Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Boc-HyNic-PEG1-mal is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules that engage E3 ligases and target specific proteins for ubiquitination and degradation. It is suitable for applications in targeted protein degradation studies and therapeutic research, contributing to advancements in protein modulation strategies. -
PROTAC Linker
Acid-C2-PEG3-NHS ester is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins for enhanced selective degradation in cellular assays. Its properties make it an essential tool for researchers exploring targeted protein degradation and drug discovery applications. -
PROTAC Linker
Boc-NH-PEG4-C3-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins and E3 ligases, enabling targeted protein degradation. Its unique structure enhances solubility and stability, making it suitable for various biological applications in drug discovery and development. -
PROTAC Linker
1-(t-Boc-Aminooxy)-3-aminooxy-propane is an alkyl/ether-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This versatile compound facilitates the selective degradation of target proteins through the modulation of ubiquitin-proteasome pathways. Its unique properties make it ideal for research applications in targeted protein degradation, enabling advancements in drug development and therapeutic strategies. -
PROTAC Linkers
Methylamino-PEG3-acid is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the selective degradation of target proteins through the ubiquitin-proteasome system, enabling studies in protein modulation and targeted therapy. Methylamino-PEG3-acid is essential for researchers exploring the development of innovative therapeutic strategies in areas such as cancer and other protein misfolding diseases. -
PROTAC Linker
m-PEG3-Tos is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) applications. This compound enables the effective synthesis of targeted degrader molecules, facilitating the selective degradation of proteins within cells. Its innovative structure enhances solubility and promotes optimal biological activity, making it a valuable tool for researchers in drug discovery and chemical biology. -
PROTAC Linker
m-PEG5-Tos is a PEG-based PROTAC linker designed to facilitate targeted protein degradation. This compound serves as a critical building block in the synthesis of Silymarin, enhancing the specificity and efficacy of PROTAC molecules. Research applications include studies on protein modulation and the development of targeted therapies in various disease models. The unique structure of m-PEG5-Tos enables efficient conjugation with target proteins, promoting innovative approaches in chemical biology. -
PROTAC Linker
Ald-CH2-PEG3-CH2-Boc is a PEG- and alkyl/ether-based PROTAC linker designed to facilitate the construction of proteolysis-targeting chimeras (PROTACs). This linker plays a crucial role in synthesizing SGK3 kinase PROTAC degraders, enabling selective degradation of target proteins. Its unique structure enhances solubility and promotes effective engagement with target proteins for research applications in targeted protein degradation and mechanistic studies of cellular pathways. -
PROTAC Linkers
TCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a TCO (trans-cyclooctene) moiety, enabling it to participate in inverse electron demand Diels-Alder reactions with tetrazine-conjugated molecules. Its utility in click chemistry makes it a valuable tool for researchers aiming to develop innovative therapeutics targeting specific proteins for degradation. -
PROTAC Linker
Azido-PEG6-PFP ester is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. Its utility in click chemistry facilitates the development of targeted protein degradation strategies in various biological research applications. -
PROTAC linker
L-Azidohomoalanine is a versatile click chemistry reagent designed as an alkyl chain-based linker for PROTAC synthesis. It features an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, L-Azidohomoalanine can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. Its unique properties make it suitable for research applications involving targeted protein degradation and modular assembly of multifunctional biomolecules. -
PROTAC Linker
NH2-PEG5-C6-Cl is a PROTAC linker designed to facilitate the degradation of intracellular targets through targeted protein degradation pathways. This compound features a polyethylene glycol (PEG) moiety that enhances solubility and pharmacokinetic properties, making it suitable for the synthesis of novel PROTAC compounds. Its application in research enables studies on cellular control mechanisms and the development of therapeutic strategies aimed at modulating protein levels through autophagy. -
PROTAC Linkers
TCO-PEG24-NHS ester is a PEG-based linker designed for PROTAC synthesis, facilitating the creation of bifunctional molecules for targeted protein degradation. This compound features a TCO moiety, enabling it to engage in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing partners. It serves as a valuable tool for researchers exploring innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
Amino-PEG27-amine is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the assembly of bifunctional molecules that can promote target protein degradation via the ubiquitin-proteasome system. Its application in PROTAC development enables researchers to efficiently study protein function and modulation in various biological contexts. -
PROTAC linker
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it suitable for bioconjugation applications. It is essential for the development of PROTAC molecules that can selectively induce degradation of specific target proteins within cellular systems, thereby advancing research in targeted protein modulation and therapeutic intervention. -
PROTAC linker
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based linker that facilitates the synthesis of PROTACs by incorporating a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This linker allows for the precise modification of biomolecules, enhancing their stability and solubility. It is particularly useful in the development of targeted protein degradation strategies and other chemical biology applications involving conjugation techniques. -
PROTAC Linker
Aminooxy-PEG4-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound contains an aminooxy functional group that facilitates the covalent attachment of substrates, enhancing the specificity and efficiency of targeted protein degradation. It is a valuable tool for researchers investigating protein regulation and degradation pathways within cellular models and therapeutic applications. -
PROTAC linker
Propargyl-PEG2-N-bis(PEG2) is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing compounds. Its application in PROTAC development facilitates targeted protein degradation studies, expanding research in cellular regulation and therapeutic interventions. -
PROTAC Linker
Benzyl-PEG5-NHBoc is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can selectively target and degrade proteins via the ubiquitin-proteasome system. Its hydrophilic properties enhance the solubility and bioavailability of PROTACs, making it suitable for a range of applications in drug discovery and molecular biology research. -
PROTAC Linker
Benzyl-PEG3-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This chemical compound facilitates the formation of targeted protein degradation molecules, enhancing the selectivity and efficacy of therapeutic agents. Its unique structure allows for improved solubility and bioavailability, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Benzyl-PEG2-CH2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its flexible structure enables effective protein degradation by facilitating the binding of E3 ligases to target proteins. This compound is valuable in developing targeted protein degradation strategies for research in cancer, neurodegenerative diseases, and other therapeutic applications. -
PROTAC Linkers
Thiol-PEG4-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a thiol group that facilitates conjugation to various targeting moieties, enabling the efficient design of bifunctional molecules for targeted protein degradation. Thiol-PEG4-Boc is instrumental in advancing research in cellular signaling, cancer therapy, and other areas where selective protein modulation is essential. -
PROTAC Linkers
Boc-NH-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. Featuring an azide functional group, it is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) using alkyne-containing substrates or compounds with DBCO or BCN groups. This reagent is essential for the development of bifunctional molecules in targeted protein degradation research applications and facilitates the efficient assembly of PROTACs. -
PROTAC Linker
N-Benzyl-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic connection between the target protein and the E3 ligase. Its unique structure enhances cellular permeability and stability, making it suitable for applications in targeted protein degradation research. -
PROTAC Linkers
Methyltetrazine-PEG24-amine is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. This compound is critical for researchers developing novel therapeutic strategies that leverage the ubiquitin-proteasome system to selectively eliminate unwanted proteins. Its biocompatibility and versatility make it a valuable tool in drug discovery and development. -
PROTAC Linkers
DBCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. The compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its high level of biocompatibility and efficient conjugation properties make it suitable for various applications in chemical biology and therapeutic development. -
PROTAC Linkers
Tos-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent facilitates the conjugation of targeted proteins, enhancing the selective degradation of specific substrates via the ubiquitin-proteasome pathway. It is suitable for research applications in targeted protein degradation and drug discovery, enabling the development of innovative therapeutic strategies. -
PROTAC linker
Boc-NH-PEG9-azide is a PEG-based linker designed for usage in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for protein degradation studies and drug development applications. -
PROTAC Linker
Fmoc-PEG3-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating the development of targeted protein degradation strategies. It is particularly valuable for researchers investigating novel therapeutic pathways and mechanisms involving targeted protein modulation. -
PROTAC Linker
N-Ethyl-N-methylpropionamide-PEG1-Br functions as a PEG-based linker in PROTAC (proteolysis-targeting chimera) technology. This reagent facilitates the design and assembly of PROTAC molecules, enabling targeted degradation of selected proteins. Its unique properties support the development of innovative therapeutics in drug discovery and various fields of biological research. -
PROTAC Linkers
Tos-PEG7-OH is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases for targeted protein degradation, making it a valuable tool in drug discovery and development. Its unique structure enhances solubility and reactivity, supporting efficient construction of bifunctional molecules that modulate biological pathways. Ideal for researchers investigating targeted therapies and proteasome-mediated degradation mechanisms. -
PROTAC Linkers
Tos-PEG9-Tos is a PEG-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates efficient conjugation of target proteins and E3 ligases, promoting targeted protein degradation. Its unique structure enhances solubility and stability, making it valuable for research applications in drug discovery and therapeutic development related to targeted protein modulation. -
PROTAC Linkers
N-Desthiobiotin-N-bis(PEG4-NHS ester) is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the effective conjugation of target proteins with E3 ligases, enhancing degradation pathways in cellular systems. This compound is valuable for research applications involving targeted protein degradation and the study of proteostasis. -
PROTAC Linker
Azido-PEG3-Ala-Boc functions as a PEG-based linker specifically designed for PROTAC synthesis. This compound features an azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG3-Ala-Boc can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it suitable for diverse applications in targeted protein degradation research. -
PROTAC Linker
m-PEG5-phosphonic acid is a polyethylene glycol (PEG)-derived linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound effectively facilitates the conjugation of ligand and target moieties, enabling the selective degradation of specific proteins within cells. m-PEG5-phosphonic acid is instrumental in the development of novel therapeutic strategies aimed at modulating protein levels for various research applications in cancer and other diseases. -
PROTAC linker
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, which are essential for conjugating azide-containing molecules. Its properties make it valuable for studies in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Methyl-PEG3-Ald is a polyethylene glycol (PEG) based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It serves as a molecular scaffold to facilitate targeted protein degradation by linking an E3 ligase recruiter to a target protein ligand. This compound enhances the selectivity and efficacy of PROTACs, making it a valuable tool for studying protein regulation and degradation in various biological contexts. -
PROTAC Linker
THP-PEG5-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTAC molecules. This linker facilitates the development of targeted protein degradation systems by connecting a ligand for a target protein to an E3 ligase ligand. Its versatility supports applications in drug discovery and the investigation of cellular processes involving protein degradation. -
PROTAC Linker
Mal-PEG2-PFP ester is a bifunctional linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This alkyl/ether-based compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins of interest through the ubiquitin-proteasome pathway. Its tunable spacer length and functional groups enhance the efficiency and specificity of PROTAC development, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
N-Me-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC synthesis. This compound features an alkyne functional group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the development of PROTACs facilitates targeted protein degradation, making it a valuable tool for researchers exploring therapeutic strategies in drug discovery and cellular biology. -
PROTAC Linkers
Bis-isopropyl-PEG1 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds. This linker facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of proteins of interest. Its application in PROTAC development supports a variety of research areas, including targeted protein degradation and drug discovery. -
PROTAC Linker
Fmoc-Val-Phe-Boc is a PROTAC linker utilized in targeted protein degradation applications. This compound acts as a maleimide-GGFG peptide linker, facilitating the efficient synthesis of bifunctional molecules. Key research applications include the development of PROTACs and other therapeutic agents, such as Deruxtecan, for precision oncology and related fields. -
PROTAC Linker
S-acetyl-PEG4-amine is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and biological stability of PROTACs, making it suitable for drug development studies aimed at targeted protein degradation. Its structure allows for efficient conjugation to target proteins and E3 ligases, enabling researchers to investigate novel therapeutic strategies in various disease models. -
PROTAC Linker
S-Acetyl-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways via targeted ubiquitination. This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing partners. Additionally, S-Acetyl-PEG3-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-reactive molecules such as DBCO or BCN. Its applications in chemical biology are crucial for the development of innovative therapeutic strategies. -
PROTAC Linkers
THP-CH3-ethyl propionate is an alkyl ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that selectively degrade target proteins through the ubiquitin-proteasome pathway. It is suitable for applications in targeted protein degradation research and the development of novel therapeutic strategies. -
PROTAC Linkers
F-PEG2-COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted degradation pathways. Its use is instrumental in drug discovery research, particularly in studies focused on the modulation of protein levels and elucidating protein function through targeted degradation strategies. -
PROTAC Linker
Thiol-PEG3-phosphonic acid serves as a PEG-based linker specifically designed for the formation of PROTAC (proteolysis-targeting chimeras). This compound facilitates the connection between target proteins and E3 ligases, promoting targeted protein degradation. It is instrumental in the development of therapeutic agents that harness targeted proteolytic mechanisms, thereby advancing research in drug discovery and protein regulation studies. -
PROTAC Linker
Bis-Mal-Lysine-PEG4-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound allows for the conjugation of E3 ligase recruiters to target proteins, facilitating the targeted degradation of specific proteins via the ubiquitin-proteasome system. It is a valuable tool for researchers investigating protein function and cellular pathways, as well as developing novel therapeutic approaches. -
PROTAC Linkers
THP-PEG1-THP is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates the conjugation of target proteins to E3 ligases, enhancing the degradation of specific proteins via the ubiquitin-proteasome pathway. THP-PEG1-THP is essential for researchers developing novel therapeutic strategies that involve targeted protein degradation. -
PROTAC Linker
Biotin-PEG4-allyl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of targeting moieties with E3 ligase recruiters, thereby promoting targeted protein degradation. Its biotin component enables efficient immobilization and enrichment of target proteins, making it a valuable tool in chemical biology and drug discovery research applications.
