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Gamma-secretase inhibitor

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Catalog No. A10802

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
RO4929097 5mg A10802-5

Regular Price: €95.00

Special Price: €85.50

RO4929097 10mg A10802-10

Regular Price: €171.00

Special Price: €153.90

RO4929097 50mg A10802-50

Regular Price: €532.00

Special Price: €478.80

RO4929097 200mg A10802-200

Regular Price: €1,311.00

Special Price: €1,179.90

RO4929097 10mM * 1mL in DMSO A10802-10mM-D

Regular Price: €145.35

Special Price: €130.82

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.


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Publications citing Adooq Products
RO4929097 Citations (1)
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Chemical Information

Catalog Num A10802
Actions Inhibitor
M. Wt 469.4
Formula C22H20F5N3O3
Solubility DMSO>94mg/mL Water<1mg/mL Ethanol>16mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 847925-91-1
Synonyms N/A
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

Biological Activity

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM


Solubility (25°C) * In vitro DMSO 94 mg/mL (200.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (34.08 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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