCA2 and SMARCA4 proteins via the PROTAC (proteolysis-targeting chimeras) approach. This compound facilitates the ubiquitination and subsequent proteasomal degradation of these essential chromatin remodeling proteins, making it a valuable tool in studies focused on cancer biology and epigenetic regulation. Researchers can utilize SMARCA2/4-ligand-2 to investigate the role of SMARCA2/4 in various cellular processes and to explore therapeutic strategies for diseases linked to their dysregulation. -
Ligand for Target Protein for PROTAC
Nrf2 activator-22 is a ligand specifically targeting the Nrf2 protein, playing a crucial role in the development of PROTAC-based therapeutics. This compound facilitates the synthesis of PROTAC K-Ras Degrader-7, highlighting its potential in targeted protein degradation research. Nrf2 activator-22 is valuable for studies aimed at manipulating oxidative stress responses and related signaling pathways.
