Torin 2

Catalog No.: A11586

mTOR inhibitor

Torin 2

Torin 2 Chemical Structure

CAS NO. 1223001-51-1

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$200.00
50 mg
$330.00
100 mg
$490.00
10mM * 1mL in DMSO
$111.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
Targets
mTOR (p53?/? MEFs) ATM (PC3 cells) ATR (PC3 cells) DNA-PK (PC3 cells)
0.25 nM28 nM(EC50)35 nM(EC50)118 nM(EC50)
In vitro (25°C) DMSO 20 mg/mL (46.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.13 mL 115.63 mL 231.27 mL
0.5 mM 4.63 mL 23.13 mL 46.25 mL
1 mM 2.31 mL 11.56 mL 23.13 mL
5 mM 0.46 mL 2.31 mL 4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11586
Actions Inhibitor
M. Wt 432.4
Formula C24H15F3N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1223001-51-1
Synonyms Torin2
SMILES C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F

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