Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Ethyl 2-(2-iodoethoxy)acetate serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting the formation of a ternary complex with an E3 ligase. Its applications are pivotal in drug discovery and development, particularly for studying protein degradation pathways in various biological contexts. -
PROTAC Linker
2-(6-Bromohexyloxy)tetrahydro-2H-pyran is a key linker for PROTAC (Proteolysis Targeting Chimeras) technology. This compound facilitates the generation of bifunctional degraders, enabling targeted protein degradation by connecting a E3 ligase ligand to a target protein ligand. Its use in PROTAC synthesis supports research applications in cancer therapeutics and cellular pathway modulation, offering insights into protein function and regulation. -
PROTAC Linker
Biotin-PEG3-OH is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that promote the degradation of specific proteins within cells, allowing for targeted protein modulation in biological research. Its unique properties enhance solubility and enable efficient conjugation to protein-binding ligands, making it a valuable tool in the study of targeted protein degradation mechanisms and therapeutic development. -
PROTAC Linker
Potassium succinate trihydrate serves as a versatile PROTAC linker, facilitating the design and synthesis of protein-targeting chimeras. Its unique structure enables effective conjugation between target proteins and E3 ligases, crucial for the targeted degradation of proteins within cellular pathways. This reagent is essential in research applications focusing on drug discovery and the development of novel therapeutic strategies involving targeted protein degradation. -
PROTAC Linker
m-PEG5-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of protein ligands to E3 ligases, enhancing the targeted degradation of specific proteins within the cell. m-PEG5-Hydrazide is essential for researchers aiming to develop novel therapeutic strategies through targeted protein modulation and degradation. -
PROTAC Linker
4-((4-Iodobenzyl)oxy)piperidine hydrochloride serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This chemical compound is critical for the effective assembly of PROTACs designed to induce targeted protein degradation, enhancing research in cancer biology and therapeutic development. Its role promotes efficient recruitment of E3 ligases, making it an essential component for studies focused on protein regulation mechanisms. -
PROTAC Linker
Tert-butyl (3-azaspiro[5.5]undecan-9-yl)carbamate is a PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound is crucial for conjugating ligands to E3 ubiquitin ligases, thereby promoting targeted protein degradation. It is a valuable tool in chemical biology research, enabling investigations into protein function and therapeutic interventions for diseases associated with protein dysregulation. -
PROTAC Linker
Dimethyl trans-1,4-cyclohexanedicarboxylate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of heterobifunctional molecules that promote targeted protein degradation by linking a target ligand to an E3 ligase ligand. Its role is crucial in advancing research in targeted protein modulation and therapeutic intervention strategies. -
PROTAC Linker
Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate is a specialized PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, promoting targeted degradation of specific proteins. Its key biological application lies in advancing research in protein modulation and therapeutic development, particularly in cancer biology and cellular signaling pathways. -
PROTAC Linker
tert-Butyl (2-(2-(aminooxy)ethoxy)ethyl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. It is valuable in studies related to targeted protein degradation and therapeutic development. -
PROTAC Linker
Methyl 3-iodopropiolate is a PROTAC linker that facilitates the targeted degradation of proteins through the ubiquitin-proteasome system. Its reactive iodopropiolate moiety enables efficient conjugation to protein ligands, supporting the development of novel bifunctional molecules in drug discovery. This compound is essential for advancing research applications focused on targeted protein degradation and therapeutic intervention. -
PROTAC Linker
Cbz-azaspiro[3.3]heptane-OH is a specialized PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, thereby promoting their degradation via the ubiquitin-proteasome pathway. Its unique structure enhances the efficiency and specificity of PROTACs, making it a valuable tool in drug development and molecular biology research. -
PROTAC Linker
H2N-PEG2-CH2COOH hydrochloride is a versatile linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves facilitating the conjugation of target proteins to E3 ligases, enhancing the selective degradation of specific proteins within cells. This compound serves as a critical component in chemical biology research, advancing the field of targeted protein degradation. -
PROTAC Linker
1-(Piperidin-4-ylmethyl)piperidine is a chemical compound utilized as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs that target specific proteins for degradation, such as PROTAC BTK Degrader-9. Its role as a versatile linker makes it valuable for research applications in targeted protein degradation studies. -
PROTAC Linker
tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate is a PROTAC linker designed for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to specific target proteins, enabling targeted degradation and modulation of protein levels within cells. Its versatile structure makes it an essential component in chemical biology research focused on proteostasis and therapeutic interventions. -
PROTAC Linker
2-(Piperidin-4-yl)-acetic acid ethyl ester serves as a PROTAC linker, critical for the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases to target proteins, leading to targeted degradation. Its application in synthetic biology and medicinal chemistry supports innovative research in targeted protein modulation and therapeutic development. -
PROTAC Linker
Hydroxy-PEG3-I is a PROTAC linker designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and pharmacokinetic properties of PROTACs, allowing for effective modulation of targeted protein degradation. Its hydrophilic nature contributes to improved cellular uptake and bioavailability, making it a valuable tool for researchers investigating targeted protein therapy and degradation pathways. -
PROTAC Linker
Benzyl 4-(3-hydroxypropyl)piperidine-1-carboxylate is a versatile PROTAC linker that facilitates the development of targeted protein degradation strategies. This compound is essential for connecting E3 ligases with target proteins, enabling selective degradation in cellular systems. Its application extends to various areas of biological research, particularly in studies aiming to modulate protein levels and investigate cellular pathways through targeted protein degradation. -
PROTAC Linker
(1R,3R)-3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol phosphate is a specialized linker utilized in the construction of proteolysis-targeting chimeras (PROTACs). This reagent plays a crucial role in enhancing the efficacy of targeted protein degradation by facilitating the selective recruitment of E3 ligases to target proteins. Its application is essential in research focused on developing novel therapeutic strategies that leverage the ubiquitin-proteasome system for selectively degrading disease-related proteins. -
PROTAC Linker
TsO-PEG3-NH-CO-OBn is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, thereby improving their efficacy in the targeted degradation of specific proteins. It is suitable for use in various research applications focused on protein regulation and therapeutic intervention strategies. -
PROTAC Linker
(((7-Bromoheptyl)oxy)methyl)benzene is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that can induce targeted degradation of specific proteins, making it valuable in various biological research applications, including drug development and cellular signaling studies. Its unique structure enables efficient conjugation with both target proteins and E3 ligases, enhancing the specificity and efficacy of targeted protein degradation strategies. -
PROTAC Linker
tert-Butyl (6-oxohexyl)carbamate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables site-specific recruitment of E3 ubiquitin ligases, enhancing targeted protein degradation processes. Its key applications include chemical biology and drug discovery, particularly in studying protein interactions and degradation pathways. -
PROTAC Linker
1-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid serves as an effective PROTAC linker, facilitating targeted protein degradation. This compound is essential for the synthesis of DYR684, contributing to the advancement of research in cellular regulation and therapeutic development. Utilizing this linker in PROTAC design can enhance the efficacy and specificity of target protein modulation in various biological studies. -
PROTAC Linker
3-Hydroxypropyl 4-methylbenzenesulfonate is a PROTAC linker designed for the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates targeted protein degradation through the recruitment of E3 ligases, enabling selective modulation of protein levels in cellular systems. Its application in PROTAC development makes it a valuable reagent for research in targeted protein degradation and therapeutic interventions. -
PROTAC Linker
tert-Butyl 3-(azetidin-3-yl)pyrrolidine-1-carboxylate functions as a PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a critical role in targeted protein degradation research, enabling the selective ubiquitination and degradation of specific proteins. Its use in PROTAC development supports studies in various fields, including cancer biology and drug discovery, by providing innovative strategies for modulating protein activity. -
PROTAC Linker
PEG3-bis-NHMe is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the assembly of bifunctional molecules that recruit E3 ligases to target proteins for ubiquitination and subsequent proteasomal degradation. PEG3-bis-NHMe is integral for researchers aiming to study targeted protein degradation and its potential therapeutic applications in various diseases. -
PROTAC Linker
Ethyl 5-chloropentanoate is a PROTAC linker designed to facilitate the synthesis of targeted protein degraders. This compound plays a crucial role in the development of PROTACs, enabling the selective degradation of specific proteins within cellular pathways. Its incorporation into PROTAC modules supports research applications in drug discovery and therapeutic interventions targeting various diseases. -
PROTAC Linker
NH2-PEG7-C-COOH is a PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of conjugated molecules, enabling targeted protein degradation. Its unique structure supports versatile applications in drug development and chemical biology research, particularly in studies aiming to modulate protein levels through the ubiquitin-proteasome pathway. -
PROTAC Linker
MS-PEG3-O-MS is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase binding domains, enabling selective degradation of specific proteins. Its application in PROTAC development aids in exploring targeted protein degradation for therapeutic interventions in various disease models. -
PROTAC Linker
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc serves as a PROTAC linker, facilitating targeted protein degradation through the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of PROTAC SMARCA2/4-degrader-35, enhancing the selective degradation of specific proteins associated with various cellular processes. Its application in research enables the exploration of protein functions and therapeutic strategies in the field of targeted protein modulation. -
PROTAC Linker
(4-Bromobutyl)boronic acid serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient targeting and degradation of specific proteins by linking E3 ligases to the protein of interest. Its versatility supports research applications in targeted protein degradation and the development of innovative therapeutic strategies in drug discovery. -
PROTAC Linkers
NH2-PEG6-C1-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. It facilitates the construction of bifunctional molecules that recruit E3 ligases to target proteins for degradation, thereby enabling targeted protein modulation. This reagent is essential for researchers developing novel therapeutic strategies in targeted protein degradation and related fields. -
PROTAC Linker
1,4-Bis((tetrahydrofuran-2-yl)oxy)butane serves as a PROTAC (Proteolysis Targeting Chimera) linker, facilitating the development of novel PROTACs for targeted protein degradation. Its structural characteristics enhance the conjugation of target proteins with E3 ligases, enabling the selective ubiquitination and proteasomal degradation of specific cellular proteins. This compound is valuable for researchers investigating targeted therapeutics and studying complex biological pathways involving protein regulation. -
PROTAC Linker
4-Mercaptobutanoic acid is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases and enables targeted degradation of specific proteins, making it a valuable tool in chemical biology and drug discovery. Its application in PROTAC technology aids in the development of innovative therapeutic strategies for various diseases. -
PROTAC Linker
Tert-butyl (7-bromoheptyl)(methyl)carbamate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras. Its unique structural properties enhance the binding affinity and stability of protein targets, making it valuable in pharmacological research. This compound is pivotal in the synthesis of novel PROTACs aimed at targeted protein degradation, advancing therapeutic strategies in various diseases. -
PROTAC Linker
Methyl (1S,2R)-2-(2-hydroxyethyl)cyclopropane-1-carboxylate serves as a PROTAC linker, facilitating the development of PROTAC molecules that induce targeted degradation of specific proteins. Its structural properties support the effective conjugation of targeting moieties to E3 ligase recruiters, enhancing the efficiency of protein modulation in cellular contexts. This compound is suitable for research applications in drug discovery and the study of protein homeostasis. -
PROTAC Linker
1'-[(tert-Butoxy)carbonyl]-[1,3'-biazetidine]-3-carboxylic acid serves as a PROTAC linker essential for the development of targeted protein degradation strategies. By facilitating the assembly of E3 ligase and target proteins, this compound enhances the efficacy of PROTACs in modulating cellular protein levels. Its unique structural properties make it a valuable tool for chemical biology research focused on targeted therapies. -
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems. -
PROTAC Linker
4-(4-Methoxyphenyl)-1-butanol serves as a PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential in the synthesis of PROTACs, which are designed to selectively degrade specific proteins within cells, thus advancing research in targeted protein degradation and therapeutic interventions. Its unique structure allows for optimal integration into various PROTAC constructs, enhancing their efficacy in biological applications. -
PROTAC Linker
Boc-NH-C5-NH-Me is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficacy of targeted degradation by linking E3 ligases to target proteins. It is instrumental in chemical biology research, particularly in studies focusing on targeted protein degradation and the modulation of cellular pathways. -
PROTAC Linker
4-(2-Aminoethoxy)benzoic acid hydrochloride is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, making it a valuable tool in targeted protein modulation research. Its unique structure enables efficient conjugation to E3 ligase ligands and protein of interest, supporting applications in drug discovery and development focused on protein degradation strategies. -
PROTAC Linker
Methyl 6-{[(tert-butoxy)carbonyl]amino}spiro[3.3]heptane-2-carboxylate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound enhances the selective degradation of proteins by incorporating E3 ligase-recruiting elements, thereby contributing to targeted protein modulation in research. Its utility in synthesizing advanced PROTACs makes it a valuable reagent for biochemical studies focused on targeted protein degradation. -
PROTAC Linker
3,3'-(Piperazine-1,4-diyl)dipropanoic acid functions as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation. This compound allows for the effective conjugation of ligands to E3 ligases, thereby enhancing the specificity and efficacy of PROTAC molecules in various biological research applications. Its unique structure supports the exploration of protein modulation strategies in cellular assays and therapeutic contexts. -
PROTAC Linker
Methyl 2-(4-(hydroxymethyl)phenyl)acetate serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This reagent aids in the selective degradation of target proteins, making it valuable in chemical biology and therapeutic research. Its effectiveness enhances the development of innovative strategies for targeted protein modulation and degradation in various disease models. -
PROTAC Linker
(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate serves as a PROTAC linker facilitating the bioconjugation of target proteins for targeted protein degradation. This compound provides a scaffold for the development of innovative PROTACs, enabling researchers to explore the modulation of protein levels within cellular systems. Its structural features are designed to enhance the efficiency and specificity of protein targeting in therapeutic applications. -
PROTAC Linker
tert-Butyl 4-(3-bromopropyl)piperazine-1-carboxylate oxalate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing the degradation of target proteins via the ubiquitin-proteasome pathway. Its structural features support effective assembly of tandem moieties, making it essential for research applications in targeted protein degradation and related therapeutic strategies. -
PROTAC Linkers
Mal-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-derived linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient assembly of PROTAC molecules, enabling targeted protein degradation through the recruitment of E3 ligases. Research applications include studying protein regulation, exploring new therapeutic strategies for diseases, and advancing drug discovery efforts. -
PROTAC Linker
tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1) serves as a PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This reagent plays a crucial role in selective degradation of target proteins via the ubiquitin-proteasome system. It is essential in research applications aimed at investigating targeted protein degradation and exploring therapeutic pathways in various diseases. -
PROTAC Linker
Boc-NH-PEG2-CH2COOH (dicyclohexylamine) serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). It enhances the solubility and stability of the resultant molecules, thereby improving their biochemical properties. This linker is pivotal for research applications that aim to regulate protein degradation through targeted proteolysis. -
PROTAC Linker
3-(4-Bromophenoxy)propanenitrile functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. Its unique structure allows for effective conjugation to protein-targeting moieties, enhancing the stability and efficacy of PROTACs in selective protein degradation studies. This compound is essential for research applications in drug discovery and development, particularly in the field of therapeutic interventions targeting specific proteins.
