Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for bioconjugation and drug development applications. -
PROTAC Linkers
Boc-NH-PEG8-propargyl is a PEG-based linker designed for the synthesis of PROTACs, primarily functioning as a key component in targeted protein degradation. This compound features an alkyne group that enables its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing molecules. Its utility makes it a valuable tool in medicinal chemistry, particularly for enhancing the specificity and efficiency of PROTAC design and development. -
PROTAC Linker
Boc-Aminooxy-PEG3-acid is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs, enabling the targeted degradation of specific proteins within cellular systems. Its unique structure enhances solubility and stability, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linkers
(+) -Biotin-PEG6-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases and targets specific proteins for degradation, thereby enabling the study of protein function and regulation in various biological contexts. Its hydrazide moiety allows for selective conjugation, enhancing the versatility of PROTAC development in chemical biology research. -
PROTAC Linkers
COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PCC16 chloride, enabling the selective modulation of protein targets in cellular systems. Its unique structure provides versatility in the development of bifunctional molecules for the research of protein-protein interactions and therapeutic agents. -
PROTAC Linker
Azido-PEG1-CH2CO2-NHS is an alkyl/ether-based PROTAC linker that facilitates the synthesis of PROTAC molecules. This click chemistry reagent features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it valuable for advanced chemical biology applications. Its utility in constructing targeted protein degradation systems enhances its relevance in molecular biology research. -
PROTAC Linker
S-acetyl-PEG6-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of bifunctional molecules that can selectively degrade target proteins via the ubiquitin-proteasome system. Its application is critical in drug discovery and therapeutic research aimed at targeting hard-to-drug proteins. -
PROTAC Linker
Dimethylamino-PEG2-C2-NH2 is a polyethylene glycol (PEG)-derived linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the connection between target proteins and E3 ubiquitin ligases, promoting ubiquitination and subsequent degradation of specific proteins. Its application is crucial in drug discovery and development, particularly in targeted protein degradation research. -
PROTAC Linker
Bis-PEG11-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins and E3 ligases, thereby enabling targeted protein degradation. Its application in research aids in the exploration of therapeutic strategies involving protein modulation and degradation pathways. Bis-PEG11-acid contributes significantly to the development of innovative PROTAC-based therapeutics. -
PROTAC Linker
Boc-NH-PEG6-propargyl is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its versatility in linker design makes it suitable for applications in drug discovery and development, particularly in the field of targeted protein degradation. -
PROTAC Linker
Boc-aminooxy-PEG4-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an alkyne group that enables its application in click chemistry, specifically permitting copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its functional properties make it an essential tool for researchers in drug development and biotechnology applications, particularly in the engineering of bifunctional small molecules. -
PROTAC Linker
Aniline-piperazine-C3-NH-Boc is a PROTAC linker designed for the synthesis of targeted protein degradation molecules. It facilitates the construction of conjugates such as Pomalidomide-C3-adavosertib and AZD1775, a Wee1 inhibitor. This compound is valuable for researchers investigating the mechanisms of protein regulation and degradation in various biological contexts. Its application in PROTAC technology enables innovative approaches to therapeutic development by enhancing targeted protein destruction. -
PROTAC Linkers
m-PEG9-t-Butyl ester is a polyethylene glycol (PEG) based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the development of bifunctional molecules that induce proteasome-mediated degradation of target proteins. Its structure provides favorable solubility and biocompatibility, making it suitable for applications in targeted protein degradation research and drug discovery. -
PROTAC linker
N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties, making it useful for selective protein degradation studies and related applications in chemical biology. -
PROTAC Linkers
PEG2-bis(phosphonic acid diethyl ester) serves as a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the effective engagement of target proteins for ubiquitination and subsequent degradation. This compound is essential in the development of targeted protein degradation strategies, contributing to advancements in cancer therapy and other areas of biomedical research. -
PROTAC Linkers
t-Boc-Aminooxy-PEG8-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a t-Boc-protected aminooxy group, facilitating the conjugation of E3 ligase ligands to target proteins. This compound plays a crucial role in enhancing the degradation of specific proteins, making it valuable for drug discovery and the study of protein modulation in cellular processes. -
PROTAC Linkers
SPDP-PEG4-acid is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by linking a target protein to an E3 ligase, enhancing the efficacy of PROTAC-based therapeutic strategies. It is a valuable tool in chemical biology for developing novel approaches in targeted therapy and studying protein interactions. -
PROTAC Linker
m-PEG7-CH2-OH is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligand-receptor pairs, enhancing the degradation of specific target proteins via the ubiquitin-proteasome system. It is valuable in biochemical research aimed at developing targeted therapeutics and investigating protein functionality. -
PROTAC Linker
Hydroxy-PEG4-CH2COOH sodium salt is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis targeting chimera) molecules. Its hydroxyl group enhances solubility and protein interaction, facilitating the targeted degradation of specific proteins in cellular systems. This reagent is essential for researchers developing innovative PROTAC therapies in applications including cancer treatment and protein regulation studies. -
PROTAC Linkers
Acryloyl-PEG4-OH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enabling targeted protein degradation. Its versatile application in PROTAC development makes it a valuable tool for research in protein regulation and therapeutic interventions. -
PROTAC Linker
Boc-PEG4-sulfonic acid is a PEG-based linker designed for use in PROTAC synthesis. It enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation research. This compound is instrumental in the development of innovative therapeutic strategies by enabling the selective modulation of protein levels within cellular systems. -
PROTAC Linker
Benzyl-PEG8-Ots is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the precise conjugation of a target protein to an E3 ligase, promoting targeted protein degradation. It plays a crucial role in advancing research in protein modulation and therapeutic development, particularly in studies focusing on cancer and other diseases where protein homeostasis is disrupted. -
PROTAC Linker
Azido-PEG3-Sulfone-PEG4-Boc is a PEG-derived linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that enables click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing partners. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatility makes Azido-PEG3-Sulfone-PEG4-Boc a valuable tool for studies in targeted protein degradation and other applications in chemical biology. -
PROTAC Linkers
Propargyl-PEG12-amine is a PEG-based linker designed for use in the synthesis of PROTACs. It features an alkyne functional group, allowing it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing partners. This compound is instrumental in facilitating the development of targeted protein degradation strategies, enhancing research in therapeutic interventions and cellular regulation. -
PROTAC Linkers
BnO-PEG1-CH2COOH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a carboxylic acid moiety, facilitating conjugation to target proteins and small molecules. It plays a crucial role in the development of bifunctional degrader molecules, enabling selective degradation of target proteins in various cellular contexts. This linker can significantly advance research in targeted protein degradation and drug development. -
PROTAC Linker
4-Hydroxy-1-piperidinepropanamide is a versatile PROTAC linker utilized in the development of PROTAC-based degraders, specifically for DDR1 degradation. This compound facilitates the targeted protein degradation pathway by connecting E3 ubiquitin ligases to specific protein targets. It is essential for researchers focusing on the modulation of protein levels through targeted degradation strategies in various biological studies. -
PROTAC linker
N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a PEG-based linker designed for use in the synthesis of PROTACs through a targeted compound degradation mechanism. This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient conjugation with azide-containing molecules. N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is instrumental in the creation of innovative therapeutic agents and is applicable in drug discovery research. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based linker designed for use in PROTAC (proteolysis targeting chimeras) synthesis. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biological activity in forming stable linkages facilitates targeted proteolysis research applications, making it a valuable tool for molecular biology and drug development studies. -
PROTAC Linkers
Boc-N-Amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]nonyne (BCN) groups, making it a versatile tool for chemical research and development in targeted protein degradation studies. -
PROTAC Linker
NH-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and stability of PROTACs, facilitating targeted protein degradation. Its unique structure allows for effective conjugation to ligands and proteins, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linkers
Pyrene azide 3 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it versatile for targeted protein degradation applications in chemical biology research. -
PROTAC Linker
N-(Boc-PEG4)-NH-PEG4-NH-Boc is a polyethylene glycol (PEG)-based linker optimized for the development of PROTACs (Proteolysis Targeting Chimeras). This compound serves as a valuable tool in the synthesis of bi-functional molecules intended for targeted protein degradation. It enables the efficient conjugation of various functional moieties, facilitating research in targeted therapies and the modulation of protein levels in cellular systems. -
PROTAC linker
Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation studies and drug discovery research. -
PROTAC Linker
Boc-NHCH2CH2-PEG1-azide is a PEG-based linker specifically designed for use in synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies in chemical research. -
PROTAC Linker
S-acetyl-PEG4-NHBoc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, effectively promoting targeted degradation. S-acetyl-PEG4-NHBoc is particularly valuable in research applications focused on protein regulation and therapeutic development through targeted protein degradation strategies. -
PROTAC Linkers
Boc-Aminooxy-PEG3-thiol is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It contains an aminooxy group that facilitates the formation of covalent bonds with targeted proteins, enabling targeted degradation through the ubiquitin-proteasome pathway. This compound is essential for researchers focusing on novel therapeutic strategies involving protein modulation and selective degradation in cellular studies. -
PROTAC Linker
N,N'-DME-N,N'-Bis-PEG2-acid is a PEG-based linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the selective degradation of target proteins by promoting ubiquitination and subsequent proteasomal degradation. Its application extends to various fields of research focused on targeted protein degradation, offering a valuable tool for studying protein function and developing therapeutic strategies. -
PROTAC Linker
Benzyl-PEG1-propanol serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by providing a flexible and hydrophilic connection that enhances solubility and biocompatibility. Its key role in the development of targeted protein degradation strategies makes it a valuable tool for chemical biology research, particularly in studies related to protein modulation and therapeutic development. -
PROTAC Linkers
Benzyl-PEG6-THP is a polyethylene glycol (PEG) based linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing flexibility and hydrophilicity, essential for optimizing target protein degradation. Its structure allows efficient conjugation with various protein ligands, enabling researchers to explore targeted protein modulation in cellular studies. -
PROTAC Linker
m-PEG10-Tos is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that promote targeted degradation of specific proteins via the ubiquitin-proteasome system. Its unique PEGylation properties enhance solubility and optimize pharmacokinetic profiles, making it a valuable tool for researchers in drug discovery and development. -
PROTAC Linker
Azido-PEG3-CH2CO2Me is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules. This versatility allows Azido-PEG3-CH2CO2Me to facilitate the formation of complex biomolecular conjugates, making it a valuable tool in targeted protein degradation research and various bioconjugation applications. -
PROTAC Linker
Chloroacetamido-C-PEG3-C3-NHBoc is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. It plays a crucial role in the development of novel therapeutics and is widely used in chemical biology and drug discovery applications. -
PROTAC Linkers
Benzyl-PEG6-amine is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking target ligands to E3 ligase recruiters. Its unique chemical structure allows for improved solubility and stability, making it an essential reagent in chemical biology and therapeutic research focused on targeted protein degradation. -
PROTAC Linkers
PEG3-bis(phosphonic acid) serves as a PEG-based linker in the development of PROTACs (Proteolysis Targeting Chimeras). Its structure facilitates the conjugation of target proteins to E3 ubiquitin ligases, thereby promoting targeted protein degradation. This compound is essential in research applications focused on therapeutic interventions via the modulation of protein levels within cells. -
PROTAC Linkers
DBCO-NHCO-PEG13-NHS ester is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the efficient formation of covalent linkages. Its application in PROTAC development supports targeted protein degradation studies, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Benzyl-PEG2-ethanol is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound enhances the solubility and stability of PROTAC molecules, facilitating efficient target protein degradation. Its application in chemical biology allows for the development of novel therapeutic agents that exploit the ubiquitin-proteasome system for targeted protein modulation. -
PROTAC Linker
Boc-NH-PEG6-azide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Boc-NH-PEG6-azide is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with constructs containing DBCO or BCN groups. Its applications are pivotal in the development of targeted protein degradation strategies. -
PROTAC Linker
Tos-PEG12-Tos is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and efficacy of PROTAC molecules, facilitating targeted protein degradation. Its unique structure allows for flexible and tunable linkages, making it suitable for a range of biological applications in drug development and research. -
PROTAC Linkers
Acid-PEG13-NHS ester is a PEGylated linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its extended polyethylene glycol (PEG) chain enhances solubility and stability, making it suitable for various biological applications in drug development and protein engineering. -
PROTAC linker
N-(Azido-PEG3)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This compound functions as a click chemistry reagent, featuring an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. These properties make it a valuable tool in chemical biology and drug discovery research.
