Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
N,N'-bis-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of the target protein and an E3 ligase, enabling targeted protein degradation. Its fluorescent properties make it suitable for tracking and visualizing cellular activities, providing valuable insights in drug discovery and biological research. -
PROTAC Linker
Propargyl-PEG-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the covalent attachment of protein ligands and E3 ligase ligands, enhancing the efficiency of targeted protein degradation. Propargyl-PEG-acid is essential for researchers developing novel therapeutic strategies in cancer and other diseases through the modulation of protein levels. -
PROTAC Linkers
Fmoc-NMe-PEG4-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an N-hydroxysuccinimide (NHS) functionality, allowing for effective conjugation to target proteins via amine groups. Its use facilitates the development of targeted protein degradation strategies, making it valuable in drug discovery and development research. -
PROTAC Linkers
m-PEG2-phosphonic acid is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the construction of bifunctional molecules that can selectively induce degradation of target proteins via the ubiquitin-proteasome system. m-PEG2-phosphonic acid is essential for researchers focusing on targeted protein degradation and optimizing PROTAC development for therapeutic applications. -
PROTAC Linker
MS-PEG4-THP is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTAC (proteolysis-targeting chimera) compounds. This linker enhances the design and efficacy of PROTACs by facilitating the targeted degradation of specific proteins within the cell. Its structural properties support research applications in cellular signaling, protein homeostasis, and the development of novel therapeutic strategies for various diseases. -
PROTAC Linkers
Hydroxy-PEG16-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker features a hydroxy group that can facilitate conjugation to target proteins, enhancing the stability and solubility of the resultant PROTAC molecules. Hydroxy-PEG16-Boc is valuable for research applications aimed at developing targeted protein degradation strategies in various biological contexts. -
PROTAC Linker
Bromo-PEG2-THP is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that can selectively tag proteins for ubiquitin-mediated degradation, providing a novel approach to targeted protein modulation. Bromo-PEG2-THP is essential for researchers investigating targeted therapies and protein degradation pathways in various biological systems. -
PROTAC Linkers
THP-PEG10-THP is a PEG-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling the targeted degradation of specific proteins in cellular systems. THP-PEG10-THP is essential for researchers investigating protein regulation and therapeutic strategies for various diseases through targeted ubiquitination and proteasomal degradation. -
PROTAC Linkers
DSPE-PEG13-TFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of an E3 ligase recruiting module with a target protein ligand, promoting targeted protein degradation. Its application is crucial in advancing research focused on proteolysis and drug discovery, enabling the development of innovative therapeutic strategies. -
PROTAC Linker
Fluorescein-PEG3-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, facilitating targeted degradation of specific proteins. It is primarily utilized in chemical biology research to study protein function and interactions through targeted protein degradation methods. -
PROTAC Linkers
Methyl acetate-PEG1-methyl acetate is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of bifunctional molecules, enabling targeted protein degradation. Its unique structure enhances solubility and flexibility, making it suitable for diverse research applications in drug development and protein engineering. -
PROTAC Linker
OPSS-PEG8-COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the construction of bifunctional molecules that can selectively target and degrade proteins of interest via the ubiquitin-proteasome system. Its application is crucial for researchers investigating targeted protein degradation and developing novel therapeutic strategies in various diseases. -
PROTAC Linkers
Bromo-PEG1-NH2 hydrobromide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound enables the targeted degradation of specific proteins by facilitating the assembly of E3 ligase complexes and the desired target proteins. It is a valuable tool in drug discovery and the development of novel therapeutic strategies focused on protein modulation. -
PROTAC linker
Biotin-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies, enabling the selective degradation of specific proteins within cells. Its biotinylated structure enhances the efficiency of target protein recruitment, making it a valuable tool for researchers investigating protein function and degradation pathways. -
PROTAC Linkers
DBCO-PEG1-NH-Boc is a PEG-based linkerso designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a dibenzocyclooctyne (DBCO) functional group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules. This reagent is integral in developing targeted protein degradation strategies, facilitating the specific modulation of protein levels in cellular studies. -
PROTAC Linkers
Decaethylene glycol dodecyl ether is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile scaffold for linking target proteins and E3 ligases, enhancing the selective degradation of specific proteins in cellular models. Its unique structure provides improved solubility and stability, making it an essential tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linkers
3,4-Dibromo-Mal-PEG4-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its key mechanism involves facilitating the conjugation of target proteins to E3 ubiquitin ligases, thereby promoting targeted degradation. This compound is essential for researchers focusing on targeted protein degradation and related therapeutic development. -
PROTAC Linkers
Br-PEG3-C2-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the formation of linkers that connect a target protein to an E3 ligase, promoting targeted protein degradation. Its unique structure enables improved solubility and enhances the overall efficacy of PROTAC molecules in cellular applications and drug discovery research. -
PROTAC Linkers
Bromo-PEG5-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bromo group that enhances its reactivity, facilitating the conjugation of protein targets for targeted degradation. Its use in PROTAC development makes it valuable for research into protein regulation and therapeutic applications in various diseases. -
PROTAC Linkers
Hydroxy-PEG3-CH2-Boc is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimera) applications. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing target degradation through the ubiquitin-proteasome pathway. Its biocompatibility and tunable properties make it ideal for use in the development of novel therapeutic agents aimed at selective protein modulation in various biological research applications. -
PROTAC Linker
Boc-NH-PEG1-CH2COOH is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structure facilitates precise conjugation, enhancing the delivery and efficacy of target-specific degradation. This linker is particularly valuable in research applications aimed at studying protein degradation pathways and developing novel therapeutics. -
PROTAC Linkers
Biotin-PEG4-amino-t-Bu-DADPS-C3-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functional group and is suitable for click chemistry applications, specifically enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. It serves as a valuable tool for bioconjugation and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Biotin-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the targeted degradation of specific proteins through the recruitment of E3 ubiquitin ligases. It is valuable for researchers investigating protein turnover, cellular signaling pathways, and the development of novel therapeutic strategies in drug discovery. -
PROTAC Linker
Boc-piperazine-benzoic acid acts as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound can be utilized in the development of PROTACs that target specific proteins for degradation, including the androgen receptor (AR) degrader ARD-2128. Its implementation in research enables advanced studies in protein regulation and therapeutic applications in cancer treatment. -
PROTAC Linker
H2N-PEG2-CH2COOtBu is a polyethylene glycol (PEG) linker specifically designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of bifunctional molecules that promote targeted protein degradation, making it essential for research in drug development and cellular regulation studies. Its application in PROTAC technology allows for the selective modulation of protein levels, offering significant potential in the fields of cancer therapy and targeted therapeutics. -
PROTAC Linkers
Boc-NH-PEG6-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target binding moieties to E3 ligase ligands, promoting targeted protein degradation. It is particularly valuable in drug discovery and development, enabling researchers to explore novel therapeutic strategies through targeted modulation of protein levels. -
PROTAC Linker
4-Maleimidobutyric acid is a versatile alkyl chain-based PROTAC linker designed for the synthesis of protein-targeting chimeras. This compound facilitates the effective conjugation of E3 ligase ligands and target proteins, enhancing the efficacy of PROTAC-mediated degradation. Its application is crucial in drug discovery and development, particularly in medicinal chemistry aimed at targeted protein degradation strategies. -
PROTAC Linkers
Thiol-PEG4-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. Its terminal thiol group facilitates the conjugation of various ligands, enabling the effective formation of PROTACs that can induce targeted protein degradation. This linker is instrumental in research applications focusing on protein modulation and has potential implications in drug discovery and development. -
PROTAC Linkers
N-Mal-N-bis(PEG2-NHS ester) is a polyethylene glycol (PEG) based PROTAC linker designed to enable the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the desired protein, improving cellular uptake and solubility. Its utility in research applications includes the development of tailored PROTACs for targeted protein degradation studies and therapeutic interventions. -
PROTAC Linker
tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate serves as a PROTAC linker, facilitating the development of PROTAC molecules aimed at targeted protein degradation. Its unique structure enables efficient conjugation to target proteins, enhancing the specificity and efficacy of the resulting bifunctional degraders. This compound is instrumental in advancing research in proteomics and drug discovery, providing valuable insights into the modulation of protein levels within cellular systems. -
PROTAC Linker
3-(Methylamino)propan-1-ol is a PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound is essential for binding to the target protein and recruiting an E3 ligase, thus promoting targeted protein degradation. Its application is pivotal in the development of novel therapeutic strategies for a range of diseases by enabling targeted modulation of protein levels. -
PROTAC Linker
tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate functions as a PROTAC linker, playing a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins, thereby enhancing the potential for therapeutic interventions in various biological pathways. It serves as a valuable tool for researchers investigating targeted protein degradation mechanisms and the development of innovative treatments. -
PROTAC Linker
4-(1-Boc-4-piperidyl)phenylboronic acid pinacol ester serves as a versatile PROTAC linker. It enables the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating the targeted degradation of specific proteins. Its unique structural features provide effective conjugation capabilities, making it a valuable tool in drug discovery and targeted protein degradation research. -
PROTAC Linker
Monomethyl octanoate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential in the synthesis of bifunctional molecules that can selectively degrade target proteins, enhancing the study of protein function and dynamics. Its integral role in PROTAC design makes it a valuable tool for researchers investigating targeted protein degradation and therapeutic applications in drug discovery. -
PROTAC Linker
5-Iodopent-1-yne is a versatile PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases, enabling targeted degradation of specific proteins within cellular contexts. Its alkynyl functional group enhances click chemistry applications, making it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linker
6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid serves as a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for the optimization of protein degradation strategies and the targeted modulation of biological pathways. Its structural attributes enhance selectivity and efficacy in protein targeting, making it instrumental for research in targeted protein degradation and related therapeutic applications. -
PROTAC Linker
2-(Aminooxy)ethanol serves as a versatile PROTAC linker, facilitating the construction of PROTAC molecules designed for targeted protein degradation. It features a significant role in connecting ligands to E3 ubiquitin ligases, thereby enhancing the selective degradation of specific proteins within cellular contexts. This compound is pivotal in drug discovery and development, particularly for the targeted modulation of disease-related proteins. -
PROTAC Linker
3-Oxocyclobutane-1-carbonitrile is a versatile PROTAC linker that plays a critical role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted protein degradation by linking an E3 ligase ligand to a protein of interest, thereby enhancing the specificity and efficacy of therapeutic interventions. Its application in drug discovery makes it an essential reagent for researchers exploring novel therapeutic strategies in cellular regulation and targeted degradation. -
PROTAC Linker
Methyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride serves as a PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the targeted degradation of specific proteins through the recruitment of E3 ligases, making it a valuable tool for drug discovery and development. Its robust linkage properties support the design and optimization of innovative therapeutic strategies in chemical biology and pharmacology research. -
PROTAC Linker
Boc-C9-Br is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. This compound enhances the development of targeted protein degradation strategies in chemical biology and therapeutic research applications. -
PROTAC Linker
Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, enhancing their ubiquitination and subsequent degradation. Its application in PROTAC development supports targeted protein degradation studies and therapeutic exploration in various diseases, including cancer. -
PROTAC Linker
3-Chlorobicyclo[1.1.1]pentan-1-amine hydrochloride functions as a linker in the development of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the covalent attachment of targeted proteins, enhancing the specificity and efficacy of protein degradation strategies. It is valuable in biochemical research aimed at elucidating protein function and exploring novel therapeutic approaches in drug discovery. -
PROTAC Linker
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid serves as a versatile linker for the design and synthesis of PROTACs (proteolysis-targeting chimeras). Its structural properties facilitate the assembly of target protein degradation complexes, enhancing cellular specificity and efficacy. This compound is instrumental in furthering research in targeted protein degradation strategies, aiding the development of therapeutics for various diseases. -
PROTAC Linker
tert-Butyl (8-bromooctyl)carbamate functions as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). Its structural properties enhance the stability and efficacy of the resulting conjugates, promoting selective protein degradation. This compound is essential for researchers exploring targeted protein degradation pathways and advancing therapeutic strategies. -
PROTAC Linker
tert-Butyl (3-(methylamino)propyl)carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is crucial for connecting the Warhead and E3 ligase, enhancing the specificity and efficacy of targeted protein degradation. Its application in research allows for the investigation of cellular processes and therapeutic strategies through the selective modulation of protein levels. -
PROTAC Linker
cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid serves as a versatile PROTAC linker involved in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, thereby enabling targeted therapeutic strategies. Its structural properties make it suitable for various applications in drug discovery and development, particularly in the context of targeted protein modulation and degradation studies. -
PROTAC Linker
Methyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate is a specialized linker for proteolysis-targeting chimeras (PROTACs). It facilitates the development of targeted protein degradation strategies by connecting ligand components. This compound is essential for researchers investigating targeted therapies and protein regulation through PROTAC technology. -
PROTAC Linkers
BM-PEG3 is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the formation of bifunctional molecules that promote targeted degradation of proteins via the ubiquitin-proteasome system. This linker is essential for researchers focusing on the development of novel therapeutics that harness the power of targeted protein degradation for disease intervention. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (2-hydroxyethyl)carbamate serves as a PROTAC linker, facilitating the construction of PROTAC molecules for targeted protein degradation. This compound plays a crucial role in bridging target proteins with E3 ligases, enabling the development of novel therapeutics. Its structural properties support applications in drug discovery, particularly in studying selective protein modulation and degradation pathways. -
PROTAC Linker
tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of innovative therapeutic strategies by promoting targeted protein degradation. Its structural attributes enhance the stability and efficacy of PROTAC constructs, making it a valuable tool in chemical biology and drug discovery research.
