Sorafenib Tosylate (Nexavar)

Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
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Product Name Price Stock Qty
Sorafenib Tosylate (Nexavar) 100mg
Special Price $40.00 Regular Price $50.00
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Sorafenib Tosylate 10mM * 1mL in DMSO
Special Price $48.00 Regular Price $60.00
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Adooq Products cited in reputable paper
Adooq's Sorafenib Tosylate (Nexavar) has been cited by 13 publications
  • Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591
  • Paula Sagmeister, .et al. , J Hepatocell Carcinoma, 2022, Jul 9;9:595-607 PMID: 35845819
  • Majid Momeny, .et al. , Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
  • Jindal A, .et al. , J Transl Sci, 2020, 7: 1-10
  • Mariko Fujisawa, .et al. , Anticancer Res, 2020, 40: 4445-4455 PMID: 32727774
  • Majid Momeny, .et al. , Eur J Pharmacol, 2020, 882:173298
  • Fangyuan Lai, .et al. , Stem Cell Res Ther, 2018, 9: 107 PMID: 29661222
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Arum Park, .et al. , J Cancer, 2017, 8(12): 2303-2311 PMID: 28819434
  • Cong Li, .et al. , Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Zhihong Li, .et al. , J Med Chem, 2014, Apr 24;57(8):3430-49 PMID: 24641103
  • Hideki Yamaguchi, .et al. , Cancer Sci, 2014, 105(5): 528-536 PMID: 24612061
  • Yaping Zhang, .et al. , J Pharmacokinet Pharmacodyn., 2014, 41(6): 675-691 PMID: 25326874
  • Biological Activity
    Discription Sorafenib Tosylate (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF.
    Targets
    Target Value
    Product Information
    Catalog Num A10001
    Formula C21H16ClF3N4O3.C7H8O3S
    Molecular Weight 637
    CAS Number 475207-59-1
    SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
    Synonyms Bay 43-9006
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 114 mg/mL (178.95 mM)
    Water <1 mg/mL
    Ethanol Insoluble
    In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 15.7 mL 78.49 mL 156.99 mL
    0.5 mM 3.14 mL 15.7 mL 31.4 mL
    1 mM 1.57 mL 7.85 mL 15.7 mL
    5 mM 0.31 mL 1.57 mL 3.14 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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