Torin 2

Catalog No.: A11586

mTOR inhibitor

Torin 2

Torin 2 Chemical Structure

CAS NO. 1223001-51-1

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $110.00

Special Price $88.00

25 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $330.00

Special Price $264.00

100 mg

Regular Price: $490.00

Special Price $392.00

10mM * 1mL in DMSO

Regular Price: $111.00

Special Price $88.80

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Biological Activity

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
Targets
mTOR (p53?/? MEFs) ATM (PC3 cells) ATR (PC3 cells) DNA-PK (PC3 cells)
0.25 nM28 nM(EC50)35 nM(EC50)118 nM(EC50)
In vitro (25°C) DMSO 18 mg/mL (41.63 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 1.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.13 mL 115.63 mL 231.27 mL
0.5 mM 4.63 mL 23.13 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11586
Actions Inhibitor
CAS No. 1223001-51-1
Formula C24H15F3N4O
M. Wt 432.4
Purity >98%
Synonyms Torin2
SMILES C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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