Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
m-PEG6-thiol is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the assembly of PROTACs by providing solubility and stability, enhancing target protein degradation. Its primary applications include drug discovery and development within targeted protein degradation research. -
PROTAC Linker
m-PEG8-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective conjugation of target proteins and E3 ligases, thereby enhancing the specificity and efficacy of targeted protein degradation. Its application is crucial in cancer research and drug discovery, enabling the development of novel therapeutics aimed at selectively degrading undesirable proteins in various biological contexts. -
PROTAC Linker
Bromo-PEG6-alcohol is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the development of novel protein degraders by enabling the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. Its utility in chemical biology and drug discovery makes it a valuable tool for researchers focused on targeted protein modulation and therapeutic interventions. -
PROTAC Linker
Mal-amido-PEG12-NHS ester is a PEGylated linker specifically designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of various ligands to E3 ubiquitin ligases, thereby enabling targeted degradation of specific proteins within cells. Key applications include studies of protein regulation and degradation mechanisms, as well as development of novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
Boc-aminoxy-PEG4-acid is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (Proteolysis Targeting Chimera) systems. It facilitates the conjugation of E3 ligase ligands and target proteins, thereby enhancing the efficiency of targeted protein degradation. This versatile linker is crucial for researchers developing PROTAC-based therapeutics and studying the principles of targeted protein modulation. Its PEG structure contributes to increased solubility and improved pharmacokinetic properties in biological applications. -
PROTAC Linker
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. Featuring a bicyclo[6.1.0]nonyne (BCN) group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its robust click chemistry properties make it suitable for applications in protein degradation research and therapeutic development. -
PROTAC Linkers
TCO-PEG8-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted degradation of proteins thought unsuitable for classical small-molecule approaches. It is a valuable tool for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
Biotin-PEG3-Mal is a biotin-conjugated polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ubiquitin ligases to the target proteins of interest. With its biotin moiety, Biotin-PEG3-Mal enables efficient capture and purification of PROTAC compounds, making it a valuable tool for drug discovery and cellular investigations into protein regulation. -
PROTAC Linker
Propargyl-PEG9-amine is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, enabling selective conjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG9-amine enhances the bioconjugation process, facilitating the development of targeted protein degradation tools for various biological research applications. -
PROTAC Linkers
m-PEG4-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligase, enabling targeted protein degradation. m-PEG4-SH is crucial for researchers seeking to develop novel PROTACs for applications in drug discovery and cellular protein regulation studies. -
PROTAC Linker
Mal-PEG2-NH2 TFA is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a versatile approach for enhancing the solubility and pharmacokinetic properties of PROTACs, facilitating targeted protein degradation. Mal-PEG2-NH2 TFA is essential for researchers aiming to develop selective degraders for therapeutic applications in diverse biological systems. -
PROTAC Linker
Fmoc-amino-PEG5-acid is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a fluoromethoxycarbonyl (Fmoc) protecting group, facilitating the incorporation of amino acids into the PROTAC design. Its PEG linker enhances solubility and promotes cellular uptake, making it valuable for research applications focused on targeted protein degradation and therapeutic development. -
PROTAC Linkers
Amino-PEG2-CH2CH2-SH hydrochloride is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the development of bifunctional molecules, enabling targeted protein degradation with precision. Its biocompatible structure enhances solubility and stability, making it suitable for a variety of applications in chemical biology and drug discovery, particularly in the creation of novel therapies for previously intractable targets. -
PROTAC Linker
Dde Biotin-PEG4-alkyne is a PEG-based PROTAC linker featuring an alkyne group, facilitating the synthesis of PROTACs. This compound serves as a click chemistry reagent, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in the design of bifunctional molecules allows for enhanced targeted degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linker
Amino-PEG5-Boc is a polyethylene glycol (PEG) linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the effective conjugation of target proteins with E3 ligases, enhancing the targeted degradation of specific proteins within cellular systems. The utilization of Amino-PEG5-Boc in research applications allows for improved study of protein homeostasis and therapeutic interventions in various diseases. -
PROTAC Linker
DBCO-PEG4-Desthiobiotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a DBCO moiety that facilitates efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is essential for developing targeted protein degradation tools, enabling researchers to investigate protein function and cellular pathways through controlled protein turnover. -
PROTAC Linkers
Boc-NH-PEG8-C2-Br is a PEGylated PROTAC linker designed to facilitate the development of targeted protein degradation strategies. This compound enhances the solubility and efficacy of PROTAC molecules while promoting the selective degradation of target proteins through the ubiquitin-proteasome pathway. Its application spans various research efforts aimed at elucidating cellular mechanisms and therapeutic approaches in oncology and other disease models. -
PROTAC Linker
Azide-PEG12-alcohol serves as a PEG-based linker for the development of PROTACs, facilitating targeted protein degradation through a well-defined chemistry. This compound contains an azide functionality, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules. Additionally, Azide-PEG12-alcohol can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified substrates, making it an invaluable tool for advancing chemical biology and therapeutic research. -
PROTAC Linker
8-Boc-2,8-Diazaspiro[4.5]decane is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound provides suitable spacer functionality, facilitating the conjugation of E3 ligase recruiters to target proteins, thereby enhancing selective degradation mechanisms. It is instrumental in advancing research applications in targeted protein degradation and drug discovery efforts. -
PROTAC Linker
tert-Butyl 4-(bromomethyl)benzylcarbamate serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation molecules. This compound is instrumental in constructing bifunctional molecules that recruit E3 ligases to specific substrates, promoting ubiquitination and subsequent proteasomal degradation. Its application is crucial for researchers investigating the modulation of protein levels for therapeutic purposes in various diseases. -
PROTAC Linker
Ethyl hydroxyacetate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis targeting chimeras (PROTACs). This compound enhances cellular degradation of specific proteins by connecting E3 ligases to target proteins, thereby promoting targeted protein degradation pathways. Its role is critical in advancing research in targeted therapies and protein modulation studies. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.5]nonan-7-yl}carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound's structural properties allow for effective engagement with target proteins, promoting ubiquitylation and degradation. It is instrumental in research focused on targeted protein degradation and the design of novel therapeutic agents. -
PROTAC Linker
tert-Butyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate serves as a versatile PROTAC linker that facilitates the design and synthesis of targeted protein degraders. This compound enhances the stability and activity of PROTACs by providing a robust covalent attachment point. Its unique structure contributes to improved cellular permeability and selectivity, making it a valuable tool in the development of innovative therapies for the modulation of protein targets in cancer and other diseases. This reagent is suitable for researchers working in drug discovery and development focusing on protein degradation pathways. -
PROTAC Linker
Sodium 5-hydroxypentanoate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the effective recruitment of E3 ligases to target proteins, thereby promoting their degradation via the ubiquitin-proteasome system. This compound is essential for research in targeted protein degradation, enabling investigations into protein function and regulation. -
PROTAC Linker
2-(4-Bromobutyl)-1,3-dioxolane is a potent PROTAC linker, facilitating targeted protein degradation through the development of bifunctional molecules. This compound is essential in synthesizing PROTACs, which function by harnessing the cellular ubiquitin-proteasome system to selectively degrade specific protein targets. Its unique structure enhances the efficiency of protein recruitment and degradation, making it valuable for research in targeted therapies and drug discovery. -
PROTAC Linker
3-(1-(Tert-butoxycarbonyl)azetidin-3-yl)cyclobutane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables targeted degradation of specific proteins, thereby advancing research in therapeutic strategies for diseases driven by dysfunctional proteins. Its structural properties support the efficient formation of ligand-linker conjugates, enhancing the development of innovative pharmacological agents. -
PROTAC Linker
1,3-Propanedithiol serves as a versatile PROTAC linker facilitating the synthesis of proteolysis-targeting chimera (PROTAC) molecules. This compound supports the development of targeted protein degradation strategies by providing a stable and flexible connection between the ligand and E3 ligase. Its unique properties enhance the efficiency and specificity of PROTAC formulations in various research applications related to cellular regulation, targeted therapy, and drug discovery. -
PROTAC Linker
1,4-Bis(2-bromoethoxy)benzene serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. Its structure promotes effective conjugation with warheads and E3 ligase recruiters, enabling efficient degradation of specific target proteins. This compound is essential for researchers aiming to explore novel therapeutic avenues in cancer and other diseases through targeted degradation strategies. -
PROTAC Linker
Hydroxy-PEG2-acid is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of PROTACs by connecting target proteins and E3 ligases, thereby promoting targeted degradation of specific proteins within cellular systems. Hydroxy-PEG2-acid is instrumental in advancing research in targeted protein degradation, offering potential therapeutic strategies in various diseases. -
PROTAC Linker
4-BocNH-Bicyclo[2.2.2]octane-COOH is a synthetic linker specifically designed for the development of PROTAC (proteolysis targeting chimeras) molecules. It facilitates the covalent attachment of target protein ligands with E3 ligase recognition elements, promoting targeted protein degradation. This compound is instrumental in chemical biology research, particularly in studies exploring targeted therapy and protein modulation. -
PROTAC Linker
Boc-10-Aminodecanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs) and other conjugation applications. This compound features an alkane chain with a terminal carboxylic acid and Boc-protected amino groups, facilitating efficient formation of stable amide bonds when reacted with primary amines in the presence of coupling agents such as EDC or HATU. The Boc group can be deprotected under mild acidic conditions to yield the free amine, enabling further functionalization and applications in targeted protein degradation research. -
PROTAC Linker
2-(1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidin-4-yl)acetic acid functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the synthesis of bifunctional molecules that can effectively harness the ubiquitin-proteasome system for targeted protein degradation. Its structure allows for tailored interactions in various biochemical applications, making it crucial for research in drug discovery and cellular biology. -
PROTAC Linker
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins through the ubiquitin-proteasome system, making it invaluable for research in targeted protein degradation and drug discovery. Its structural properties contribute to effective binding and functionality in the design of novel therapeutic agents. -
PROTAC Linker
4-(Methoxycarbonyl)cyclohexane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation compounds. Its unique structural properties enhance the stability and efficacy of PROTACs, enabling precise modulation of protein levels within cellular systems. This reagent is instrumental in research focused on targeted therapies and the study of protein function and regulation. -
PROTAC Linker
1,8-Dibromooctane serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTACs by providing a suitable connection between the targeting moiety and the E3 ligase recruiter. Its versatility makes it valuable in drug discovery and development, particularly in studies aimed at targeted protein degradation. -
PROTAC Linker
1,5-Diiodopentane is a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure enhances the efficiency of target protein degradation by providing optimal linkages between E3 ligases and the desired substrates. This compound is essential for researchers focusing on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a versatile PROTAC linker utilized in the synthesis of targeted protein degradation compounds. This reagent facilitates the development of PROTAC SOS1 degrader-8, contributing to studies focused on targeted therapy and protein regulation. Its unique structural properties enhance the specificity and effectiveness of protein degradation applications in chemical biology research. -
PROTAC Linker
1,7-Dibromoheptane is a versatile PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in the synthesis of bifunctional molecules, enabling targeted protein degradation for various research applications. Its structural properties allow for optimal interaction with E3 ligases and target proteins, making it an essential tool for advancing studies in targeted therapy and drug development. -
PROTAC Linker
Boc-Azetidine-C2-NH2 is a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its unique structure facilitates the formation of covalent bonds essential for targeted protein degradation. This compound is instrumental in advancing drug discovery and optimizing therapeutic modalities by enabling researchers to effectively manipulate protein levels in cellular models. -
PROTAC Linker
1-(Boc)-3-Fluoropiperidine-4-carboxylic acid acts as a key PROTAC linker in the development and synthesis of proteolysis-targeting chimeras (PROTACs). Its structural features enable efficient conjugation to protein ligands and E3 ligase moieties, facilitating targeted protein degradation. This compound is essential for advancing research in targeted therapies and cellular research applications. -
PROTAC Linkers
Boc-NH-O-C1-NHS ester is a versatile alkyl/ether-based linker specifically designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of proteins of interest. Its application in PROTAC development aids in research focusing on targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate functions as a PROTAC linker with a critical role in the design and synthesis of PROTAC molecules. This compound facilitates targeted protein degradation by linking degraders to specific protein targets, thereby enhancing the specificity and efficacy of the PROTACs in biological research. It serves as an important tool for studies in drug development and cellular signaling pathways. -
PROTAC Linker
MeOAc-PEG2-acid is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, making it an important component in the development of targeted protein degradation strategies. Its application in chemical research supports investigations into protein regulation and therapeutic interventions. -
PROTAC Linker
Boc-2-methylamino-ethylcarbamate hydrochloride is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound plays a crucial role in the synthesis of PROTACs, which are designed to selectively degrade target proteins through the ubiquitin-proteasome pathway. Its application in chemical biology research aids in the exploration of targeted protein degradation mechanisms and therapeutic development strategies. -
PROTAC Linker
tert-Butyl 2-oxo-6-azaspiro[3.4]octane-6-carboxylate serves as a crucial PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the specificity and efficacy of targeted protein degradation, making it an invaluable tool in drug discovery and cellular biology research. Its unique spirocyclic structure contributes to improved linker flexibility and optimal binding properties, thereby advancing the study of protein regulation mechanisms. -
PROTAC Linker
8-Boc-2,8-Diazaspiro[4.5]decane hydrochloride is a versatile PROTAC linker utilized in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of heterobifunctional molecules that engage target proteins for selective degradation through the ubiquitin-proteasome system. Its application is critical in drug discovery, particularly in the search for new therapeutic modalities that can modulate protein levels in a precise manner. -
PROTAC Linker
Undec-10-yn-1-ol serves as a PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficiency of targeted protein degradation by linking E3 ligases to specific proteins of interest. Its application is pivotal in advancing research in cellular signaling, protein turnover, and therapeutic development. -
PROTAC Linker
2-Propargyl-(trans)-4-cyclohexanediamine hydrochloride is a PROTAC linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted degradation of specific proteins by coupling ligand-binding domains of E3 ligases with protein ligands. Its efficacy makes it a valuable tool in the development of innovative therapeutic strategies for various diseases, including cancer. -
PROTAC Linker
Cis-5-Amino-2-Boc-hexahydro-cyclopenta[c]pyrrole serves as a PROTAC linker, playing a pivotal role in the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates targeted degradation of specific proteins, enabling researchers to investigate protein function and unravel complex biological pathways. Its application enhances the development of novel therapeutic strategies in drug discovery and biological research. -
PROTAC Linker
3-Hydroxybicyclo[1.1.1]pentane-1-carboxylic acid serves as a versatile PROTAC linker, facilitating the design and synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances target specificity and binding efficiency in cellular environments, making it valuable for degrading specific proteins. Its applications extend to the field of targeted protein degradation research, aiding the development of therapies for various diseases.
