Catalog No.
Product Name
Application
Product Information
Citations
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SOCE inhibitor
SOCE inhibitor 1 is a store-operated calcium entry (SOCE) inhibitor with an IC50 of 4.4 μM. -
lipophilic calcium channel blocker
Teludipine is a lipophilic calcium channel blocker. -
Cav 2.2 blocker
Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain, with an IC50 of 1 nM. -
L-type calcium antagonist
Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. -
Calcium Channel antagonist
Fantofarone is a highly potent Calcium Channel antagonist. -
NAADP antagonist and TPC blocker
trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations. -
ligand for the α2δ subunit of voltage-gated calcium channels
Mirogabalin besylate is a selective and orally available ligand for the α2δ subunit of voltage-gated calcium channels, with Kds of 13.5 nM, 22.7 nM, 27 nM, and 47.6 nM for human α2δ-1, human α2δ-2, rat α2δ-1, and rat α2δ-2, respectively. -
CRAC inhibitor
CM-4620 is a calcium-release activated calcium-channel (CRAC) inhibitor, with IC50s of 119, 895 nM for Orai1/STIM1 and Orai2/STIM1 channels, respectively. -
calcium channel blocker
ACT-709478 is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies. -
Calcium channel blocker
(S)-Amlodipine is a (S)-Enantiomer of Amlodipine and a dihydropyridine calcium channel blocker with activity resides mainly in the (-)-isomer. -
Calcium-Sensing Receptor Antagonist
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. -
Calcium channel blocker
NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. -
elastogenesis inhibitor
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor. -
NF-κB Expression Reducer, ERK 1/2 Activator, Beta-Adrenergic Receptor Modulator, Calcium Channel Inhibitor
Eupatorin is a flavonoid that functions primarily as an NF-κB expression reducer and an ERK 1/2 activator, while also modulating beta-adrenergic receptors and inhibiting calcium channels. It demonstrates significant antiproliferative and vasodilatory effects, inducing apoptosis and causing G2/M phase cell cycle arrest, alongside reactive oxygen species (ROS) production. Eupatorin has been shown to impact inflammatory mediators and calcium signaling pathways, making it relevant for research in breast cancer, hypertension, and leukemia. Metabolized by CYP1A1 and other CYP1 enzymes, Eupatorin yields bioactive metabolites that maintain antiproliferative properties. -
Calcium Channel Modulator
4-Bromo A23187 is a halogenated analog of the selective calcium ionophore A-23187, acting as a calcium channel modulator. This compound facilitates the transport of calcium ions across cellular membranes, leading to increased intracellular calcium levels. It has demonstrated efficacy in inducing apoptosis in various cell types, including HL-60 cells, and is useful for research applications related to calcium-mediated signaling pathways and cell death mechanisms. -
Calcium Antagonist
Cycleanine is a potent vascular-selective calcium antagonist known for its analgesic, muscle relaxant, and anti-inflammatory properties. This compound exhibits potential anti-ovarian cancer effects by modulating the apoptosis pathway, making it a valuable tool for research in oncology and pain management. Its calcium-blocking mechanism allows for further exploration into vascular functions and related biological systems. -
Calcium Channel Antagonist
Benidipine is a potent orally active calcium channel antagonist. It exhibits anti-apoptotic effects in ischemic/reperfused myocardial cells and enhances the activity of endothelial cell-type nitric oxide synthase. Additionally, Benidipine has been shown to improve coronary circulation in hypertensive rat models, making it valuable for research on cardiovascular health and related disorders. -
Calcium Channel Blocker
Dotarizine is a selective calcium channel blocker that functions by inhibiting Ca2+ influx. This compound demonstrates significant antimigraine activity through its modulation of calcium signaling pathways. Additionally, Dotarizine reduces the release of lactate dehydrogenase and exhibits the capacity to block 5-HT receptors, making it a valuable tool for research in neural signaling and migraine pathophysiology. -
Calcium Channel Blocker
Levemopamil hydrochloride is a calcium channel blocker that effectively penetrates the blood-brain barrier and acts as a 5-HT2 antagonist. This compound exhibits key biological activity in modulating calcium influx, making it valuable for research related to temporary occlusion and various neurological diseases. It serves as a useful tool for studying the effects of calcium channel modulation on neuronal function and pathophysiology. -
Calcium Channel Blocker
Levemopamil is a calcium channel blocker known for its ability to antagonize 5-HT2 receptors. It demonstrates renoprotective properties, particularly in the context of ischemic acute kidney injury. This compound is suitable for research involving ischemic acute renal failure and related nephroprotective studies. -
Calcium Antagonist
Nexopamil is a calcium antagonist that targets Ca2+ channels, as well as 5-HT2, 5-HT1A, 5-HT1C, and dopamine D2 receptors. This compound demonstrates significant vasodilatory and cardioprotective properties, along with the ability to inhibit platelet aggregation. Nexopamil is useful for research focused on conditions such as stable and unstable angina, as well as potentially in studies of peripheral arterial occlusive disease. -
Calcium Channel Agonist
(2R,3R)-Butane-2,3-diol functions as a reversible agonist of lanthanum-sensitive calcium channels in bacteria, specifically Escherichia coli, with an EC50 of approximately 25 mM. This compound interacts with calcium channel proteins, promoting channel opening and facilitating extracellular calcium influx, which leads to intracellular calcium transients. Such activity plays a crucial role in regulating bacterial physiological processes, including growth, metabolism, and signal transduction. Additionally, (2R,3R)-Butane-2,3-diol is valuable for investigating bacterial-host cell signaling dynamics and studying conditions like lactose intolerance and other related gastrointestinal disorders. -
Antiarrhythmic Agent
HNS-32 is an antiarrhythmic agent that demonstrates vasodilatory effects, providing protective benefits against ischemic and reperfusion arrhythmias in canine hearts. This compound exhibits significant negative chronotropic effects on mammalian ventricular myocardium, highlighting its potential for applications in acute coronary syndrome research. HNS-32 serves as a valuable tool for exploring the mechanisms and treatment options for cardiac arrhythmias. -
Calcium Antagonist
F-0401 is a calcium antagonist that exerts its effects through antagonism of the platelet-activating factor receptor (PAFR). This compound demonstrates significant potential in neurological research, particularly in studies related to stroke and related pathologies. Its ability to modulate calcium signaling pathways makes F-0401 a valuable tool for investigating therapeutic strategies in the context of neuroprotection and cerebrovascular disorders. -
Calcium Entry-Blocking
YM-430 is a calcium entry-blocking and beta-adrenoceptor-blocking agent. It effectively inhibits Amifampridine-induced rhythmic contractions with an IC50 value of 59.2 nM and blocks arginine vasopressin-induced ST-segment depression with an IC50 of 36.6 mg/kg. This compound is valuable for research into angina pectoris and related cardiovascular conditions. -
Calcium Influx/NO Modulator
Palmitoylglycine (N-palmitoyl glycine) is an endogenous lipid that functions as a modulator of calcium influx and nitric oxide production in sensory neurons. This compound is associated with an increased risk of Brugada syndrome (BrS) and interacts with various BrS-related proteins, displaying moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA. Palmitoylglycine is valuable in research investigating its roles in neuronal signaling and cardiovascular conditions linked to BrS. -
Calcium Channel Inhibitor
Ethacrynic acid sodium is an effective calcium channel inhibitor that primarily targets L-type voltage-dependent and store-operated calcium channels. This compound exhibits diuretic properties and significantly modulates glutathione S-transferases (GSTs) while inhibiting the NF-kB signaling pathway. Ethacrynic acid sodium demonstrates anti-inflammatory activity, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it a valuable tool in research focused on inflammation and airway smooth muscle relaxation. -
Calcium Channel Blockers
Levamlodipine hydrochloride is a dihydropyridine calcium channel blocker that primarily targets L-type calcium channels on vascular smooth muscle cells. By inhibiting calcium ion influx, it promotes vasodilation, effectively lowering blood pressure and alleviating angina. Additionally, its binding affinity to human serum albumin (HSA) enhances research into drug transport and release mechanisms within the body. This compound is beneficial for studies focused on cardiovascular therapies and mechanisms of action related to hypertension and coronary artery disease. -
Calcium Channel Inhibitor
Levamlodipine hydrobromide is a calcium channel inhibitor with notable antioxidant and vasodilatory properties. This compound has been shown to reduce serum malondialdehyde (MDA) levels while increasing superoxide dismutase (SOD) activity, thus improving oxidative stress responses. It is appropriate for research applications related to vascular dementia, hypertension, and cerebrovascular diseases. -
Calcium Channel Blocker
Levamlodipine besylate hemipentahydrate is a calcium channel blocker that exhibits significant antioxidant and vasodilatory effects. This compound has been shown to lower serum malondialdehyde (MDA) levels while enhancing superoxide dismutase (SOD) activity, thereby mitigating oxidative stress. Levamlodipine besylate hemipentahydrate is suitable for research applications focused on vascular dementia, hypertension, and cerebrovascular diseases. -
Calcium Channel
C18 LPA (PA(18:0e/0:0)) targets calcium channels and serves as a bioactive phospholipid involved in signal transduction via G protein-coupled receptors (GPCRs). This compound promotes smooth muscle contraction, chemotaxis, cytoskeletal rearrangement, and is implicated in neurotransmitter release and cell proliferation. Increased levels of C18 LPA in human plasma are correlated with ovarian cancer and atherosclerosis, indicating its potential utility as a biomarker in oncological and cardiovascular research. -
Sodium-Calcium Exchanger Inhibitor
KB-R7943 is a selective inhibitor of the sodium-calcium exchanger, exhibiting an IC50 value of 5.1 µM. This compound is utilized as a valuable tool in studies involving cardiac and renal failure models, facilitating research into calcium homeostasis and its implications in heart and kidney function. -
Calcium Channel Blocker
Suloctidil is an orally active calcium channel blocker that primarily targets vasoconstriction pathways. It effectively antagonizes vasoconstriction induced by norepinephrine, angiotensin, and serotonin, while also inhibiting platelet function and exhibiting neuroprotective effects. Additionally, Suloctidil demonstrates antifungal activity against Candida albicans, influencing biofilm formation and virulence. This compound is applicable in research focused on vasospasm relief, antithrombosis, and treatment of superficial candidiasis. -
Calcium Channel Antagonist
CP-060 is a potent calcium channel antagonist that effectively inhibits calcium overload in cells. This compound also exhibits notable antioxidant properties and offers cardioprotective effects. CP-060 is valuable for research applications focused on cardiovascular diseases and cellular stress responses. -
Calcium Channel Inhibitor
McN5691 is a voltage-sensitive calcium channel inhibitor that selectively blocks calcium influx through L-type calcium channels. This action leads to reduced calcium-dependent cellular events, making it a valuable tool for investigating calcium signaling pathways. McN5691 is particularly useful in research focused on cardiovascular physiology and the modulation of muscle contraction mechanisms. -
Calcium Channel Chemical
α2δ ligand 1 selectively interacts with the α2δ-1 subunit of voltage-gated calcium channels. This compound is known to modulate calcium influx, which plays a crucial role in neuronal excitability and synaptic transmission. It is utilized in research applications focused on pain management, neurological disorders, and the exploration of synaptic plasticity. -
Calcium Channel Antagonist
Dopropidil is a calcium channel antagonist that modulates intracellular calcium levels. It exhibits anti-anginal properties and demonstrates significant anti-ischemic effects in various predictive animal models. This compound is valuable for research in cardiovascular pharmacology, particularly in the study of angina and ischemic heart disorders. -
Calcium Channel Antagonist
Darodipine is a potent calcium channel antagonist that selectively inhibits L-type calcium channels. This compound demonstrates significant biological activity by decreasing intracellular calcium levels, which can effectively reduce vascular smooth muscle contraction. Darodipine is primarily utilized in research applications focused on cardiovascular physiology, hypertension studies, and the exploration of calcium signaling pathways. -
Dihydropyridine Calcium Antagonist
(S)-Nimodipine is a potent dihydropyridine calcium antagonist known for its selective effect on calcium channels. It exhibits significant biological activity, primarily in the management of cerebrovascular disorders by improving cerebral blood flow. This compound is especially valuable in research focusing on neurological conditions and the effects of calcium modulation in neuronal tissue. -
Calcium Channel Blocker
Verapamil hydrochloride is a calcium channel blocker primarily targeting L-type calcium channels. It exhibits potent inhibitory activity on P-glycoprotein and CYP3A4, contributing to its pharmacological profile. This compound is widely utilized in research related to hypertension, cardiac arrhythmias, and angina, facilitating studies on cardiovascular function and drug metabolism.
