Semagacestat (LY450139)

Catalog No.: A10836

Gamma-secretase inhibitor

Semagacestat (LY450139)

Semagacestat (LY450139) Chemical Structure

CAS NO. 425386-60-3

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $63.00

Special Price $50.40

10 mg

Regular Price: $107.00

Special Price $85.60

50 mg

Regular Price: $315.00

Special Price $252.00

100 mg

Regular Price: $1,071.00

Special Price $856.80

10mM * 1mL in DMSO

Regular Price: $120.00

Special Price $96.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079

Biological Activity

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
Targets
γ secretase(Aβ42) (H4 human glioma cells) γ secretase(Aβ38) (H4 human glioma cells) γ secretase(Aβ40) (H4 human glioma cells) Notch (H4 human glioma cells)
10.9 nM12.0 nM12.1 nM14.1 nM
In vitro (25°C) DMSO 66 mg/mL (182.6 mM)
Water Insoluble
Ethanol 38 mg/mL (105.13 mM)
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.67 mL 138.35 mL 276.7 mL
0.5 mM 5.53 mL 27.67 mL 55.34 mL
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL

*The above data is based on the productmolecular weight 361.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10836
Actions Inhibitor
CAS No. 425386-60-3
Formula C19H27N3O4
M. Wt 361.4
Purity >98%
Synonyms LY-450139
SMILES C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[[email protected]](C(C)C)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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