Catalog No.
Product Name
Application
Product Information
Citations
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HO-1 inhibitor
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2.- Beixian Zhou, .et al. , MedComm, 2024, Apr 12;5(4):e531 PMID: 38617435
- Ethyl Ferulate induces heme oxygenase-1 and protects rat neurons against oxidative stress.
- Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Upon administration, polaprezinc increases the expression of various anti-oxidant enzymes, such as superoxide dismutase 1 (SOD-1), SOD-2, heme oxygenase-1 (HO-1), glutathione S-transferase (GST), glutathione peroxidase (GSH-px), peroxidredoxin-1 (PRDX1; PRXI) and PRXD5 (PRXV) in the gastric mucosa, which protect cells against reactive oxygen species (ROS).
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HO inhibitor
Tin(IV) mesoporphyrin IX dichloride (Stannsoporfin) is a heme oxygenase (HO) inhibitor being developed for the prevention of hyperbilirubinemia in infants at risk of developing jaundice, extracted from patent WO2011103196A1. -
heme oxygenase 1 (HO-1) inhibitor
HO-1-IN-1 hydrochloride (Compound 2) is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 250 nM. -
Heme oxygenase-1 inducer
Coniferaldehyde (Ferulaldehyde), isolated from the ethanol extract of Vitex rotundifolia fruits, is an effective inducer of heme oxygenase-1 (HO-1). -
anti-inflammatory agent
Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis. - Ganodermanontriol, a sterol isolated from *Ganoderma lucidum*, exerts anti-inflammatory effects in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells by upregulating heme oxygenase-1 (HO-1) expression. It demonstrates hepatoprotective activity.
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HO-1 inhibitor
Tin protoporphyrin IX dichloride (SnPPIX) is a potent inhibitor of heme oxygenase-1 (HO-1), an enzyme involved in cellular stress responses and tumor progression. SnPPIX has been shown to sensitize pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mouse models, enhancing therapeutic efficacy and supporting its potential use as a chemosensitizing agent in cancer treatment. -
PDE4/NF-κB inhibitor
Sappanone A is an orally active homoisoflavone isolated from Caesalpinia sappan L., exhibiting notable anti-inflammatory and antioxidant properties. It functions as an inhibitor of phosphodiesterase 4 (PDE4) and NF-κB, key regulators of inflammatory signaling. Additionally, Sappanone A activates the Nrf2 pathway, leading to increased expression of the cytoprotective enzyme heme oxygenase-1 (HO-1). Sappanone A also inhibits RANKL-induced osteoclastogenesis, suggesting potential benefits in bone metabolism disorders. With its multifaceted bioactivity, Sappanone A holds significant promise for research in inflammation-related diseases, cardiovascular conditions, and bone health. -
HO-1 Inducer
Co(III) protoporphyrin IX chloride is a known inducer of heme oxygenase-1 (HO-1). This compound exhibits anti-inflammatory and antibacterial activities, making it valuable in the study of various pathological conditions. It is particularly useful in research involving ischemia-reperfusion injury models, providing insights into potential therapeutic strategies. -
Anti-cancer Agent
ME-344 is an isoflavone that functions as an anti-cancer agent, primarily by inhibiting tubulin polymerization and increasing mitochondrial reactive oxygen species (ROS) generation. This compound effectively induces apoptosis through the activation of caspase-3 and inhibits heme oxygenase-1 (HO-1), affecting its mitochondrial translocation. ME-344 exhibits synergistic effects with Vinblastine in leukemia cells and displays significant anti-tumor activity against leukemia and lung tumors. It is a valuable reagent for research on lung cancer, acute myeloid leukemia, and HER2-negative breast cancer. -
Anti-inflammatory Agent
Delmitide (RDP58) is an orally active d-isomer decapeptide that functions as a potent anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IFN-γ, and interleukin (IL)-12, while also up-regulating heme oxygenase 1 activity. Delmitide is valuable for research applications focused on ulcerative colitis and other inflammatory conditions. -
Antiinflammatory Agent
Ethyl linoleate, an unsaturated fatty acid derivative, acts as an anti-inflammatory agent by inhibiting the Akt/GSK3β/β-catenin signaling pathway and blocking NF-κB activation. Additionally, it induces heme oxygenase-1 and inhibits tyrosinase, contributing to its whitening and anti-inflammatory properties. Ethyl linoleate promotes absorption of compounds and has notable implications for atherosclerosis research. Its applications extend to the study of various inflammatory diseases and cosmetic formulations. -
Angiotensin Receptor Inhibitor
YS-49 monohydrate is a selective angiotensin receptor inhibitor, primarily targeting the angiotensin II pathway. This compound effectively reduces angiotensin II-stimulated proliferation of vascular smooth muscle cells by inducing heme oxygenase-1, offering potential therapeutic insights for cardiovascular research. Additionally, as an isoquinoline alkaloid, YS-49 demonstrates significant positive inotropic effects through the activation of cardiac β-adrenoceptors, making it a valuable reagent for studies involving cardiac function and vascular biology. -
HO-1 Inducer
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) acts as an inducer of heme oxygenase-1 (HO-1) through the activation of the Nrf2-antioxidant response element (ARE) signaling pathway. This compound promotes the upregulation of various antioxidant genes, providing protective effects against oxidative stress. Additionally, HPO-DAEE exhibits histone deacetylase inhibition, leading to increased expression of extracellular superoxide dismutase via histone acetylation. It has demonstrated efficacy in mitigating cell death induced by 6-hydroxydopamine through the activation of both the Nrf2-ARE and eIF2α-ATF4 pathways, making it a valuable tool for research in oxidative stress-related studies. -
TrxR1 Inhibitor
CS47 is a reversible inhibitor of Thioredoxin reductase 1 (TrxR1). It activates stress-responsive pathways involving glutathione (GSH) and iron regulation, leading to GSH depletion, heightened heme oxygenase-1 (HO-1) expression, and intracellular iron overload, ultimately inducing ferroptosis in KRAS-independent lung cancer models. CS47 demonstrates significant anticancer activity while exhibiting low cytotoxicity towards normal lung fibroblasts, making it a valuable tool for studying cancer mechanisms and therapeutic strategies. -
Ferroptosis Inducer
Ferroptosis inducer-2 is a potent inducer of heme oxygenase-1 (HO-1) that facilitates the process of ferroptosis. It demonstrates significant anticancer activity against triple-negative breast cancer (TNBC) cells by promoting iron-dependent cell death. This compound is valuable for research focused on exploring the mechanisms of ferroptosis and developing novel therapeutic strategies for cancer treatment. -
MGF Derivative
MGF24 is a protease-resistant derivative of mechanical growth factor (MGF) that primarily targets the neuroprotective pathway. It protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA)-induced apoptosis by inducing the expression of Heme oxygenase-1 (HO-1). MGF24 activates Protein Kinase C epsilon (PKC-ε) to stimulate Nrf2 activity, leading to enhanced HO-1 levels. This compound demonstrates significant neuroprotective effects and has potential applications in research related to neurological disorders such as stroke, nerve injury, and amyotrophic lateral sclerosis, as well as providing cardioprotective benefits in myocardial ischemia models. -
Anti-inflammatory Agent
NLRP3-IN-72 is a benzimidazole derivative that functions as an anti-inflammatory agent by specifically targeting the NLRP3 inflammasome. It demonstrates significant biological activity with an IC50 of 0.3 μM for inhibiting NLRP3-mediated IL-1β secretion, a PD50 of 0.4 μM for protecting against pyroptosis, and an EC50 of 0.6 μM for the induction of heme oxygenase-1 (HO-1). These properties make NLRP3-IN-72 a valuable tool for research into inflammatory processes and potential therapeutic interventions. -
HIFU Enhancer
Perfluorohexane functions as a HIFU (high-intensity focused ultrasound) enhancer, improving the efficacy and precision of ultrasound therapies while minimizing collateral damage to surrounding tissues. This perfluorocarbon compound has been shown to elevate the levels of heme oxygenase-1 (HO-1) and interleukin-10 (IL-10), thereby exhibiting antioxidant properties. Additionally, perfluorohexane plays a significant role in mitigating lung injury induced by lipopolysaccharide (LPS), making it a valuable tool for research into acute lung injury and related therapeutic applications. -
HO-1 Inhibitor
OB-24 is a selective small-molecule inhibitor of heme oxygenase-1 (HO-1), demonstrating an IC50 of 1.9 μM for HO-1 with minimal effect on HO-2 (IC50 > 100 μM). This compound exhibits significant anti-tumor and anti-metastatic activities, making it valuable for research applications in various cancer models, including prostate cancer, melanoma, ovarian carcinoma, and lung metastasis. OB-24 may serve as an essential tool for understanding HO-1's role in tumor progression and metastasis. -
HO-1 Inducer
CP-312 is a potent inducer of Heme Oxygenase-1 (HO-1), which plays a critical role in the cellular response to oxidative stress. By enhancing the expression of HMOX1, CP-312 supports the viability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). This compound is primarily utilized in research applications focusing on cardiovascular protection and oxidative stress mitigation in cardiac cells. -
HO-2 Inhibitor
Heme Oxygenase-2-IN-1 is a selective inhibitor of heme oxygenase-2 (HO-2), demonstrating an IC50 of 0.9 μM for HO-2 and 14.9 μM for HO-1. This compound is valuable in research applications focused on elucidating the role of HO-2 in various biological processes and potential therapeutic interventions. Its specificity for HO-2 makes it a useful tool for studying associated signaling pathways and related diseases. -
HO-1 Inducer
Cobalt protoporphyrin IX (Co-PPIX) is a specific inducer of heme oxygenase-1 (HO-1). This compound demonstrates significant antiviral activity against Influenza A virus (IAV) and is widely used in research to investigate the protective roles of HO-1 in various disease models. Co-PPIX serves as a valuable tool for studying the signaling pathways involved in oxidative stress and inflammation. -
Neuroprotective Agent
Leteprinim potassium (AIT-082) is a purine analog that functions as a neuroprotective agent. This compound enhances cognitive function by promoting the production of brain-derived neurotrophic factor (BDNF) mRNA in response to spinal cord injuries, and nerve growth factor (NGF) mRNA in the basal forebrain. Additionally, Leteprinim potassium mitigates glutamate-induced toxicity in cultured hippocampal neurons and elevates the mRNA levels of heme oxygenase 1 and 2, contributing to cellular defense against reactive oxygen species. Its applications extend to research on neuroprotection and cognitive enhancement strategies. -
Enantiomer
(3S,4R)-ME-344 is a selective inhibitor of mitochondrial heme oxygenase 1 (HO-1) that functions by binding to and modifying the structure of HO-1. This enantiomer promotes the translocation of HO-1 from the rough endoplasmic reticulum to the mitochondria specifically in drug-sensitive cell lines such as H460 and SHP-77. By decreasing mitochondrial ATP production and inducing reactive oxygen species (ROS), it disrupts redox homeostasis and mitochondrial function. With its notable antitumor activity, (3S,4R)-ME-344 is a valuable compound for research in cancer, including studies focused on breast cancer. -
Antioxidant
Tricetinidin chloride is an antioxidant that targets oxidative stress. It exhibits protective effects on rat renal cells by reducing reactive oxygen species (ROS) production, enhancing glutathione (GSH) levels, restoring mitochondrial membrane potential, and upregulating heme oxygenase-1 (HO-1) expression. Additionally, Tricetinidin chloride inhibits the expression of immunoglobulin E (IgE) receptors on human mast cells, making it a valuable tool for researching inflammatory and allergic diseases. -
Stable Isotope
Sulforaphane-d8 is a deuterium-labeled derivative of sulforaphane, targeting the Keap1/Nrf2/ARE signaling pathway. This compound is an effective inducer of tumor-suppressing proteins and has been shown to inhibit histone deacetylase (HDAC) activity. Sulforaphane-d8 provides cardioprotective effects by enhancing heme oxygenase-1 (HO-1) expression and has demonstrated potential in suppressing high glucose-induced pancreatic cancer through AMPK-dependent signaling. This reagent is valuable for anticancer and anti-inflammatory research applications. -
Anticancer Agent
Thiabenzanilide 63T is a small molecule anticancer agent that selectively triggers cancer cell death through a caspase-independent pathway. It generates reactive oxygen species and promotes lipid peroxidation, exhibiting strong cytotoxic effects against lung-derived cancer cell lines. Additionally, Thiobenzanilide 63T significantly reduces the expression of heme oxygenase (HO-1) in A549 cells, making it valuable for research in cancer biology and therapeutic development. -
PPARγ Inhibitor, heme oxygenase-1 Activator, Nrf2 Activator
PIISVYWK is a potent PPARγ inhibitor that also acts as an activator of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2). This compound effectively modulates the HO-1/Nrf2 signaling pathway, contributing to the reduction of oxidative stress and inflammation, while also exhibiting anti-obesity properties. PIISVYWK is suitable for research applications focused on obesity and related metabolic disorders. -
Reactive Oxygen Species Inhibitor
Heme Oxygenase-1-IN-2 is a selective inhibitor of heme oxygenase-1, exhibiting an IC50 of 0.95 μM. This compound demonstrates significant antiproliferative activity in vitro, making it a valuable tool in the study of reactive oxygen species and their roles in cellular processes. Its application extends to research involving oxidative stress and potential therapeutic interventions in various diseases related to dysregulated oxidative pathways. -
HO Inhibitor
N'-Isonicotinoylisonicotinohydrazide is a competitive inhibitor of heme oxygenase (HO), demonstrating an IC50 range of 5-30 μM. This compound significantly impedes iron release, thereby disrupting iron acquisition in bacteria. It exhibits selective inhibitory effects on HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis, making it a valuable tool for investigating multidrug-resistant Gram-negative bacterial infections. -
Heme oxygenase-1 Inducer
HIF-PHD-IN-3 is a potent inducer of heme oxygenase-1 (HO-1) through inhibition of hypoxia-inducible factor prolyl hydroxylases (HIF-PHDs). This compound exhibits cardioprotective properties, making it valuable in research focused on cardiac cell survival and stress responses. HIF-PHD-IN-3 is primarily utilized in studies investigating the role of HO-1 in cardiovascular health and various pathophysiological conditions. -
HO-1 Inhibitor
Dehydrocurdione, a sesquiterpene derived from zedoary, acts as a heme oxygenase-1 (HO-1) inhibitor. It is known to induce the expression of HO-1 in RAW 264.7 macrophages through interaction with Keap1, leading to the translocation of Nrf2 and activation of the HO-1 E2 enhancer. Additionally, Dehydrocurdione demonstrates anti-inflammatory properties by suppressing lipopolysaccharide-induced nitric oxide release, marking its potential application in research related to inflammation and oxidative stress. -
HO-1/HO-2 Inhibitor
Azalanstat is an imidazole-dioxolane derivative that functions as a specific inhibitor of heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2), with IC50 values of 5.5 µM and 24.5 µM, respectively. This compound is valuable for studying the roles of HO-1 and HO-2 in various biological processes, including inflammation and oxidative stress. Its inhibition properties make Azalanstat a useful tool in research focused on diseases where the modulation of heme oxygenase activity is relevant. -
Anti-Inflammatory Agent
Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets the STIM-1, NFATc3, and MAPK pathways. It effectively scavenges free radicals and exhibits a specific inhibitory effect on oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Through upregulation of miR-185, Rhamnocitrin inhibits STIM-1-mediated store-operated calcium entry, which prevents NFATc3 translocation to the nucleus and reduces the expression of downstream inflammatory factors. Additionally, it induces heme oxygenase HO-1 expression and modulates the ERK/p38 MAPK pathway, mitigating the production of pro-inflammatory cytokines and adhesion molecules. Rhamnocitrin is suitable for research focused on endothelial-related inflammatory diseases and neuroprotection. -
Heme Oxygenase Inhibitor
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol is a potent inhibitor of heme oxygenase (HO), a key enzyme involved in the degradation of heme to bilirubin. By inhibiting HO activity, this compound can effectively reduce the release of hypothalamic hormones such as arginine vasopressin (AVP), oxytocin (OT), and atrial natriuretic peptide (ANP) under hyperosmotic conditions. Its application extends to research involving hyperbilirubinemia and the physiological implications of HO modulation. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
Stable Isotope
trans-Isoferulic acid-d3 is a deuterium-labeled derivative of trans-Isoferulic acid, a naturally occurring aromatic acid derived from Clematis florida var. plena. This compound possesses notable anti-inflammatory properties, primarily through its ability to suppress nitric oxide (NO) and prostaglandin E2 (PGE2) production. Its mechanism of action involves the induction of Nrf2-dependent heme oxygenase-1 (HO-1), making it valuable for research into cellular stress responses and inflammation pathways. -
Bile Pigment
Biliverdin is a tetrapyrrolic pigment primarily involved in heme catabolism, generated through the enzymatic action of heme oxidase. This compound plays a significant role in mediating the protective effects of heme oxygenase-1 (HO-1) in various disease models, including ischemia-reperfusion injury (IRI) and organ transplantation. Biliverdin possesses notable biological activities, including anti-mutagenic, antioxidant, anti-inflammatory, and immunosuppressive properties, making it a valuable tool in research related to oxidative stress and inflammatory responses. -
Iron-containing Protein
Hemoglobin is an iron-containing protein found in red blood cells that primarily functions in oxygen transport and binding. It plays a crucial role in gas exchange by transporting carbon dioxide, nitric oxide, hydrogen sulfide, and sulfide. Additionally, hemoglobin acts as an inducer of heme oxygenase-1 (HO-1), contributing to antioxidant defense in tissues by absorbing excess oxygen. Its biological activity makes it a valuable reagent for studies in oxygen metabolism, respiratory physiology, and redox signaling. -
Heme Oxygenase Inhibitor
Zn(II) Mesoporphyrin IX is a potent inhibitor of heme oxygenase, particularly affecting the enzymatic activity in bone marrow. This compound demonstrates significant biological activity by inhibiting the growth of erythroid and myeloid progenitor cells, as well as blocking rhG-CSF-induced mobilization of these cells into peripheral blood. Zn(II) Mesoporphyrin IX is suitable for research applications involving hematopoietic regulation. However, its photochemical properties and potential toxicity to hematopoietic growth warrant careful consideration in experimental designs. -
Negative Control for Zn (II) Protoporphyrin
Cu(II) Protoporphyrin IX serves as a negative control for Zn(II) Protoporphyrin, which acts as an inhibitor of heme oxygenase. Heme oxygenase plays a significant role in various biological processes, including tumor cell resistance to chemotherapy, modulation of free radical formation, and management of inflammation. This reagent is valuable for studies investigating the pathways linked to vascular repair and the mechanistic understanding of heme oxygenase-related processes. -
Heme Oxygenase (HO) Inducer
Mn(III) Protoporphyrin IX Chloride is a potent inducer of heme oxygenase (HO) that enhances the expression of δ-aminolevulinate synthase and HO genes in chick embryo liver cells at a concentration of 10 μM. This metalloporphyrin is relevant for studying heme biosynthesis and degradation pathways. Additionally, Mn(III) protoporphyrin IX chloride has been utilized in the development of nanobialys for magnetic resonance imaging (MRI) of fibrin clots in vitro, as well as in the synthesis of metalloporphyrin conjugates with microperoxidase activity, further expanding its applications in chemical research. -
HO-1 Inducer
Probucol dithiobisphenol (DTBP) is a potent inducer of heme oxygenase 1 (HO-1) with notable antioxidant properties. It effectively inhibits atherosclerotic lesions in the aorta of Apoe−/− mice and promotes re-endothelialization, thereby reducing restenosis in rabbit arterial injury models. This compound is orally active, making it a valuable reagent for investigating vascular health and potential therapeutic applications in cardiovascular diseases. -
HO-1 Inhibitor
Heme Oxygenase-1-IN-3 is a selective inhibitor of heme oxygenase-1 (HO-1), characterized by a dissociation constant (Kd) of 141 nM. This compound is valuable for investigating the role of HO-1 in cancer progression and neurodegenerative diseases. Its specificity makes it an essential tool for researchers studying the mechanism of HO-1 and its implications in various pathological conditions.
