Semagacestat (LY450139)

Catalog No.: A10836

Gamma-secretase inhibitor

Semagacestat (LY450139)

Semagacestat (LY450139) Chemical Structure

CAS NO. 425386-60-3

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$150.00
50 mg
$450.00
100 mg
$750.00
10mM * 1mL in DMSO
$120.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079

Biological Activity

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
Targets
γ secretase(Aβ42) (H4 human glioma cells) γ secretase(Aβ38) (H4 human glioma cells) γ secretase(Aβ40) (H4 human glioma cells) Notch (H4 human glioma cells)
10.9 nM12.0 nM12.1 nM14.1 nM
In vitro (25°C) DMSO 72 mg/mL (199.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol 41 mg/mL (113.43 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.67 mL 138.35 mL 276.7 mL
0.5 mM 5.53 mL 27.67 mL 55.34 mL
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL

*The above data is based on the productmolecular weight 361.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10836
Actions Inhibitor
M. Wt 361.4
Formula C19H27N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 425386-60-3
Synonyms LY-450139
SMILES C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[[email protected]](C(C)C)O

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