Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
4-Amino-cyclohexanecarboxylic acid methyl ester hydrochloride serves as a key linker in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the conjugation of target proteins to E3 ligases, facilitating the ubiquitination and subsequent degradation of specific proteins. It is essential for researchers developing targeted protein degradation strategies in various biological studies and therapeutic applications. -
PROTAC Linker
2-(4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid is a versatile linker utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its structure enables efficient conjugation of target proteins and E3 ligases, facilitating targeted protein degradation. This compound serves as a valuable tool in drug discovery and development, particularly in studies focusing on the modulation of cellular protein levels. -
PROTAC Linkers
N'-Boc-N-(Gly-Oleoyl)-Lys is a specialized linker designed for use in PROTAC (proteolysis-targeting chimera) assembly. This compound features an alkyl chain that enhances hydrophobic interactions, facilitating the effective targeting and degradation of specific proteins within cells. It is particularly valuable for researchers synthesizing diverse PROTACs aimed at modulating protein levels for therapeutic purposes. -
PROTAC Linker
Propargyl-(trans)-cyclohexanediamine-Boc is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent connection between a protein of interest and an E3 ligase, enhancing targeted protein degradation. Its application in research supports the development of innovative therapeutic strategies in oncology and other fields by enabling selective degradation of disease-associated proteins. -
PROTAC Linker
Diethyl octanedioate functions as a PROTAC linker, instrumental in the synthesis of proteolysis-targeting chimeras (PROTACs). This chemical scaffold enhances the stability and efficacy of designed PROTACs, facilitating targeted protein degradation. Its application is significant in studying protein interactions and developing therapeutic modalities aimed at modulating cellular processes through targeted degradation. -
PROTAC Linker
Methyl 3-((tert-butoxycarbonyl)amino)propanoate serves as a PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound is essential in the design and synthesis of PROTAC molecules, which harness the ubiquitin-proteasome system to selectively degrade target proteins. Its application is pivotal in advancing therapeutic strategies in cancer research and drug discovery by enabling targeted protein degradation. -
PROTAC Linker
Methyl 6-(chlorosulfonyl)hexanoate is a critical PROTAC linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic agents by enabling targeted protein degradation. Its structural characteristics support efficient conjugation to both ligand and E3 ligase, making it a valuable tool in drug discovery and development research. -
PROTAC Linkers
Mal-NH-PEG12-CH2CH2COOPFP ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of warheads to E3 ligases, enhancing the efficiency of target protein degradation. Mal-NH-PEG12-CH2CH2COOPFP ester is ideal for applications in targeted protein degradation research and therapeutic development. -
PROTAC Linker
1,4-Phenylenedimethanamine dihydrochloride functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for constructing bifunctional molecules that induce targeted degradation of specific proteins, enhancing the study of protein function and cellular mechanisms. Its application in chemical biology enables researchers to explore innovative therapeutic strategies by modulating protein levels within various biological systems. -
PROTAC Linker
Heptacosanedioic Acid is a PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). By linking E3 ligases to target proteins, it enhances targeted degradation pathways within cells. This compound is instrumental in research applications focusing on protein regulation and degradation, providing insights into various cellular processes and diseases. -
PROTAC Linker
6-Bromohexanoyl Chloride is a versatile PROTAC linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the assembly of proteins for targeted degradation, thereby enhancing the study of protein regulation in various biological processes. This compound is integral for researchers developing novel therapeutic strategies aimed at modulating specific protein levels in cellular environments. -
PROTAC Linker
tert-Butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This reagent aids in the construction of bifunctional molecules that can selectively degrade target proteins, making it valuable in drug discovery and therapeutic research, particularly for optimizing protein degradation pathways. -
PROTAC Linker
Sebacic acid monomethyl ester is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound is essential for establishing the molecular connections necessary to selectively direct protein degradation, enhancing the study of protein function and therapeutic mechanisms. Its structural properties make it suitable for various applications in chemical biology and drug discovery processes. -
PROTAC Linker
PIP-C-3-Azaspiro[5.5]undecane-boc serves as a pivotal linker in the development of PROTAC (Proteolysis Targeting Chimera) molecules. This compound is essential for the synthesis of the PROTAC SOS1 degrader-10, contributing to targeted protein degradation studies. Its unique structural features facilitate effective protein recruitment and degradation, making it a valuable tool for researchers in exploring novel therapeutic strategies. -
PROTAC Linker
Tert-butyl (4-((tert-butoxycarbonyl)amino)phenethyl)carbamate serves as a PROTAC linker, facilitating the development of targeted protein degradation therapeutics. This compound plays a crucial role in the synthesis of PROTAC molecules by enabling the conjugation of targeting ligands to E3 ligases. Its utility in chemical biology aids researchers in exploring novel methods for protein modulation and degradation in various biological systems. -
PROTAC Linkers
Fmoc-NH-PEG15-CH2CH2COOH is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of Proteolysis-Targeting Chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins to E3 ligases, promoting the degradation of specific proteins within cells. It is suitable for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
PROTAC Linker
Ethyl 3-aminopropanoate is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimera (PROTAC) molecules. By connecting ligand-modified targets with E3 ligase recruiters, this compound enables selective ubiquitination and subsequent degradation of specific proteins. Its application in PROTAC development enhances research in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linker
Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic agents by promoting selective degradation of target proteins. Its utility in chemical biology research makes it valuable for studying protein turnover and the modulation of cellular pathways. -
PROTAC Linker
Ethyl 5-bromo-4-oxopentanoate serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the development of novel therapeutic strategies by enabling targeted degradation of specific proteins within cellular contexts. Its application in PROTAC assembly makes it a valuable reagent in chemical biology and drug design research. -
PROTAC Linker
19-Hydroxynonadecanoic acid serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeting and degradation of specific proteins, thereby playing a crucial role in protein modulation studies. It is primarily utilized in the synthesis of innovative therapeutic agents designed for targeted protein degradation research. -
PROTAC Linker
Boc-PEG3-O-methyl acetate is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of target proteins and E3 ubiquitin ligases, enhancing the efficiency of targeted protein degradation. This versatile linker is particularly useful in chemical biology and drug discovery applications focused on targeted protein modulation. -
PROTAC Linker
Methyl 4-((tert-butoxycarbonyl)amino)butanoate is a PROTAC linker that facilitates the development of targeted protein degradation systems. This compound plays a crucial role in synthesizing PROTACs, enabling the selective degradation of specific proteins, thus providing valuable insights into protein function and regulation. Its application in chemical biology research supports advancements in therapeutic strategies aimed at diverse diseases. -
PROTAC Linker
Tert-butyl (3-cyanopropyl)(methyl)carbamate functions as a PROTAC linker, facilitating the creation of protein-targeting chimeras. This compound is essential for developing Proteolysis Targeting Chimeras (PROTACs), which are utilized in targeted protein degradation studies. Its structural properties contribute to effective interactions with protein partners, making it suitable for advancing research in targeted therapeutics and cellular modulation. -
PROTAC Linker
3-[Benzyl(methyl)amino]propanoic acid functions as a PROTAC linker, instrumental in the construction of PROTAC molecules that facilitate targeted protein degradation. This reagent enhances the therapeutic efficacy of PROTACs by enabling the selective removal of specific proteins within cellular environments. It is crucial for researchers developing novel approaches to study protein dynamics and therapeutic interventions in various disease states. -
PROTAC Linker
H2N-PEG2-CH2COOtBu hydrochloride is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates the conjugation of target proteins to E3 ligases, enabling efficient cellular degradation of specific proteins. This compound is essential for research applications focused on targeted protein degradation and the development of novel therapeutic strategies in various diseases. -
PROTAC Linker
m-PEG12-Br is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its primary mechanism involves facilitating the conjugation of ligands to E3 ubiquitin ligases, enabling targeted protein degradation. m-PEG12-Br enhances the solubility and bioavailability of PROTACs, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
2-(4-(2-Aminoethyl)piperazin-1-yl)ethan-1-ol serves as a linker in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the conjugation of target proteins for ubiquitin-mediated degradation. It is essential for synthesizing innovative PROTACs that can enhance the specificity and efficacy of targeted protein degradation therapies in various biological research applications. -
PROTAC Linkers
Hydroxy-PEG7-CH2-Boc is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the effective conjugation of target proteins and E3 ligases, enhancing the development of targeted protein degradation strategies. Its hydrophilic properties contribute to improved solubility and bioavailability, making it suitable for diverse research applications in drug discovery and pharmacological studies. -
PROTAC Linker
7-((Tert-butyldimethylsilyl)oxy)heptan-1-ol is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of targeted protein degradation complexes by linking ligands to E3 ligase receptors. Its application is essential in the development of novel therapeutic strategies for various diseases by enabling selective degradation of specific proteins. -
PROTAC Linker
tert-Butyl cis-4-(2-aminoethyl)cyclohexylcarbamate is a PROTAC linker utilized in the synthesis of PROTAC (Proteolysis-Targeting Chimeras) molecules. This compound enhances the development of targeted protein degradation systems, facilitating the selective removal of specific proteins from cells. It serves as a crucial component in research aimed at addressing various diseases by enabling the modulation of protein levels through controlled proteolysis. -
PROTAC Linker
N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5 is a PEG-based linker designed for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the assembly of PROTACs by linking the E3 ligase to target proteins, enhancing targeted protein degradation. Its stability and solubility in biological systems make it suitable for various research applications in drug discovery and cellular biology. -
PROTAC Linker
tert-Butyl (3-aminopropoxy)carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound enhances the specificity and efficacy of targeted protein degradation by providing a versatile connection between the ligand and the E3 ubiquitin ligase. Its application in chemical biology enables researchers to investigate protein functions and therapeutic interventions through the modulation of cellular protein levels. -
PROTAC Linker
Benzyl 2-cyanoacetate is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in linking target proteins to E3 ligases, enhancing targeted protein degradation. Its application is essential for researchers developing innovative therapeutics in cancer and other diseases by enabling the selective modulation of protein levels within cells. -
PROTAC Linker
(S)-tert-Butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate is a key PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins by linking ligands that recruit an E3 ligase to the target protein. Its application in PROTAC research aids in the development of novel therapeutics for various diseases by enabling precise modulation of protein levels. -
PROTAC Linker
3-(Piperidin-4-yl)propan-1-amine is a specialized PROTAC linker that facilitates the development of targeted protein degradation systems. This compound is essential for the synthesis of PROTACs, allowing researchers to create bifunctional molecules that induce degradation of specific proteins. Its structural features enhance binding affinity and stability, making it a valuable tool in drug discovery and development. -
PROTAC Linker
tert-Butyl 18-bromooctadecanoate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases, enabling targeted protein degradation. Its distinct structure allows for effective conjugation with various targeting moieties, making it a valuable tool in drug discovery and development focused on modulating protein levels in cellular contexts. -
PROTAC Linker
tert-Butyl ((3-aminocyclobutyl)methyl)carbamate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound aids in the selective degradation of target proteins, thereby advancing studies in protein homeostasis and therapeutic interventions. Its application in the development of PROTACs positions it as a crucial reagent in chemical biology and drug discovery research. -
PROTAC Linker
N,N'-Di-Boc-1,4-butanediamine functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the synthesis of PROTACs, enabling targeted protein degradation for various applications in chemical biology. Its structural properties contribute to the stability and efficiency of PROTAC conjugates in research studies. -
PROTAC Linker
tert-Butyltrimethylsilane-PEG2-NH2 is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to target proteins, enabling targeted protein modulation. Its application is instrumental in advancing research in targeted protein degradation and therapeutic discovery. -
PROTAC Linker
3-(Aminomethyl)cyclobutanecarboxylic acid hydrochloride acts as a PROTAC linker, facilitating the assembly of Proteolysis Targeting Chimeras (PROTACs). This compound enables the effective ubiquitination and subsequent degradation of target proteins by linking ligands to E3 ligases. Its use is critical in research focused on targeted protein degradation and therapeutic applications in various diseases, including cancer. -
PROTAC Linker
(S,R,S)-Ahpc-PEG6-azide is a click chemistry PROTAC linker that integrates an E3 ligase ligand and a PEG6 arm, facilitating the advancement of PROTAC research and discovery. The hydrophilic PEG spacer enhances solubility in aqueous environments, making it suitable for various biological applications. The presence of the azide functionality allows for efficient click chemistry reactions with alkyne, DBCO, or BCN molecules, thereby enabling versatile conjugation strategies in drug development. -
PROTAC Linker
Cyano-PEG4-cyano is a bifunctional PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a polyethylene glycol (PEG) spacer, which enhances solubility and biocompatibility. Cyano-PEG4-cyano serves as a crucial component in the development of targeted protein degradation strategies, enabling researchers to investigate cellular protein dynamics and therapeutic interventions in disease models. -
PROTAC Linker
7-Oxoheptanoic acid methyl ester serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficiency of targeted protein degradation by connecting an E3 ligase ligand to a targeting moiety. Its role in research applications includes investigating novel therapeutic strategies for diseases by promoting selective protein degradation. -
PROTAC Linker
5-((tert-Butyldimethylsilyl)oxy)pentanal is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of proteins by enabling the recruitment of E3 ligases, thus enhancing the efficacy of targeted protein degradation strategies. Its use in research applications allows for the advancement of therapeutic development in areas such as cancer and autoimmune diseases. -
PROTAC Linker
trans-3-Aminocyclobutanecarboxylic acid serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). By connecting target proteins with E3 ubiquitin ligases, it enhances the selective degradation of specific proteins. This compound is pivotal for research applications in targeted protein degradation and therapeutic development in various diseases. -
PROTAC Linker
tert-Butyl 1-(hydroxymethyl)-5-azaspiro[2.4]heptane-5-carboxylate serves as an effective PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the selective targeting and degradation of specific proteins, making it valuable for research in targeted protein degradation and therapeutic development. Its structure supports stable conjugation with target ligands, enhancing the efficacy of PROTAC strategies in cellular assays. -
PROTAC Linker
15-(tert-Butoxy)-15-oxopentadecanoic acid is a specialized PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enables the targeted degradation of specific proteins, enhancing the utility of PROTAC technology in drug discovery and therapeutic research. It is essential for the synthesis of effective PROTACs, allowing researchers to manipulate protein levels within cellular systems for various applications in cancer research and other diseases. -
PROTAC Linker
Benzyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate serves as a valuable PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables effective engagement and regulation of target proteins by harnessing the ubiquitin-proteasome system, making it instrumental in various biochemical studies focused on targeted protein degradation and therapeutic applications in drug discovery. -
PROTAC Linker
Boc-C-PEG2-I is a versatile linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the covalent attachment of protein ligands to E3 ubiquitin ligases, enabling targeted degradation of specific proteins within the cell. Its PEGylated structure enhances solubility and stability, making it suitable for various biochemical and cellular applications in drug discovery and molecular biology research. -
PROTAC Linker
Ethyleneglycolbis(monochloroacetate) serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). Its structure enables effective conjugation of target-specific ligands to E3 ligase recruiters, thereby promoting targeted protein degradation in cellular systems. This reagent is essential for researchers investigating the regulation of protein levels and the therapeutic potential of targeted protein modulation.
