Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets the STIM-1, NFATc3, and MAPK pathways. It effectively scavenges free radicals and exhibits a specific inhibitory effect on oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Through upregulation of miR-185, Rhamnocitrin inhibits STIM-1-mediated store-operated calcium entry, which prevents NFATc3 translocation to the nucleus and reduces the expression of downstream inflammatory factors. Additionally, it induces heme oxygenase HO-1 expression and modulates the ERK/p38 MAPK pathway, mitigating the production of pro-inflammatory cytokines and adhesion molecules. Rhamnocitrin is suitable for research focused on endothelial-related inflammatory diseases and neuroprotection.
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets the STIM-1, NFATc3, and MAPK pathways. It effectively scavenges free radicals and exhibits a specific inhibitory effect on oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Through upregulation of miR-185, Rhamnocitrin inhibits STIM-1-mediated store-operated calcium entry, which prevents NFATc3 translocation to the nucleus and reduces the expression of downstream inflammatory factors. Additionally, it induces heme oxygenase HO-1 expression and modulates the ERK/p38 MAPK pathway, mitigating the production of pro-inflammatory cytokines and adhesion molecules. Rhamnocitrin is suitable for research focused on endothelial-related inflammatory diseases and neuroprotection.
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