TCO4-PEG2-Maleimide

Catalog No.: A84227
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems.
Product Information
Catalog NumA84227
FormulaC22H33N3O7
Molecular Weight451.51
CAS Number2141981-85-1
SMILESO=C(OC1CC/C=C/CCC1)NCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O
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