Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism.
Sulfathiazole-d4 is a deuterium-labeled variant of Sulfathiazole, which serves as a selective antibiotic with specific endocrine-disrupting properties. It primarily targets the steroidogenic pathway by enhancing the activity of CYP19 in human adrenal cancer cells (H295R) while upregulating mRNA expression of CYP17, CYP19, and 3β-HSD. This compound is instrumental in increasing the production of 17-estradiol (E2) and has been shown to exert endocrine-disrupting effects in aquatic organisms, including species such as the Japanese medaka fish, making it a valuable tool for studies on endocrine disruption and steroid metabolism.
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