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- Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789
Biological Activity
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
Targets
| mTOR (p53?/? MEFs) | ATM (PC3 cells) | ATR (PC3 cells) | DNA-PK (PC3 cells) | |
| 0.25 nM | 28 nM(EC50) | 35 nM(EC50) | 118 nM(EC50) |
| In vitro (25°C) | DMSO | 18 mg/mL (41.63 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1.4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.13 mL | 115.63 mL | 231.27 mL |
| 0.5 mM | 4.63 mL | 23.13 mL | 46.25 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.13 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11586 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1223001-51-1 |
| Formula | C24H15F3N4O |
| M. Wt | 432.4 |
| Purity | >98% |
| Synonyms | Torin2 |
| SMILES | C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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