RO4929097

Catalog No.: A10802

Gamma-secretase inhibitor

RO4929097

RO4929097 Chemical Structure

CAS NO. 847925-91-1

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
50 mg
$560.00
200 mg
$1,380.00
10mM * 1mL in DMSO
$153.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Biological Activity

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
Targets
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM
In vitro (25°C) DMSO 92 mg/mL (195.99 mM)
Water Insoluble
Ethanol 16 mg/mL
In vivo 2% DMSO+30% PEG 300+5% Tween+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04 mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10802
Actions Inhibitor
CAS No. 847925-91-1
Formula C22H20F5N3O3
M. Wt 469.4
Purity >98%
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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