Telaprevir (VX-950)

Name: Telaprevir (VX-950)
Brand: Adooq Bioscience
SKU: A10902
Rating: 100 (9 reviews)

Catalog No.: A10902

HCV NS3-4A protease inhibitor

Product Citations (9)

Telaprevir (VX-950) Chemical Structure

CAS NO. 402957-28-2

Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.

Availability: In stock

Package	Price	Qty
2 mg	$60.00
5 mg	$90.00
10 mg	$160.00
25 mg	$320.00
10mM * 1mL in DMSO	$180.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Telaprevir (VX-950)

Mahim Khan, .et al. Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease, BMC Complement Med Ther, 2022, Apr 2;22(1):98 PMID: 35366855
Adita Ayu Permanasari, .et al. An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs, BMC Complement Med Ther, 2021, Oct 12;21(1):260 PMID: 34641875
Che C Colpitts, .et al. Hepatitis C virus exploits cyclophilin A to evade PKR, eLife, 2020, 9: e52237 PMID: 32539931
TS Wahyuni, .et al. Enhancement of Anti-Hepatitis C Virus Activity by the Combination of Chalepin From Ruta Angustifolia and Current Antiviral Drugs, Southeast Asian J Trop Med public health, 2020, 51(1)
Stefan Bittmann, .et al. TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat, J Regen Biol Med, 2020, 2(2):1-3
Wahyuni TS, .et al. Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor, J Basic Clin Physiol Pharmacol, 2019, Dec 14 PMID: 31837259
Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
Apriyanto DR, .et al. Anti-Hepatitis C Virus Activity of a Crude Extract from Longan (Dimocarpus longan Lour.) Leaves, Jpn J Infect Dis, 2016, May 20;69(3):213-20 PMID: 26255732
Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352

Biological Activity

Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.

Targets

HCV NS3-4A serine protease
0.35 μM

Solubility *

In vitro (25°C)	DMSO	131 mg/mL (192.69 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.71 mL	73.54 mL	147.08 mL
0.5 mM	2.94 mL	14.71 mL	29.42 mL
1 mM	1.47 mL	7.35 mL	14.71 mL
5 mM	0.29 mL	1.47 mL	2.94 mL

*The above data is based on the productmolecular weight 679.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10902
Actions	Inhibitor
CAS No.	402957-28-2
Formula	C36H53N7O6
M. Wt	679.9
Purity	>98%
Synonyms	VX950, Incivek, Incivo
SMILES	CCC[[email protected]@H](C(=O)C(=O)NC1CC1)NC(=O)[[email protected]@H]2[[email protected]]3CCC[[email protected]]3CN2C(=O)[[email protected]](C(C)(C)C)NC(=O)[[email protected]](C4CCCCC4)NC(=O)C5=NC=CN=C5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.