Desmethyl-QCA276

Name: Desmethyl-QCA276
Brand: Adooq Bioscience
SKU: A20648
Rating: 5 (288 reviews)

Catalog No.: A20648

Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.

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Grouped product items
Size	Price	Stock
1mg	$320.00	In stock
5mg	$960.00	In stock
10mg	$1,600.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM.

Product Information

Catalog Num	A20648
Formula	C21H17N5OS
Molecular Weight	387.46
CAS Number	2126819-55-2
SMILES	CC1=NN=C2COCC(C(CC3=CC=CC=C3)=C(C#CC4=CNN=C4)S5)=C5N21
Synonyms	PROTAC BRD4-binding moiety 4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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