Telaprevir (VX-950)

Catalog No.: A10902

HCV NS3-4A protease inhibitor

Telaprevir (VX-950)

Telaprevir (VX-950) Chemical Structure

CAS NO. 402957-28-2

Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$90.00
10 mg
$160.00
25 mg
$320.00
10mM * 1mL in DMSO
$180.00
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  • Che C Colpitts, .et al. Hepatitis C virus exploits cyclophilin A to evade PKR, eLife, 2020, 9: e52237 PMID: 32539931
  • Stefan Bittmann, .et al. TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat, J Regen Biol Med, 2020, 2(2):1-3
  • TS Wahyuni, .et al. Enhancement of Anti-Hepatitis C Virus Activity by the Combination of Chalepin From Ruta Angustifolia and Current Antiviral Drugs, Southeast Asian J Trop Med public health, 2020, 51(1)
  • Wahyuni TS, .et al. Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor, J Basic Clin Physiol Pharmacol, 2019, Dec 14 PMID: 31837259
  • Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
  • Apriyanto DR, .et al. Anti-Hepatitis C Virus Activity of a Crude Extract from Longan (Dimocarpus longan Lour.) Leaves, Jpn J Infect Dis, 2016, May 20;69(3):213-20 PMID: 26255732
  • Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352

Biological Activity

Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
Targets
HCV NS3-4A serine protease
0.35 μM
In vitro (25°C) DMSO 136 mg/mL (200.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.71 mL 73.54 mL 147.08 mL
0.5 mM 2.94 mL 14.71 mL 29.42 mL
1 mM 1.47 mL 7.35 mL 14.71 mL
5 mM 0.29 mL 1.47 mL 2.94 mL

*The above data is based on the productmolecular weight 679.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10902
Actions Inhibitor
M. Wt 679.9
Formula C36H53N7O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 402957-28-2
Synonyms VX950, Incivek, Incivo
SMILES CCC[[email protected]@H](C(=O)C(=O)NC1CC1)NC(=O)[[email protected]@H]2[[email protected]]3CCC[[email protected]]3CN2C(=O)[[email protected]](C(C)(C)C)NC(=O)[[email protected]H](C4CCCCC4)NC(=O)C5=NC=CN=C5

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