RO4929097

Catalog No.: A10802

Gamma-secretase inhibitor

RO4929097 Chemical Structure

CAS NO. 847925-91-1

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$180.00
50 mg
$560.00
200 mg
$1,380.00
10mM * 1mL in DMSO
$153.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
Targets
γ secretase (Cell-free assay) γ secretase(ICN) (Cell-free assay) Aβ40 (Cell-free assay)
4 nM5 nM14 nM
In vitro (25°C) DMSO 94 mg/mL (200.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (34.08 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.52 mL 213.04 mL
0.5 mM 4.26 mL 21.3 mL 42.61 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10802
Actions Inhibitor
M. Wt 469.4
Formula C22H20F5N3O3
Solubility DMSO>94mg/mL Water<1mg/mL Ethanol>16mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 847925-91-1
Synonyms N/A
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3NC1=O

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