Sapurimycin is an antitumor antibiotic derived from Streptomyces DO-116, belonging to the capramycin family. It demonstrates potent activity against Gram-positive bacteria and exhibits significant antitumor efficacy against leukemia P388 and sarcoma 180 in murine models. In vitro assays reveal that Sapurimycin induces single-strand breaks in supercoiled plasmid DNA, highlighting its potential utility in genomic studies and cancer research.
Sapurimycin is an antitumor antibiotic derived from Streptomyces DO-116, belonging to the capramycin family. It demonstrates potent activity against Gram-positive bacteria and exhibits significant antitumor efficacy against leukemia P388 and sarcoma 180 in murine models. In vitro assays reveal that Sapurimycin induces single-strand breaks in supercoiled plasmid DNA, highlighting its potential utility in genomic studies and cancer research.
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