Taurolithocholic acid is a bile acid recognized for its role as a ferroptosis suppressor. It activates the TGR5-PI3K/AKT-SREBP2 signaling pathway, leading to the upregulation of FADS2, which inhibits SFTSV-induced ferroptosis and viral replication, while also modulating pro-inflammatory cytokines such as IL-1β. In addition to its antiviral properties, taurolithocholic acid influences hepatocellular transport processes, promoting cholestatic effects. This compound serves as a valuable experimental model for studying hepatocellular cholestasis and provides insight into severe fever with thrombocytopenia syndrome without exhibiting cytotoxicity at concentrations ≤200 μM.
Taurolithocholic acid is a bile acid recognized for its role as a ferroptosis suppressor. It activates the TGR5-PI3K/AKT-SREBP2 signaling pathway, leading to the upregulation of FADS2, which inhibits SFTSV-induced ferroptosis and viral replication, while also modulating pro-inflammatory cytokines such as IL-1β. In addition to its antiviral properties, taurolithocholic acid influences hepatocellular transport processes, promoting cholestatic effects. This compound serves as a valuable experimental model for studying hepatocellular cholestasis and provides insight into severe fever with thrombocytopenia syndrome without exhibiting cytotoxicity at concentrations ≤200 μM.
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