Signaling Pathway
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| Discription | Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. | ||
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| Targets |
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| Catalog Num | A10836 |
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| Formula | C19H27N3O4 |
| Molecular Weight | 361.4 |
| CAS Number | 425386-60-3 |
| SMILES | C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O |
| Synonyms | LY-450139 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 66 mg/mL (182.6 mM) | |
| Water | Insoluble | ||
| Ethanol | 38 mg/mL (105.13 mM) | ||
| In vivo | 0.5% methylcellulose | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.67 mL | 138.35 mL | 276.7 mL |
| 0.5 mM | 5.53 mL | 27.67 mL | 55.34 mL |
| 1 mM | 2.77 mL | 13.84 mL | 27.67 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
