Sulfathiazole is an antibiotic with notable activity as an endocrine disruptor, primarily targeting the steroidogenic pathway by enhancing CYP19 activity in human adrenal cancer cells (H295R). This compound also upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD, leading to increased production of 17-estradiol (E2). Additionally, sulfathiazole demonstrates endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish, making it relevant for studies in environmental toxicology and endocrine disruption research.
Sulfathiazole is an antibiotic with notable activity as an endocrine disruptor, primarily targeting the steroidogenic pathway by enhancing CYP19 activity in human adrenal cancer cells (H295R). This compound also upregulates the mRNA expression of CYP17, CYP19, and 3β-HSD, leading to increased production of 17-estradiol (E2). Additionally, sulfathiazole demonstrates endocrine-disrupting effects in aquatic organisms, such as the Japanese medaka fish, making it relevant for studies in environmental toxicology and endocrine disruption research.
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