Sulfathiazole sodium is an orally active antibiotic that functions as an endocrine disruptor by targeting the steroidogenic pathway, specifically enhancing CYP19 activity in human adrenal cancer cells (H295R) and upregulating the expression of mRNAs for CYP17, CYP19, and 3β-HSD. It significantly increases the production of 17-estradiol (E2) and exhibits endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish. Additionally, sulfathiazole sodium serves as a cathodic corrosion inhibitor, effectively reducing copper corrosion in the presence of chloride ions through both chemical and physical adsorption mechanisms.
Sulfathiazole sodium is an orally active antibiotic that functions as an endocrine disruptor by targeting the steroidogenic pathway, specifically enhancing CYP19 activity in human adrenal cancer cells (H295R) and upregulating the expression of mRNAs for CYP17, CYP19, and 3β-HSD. It significantly increases the production of 17-estradiol (E2) and exhibits endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish. Additionally, sulfathiazole sodium serves as a cathodic corrosion inhibitor, effectively reducing copper corrosion in the presence of chloride ions through both chemical and physical adsorption mechanisms.
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