Tinostamustine hydrochloride is an HDAC inhibitor that exhibits potent anti-multiple myeloma activity. This compound promotes CD38 expression and enhances the acetylation of histone H3, which increases the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab. Additionally, Tinostamustine hydrochloride elevates the expression of MICA and MICB, thereby activating natural killer (NK) cells. Research indicates that this compound can significantly delay tumor growth and improve survival rates in murine models.
Tinostamustine hydrochloride is an HDAC inhibitor that exhibits potent anti-multiple myeloma activity. This compound promotes CD38 expression and enhances the acetylation of histone H3, which increases the sensitivity of tumor cells to the anti-CD38 monoclonal antibody daratumumab. Additionally, Tinostamustine hydrochloride elevates the expression of MICA and MICB, thereby activating natural killer (NK) cells. Research indicates that this compound can significantly delay tumor growth and improve survival rates in murine models.
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