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Catalog No.
Product Name
Application
Product Information
Citations
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SERCA Inhibitor
CAD204520 is a selective inhibitor of the Sarcoplasmic Reticulum Calcium ATPase (SERCA), demonstrating an IC50 value of 0.34 μM. This compound specifically targets mutated NOTCH1 proteins more effectively than wild-type, making it a valuable tool for studying T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL). CAD204520 is suitable for research aimed at understanding the molecular mechanisms and therapeutic strategies in these malignancies. -
Calcium Channel Inhibitor
Heteroclitin D is a lignan derived from Kadsura medicinal plants, functioning primarily as a calcium channel inhibitor. It exhibits significant biological activity by inhibiting L-type calcium channels, which are critical in various physiological processes. This compound is suitable for research applications focusing on calcium signaling, neuroprotection, and studies related to oxidative stress and lipid peroxidation. -
Calcium Channel Inhibitor
Yangambin is a furofuran lignan that functions as a calcium channel inhibitor, targeting voltage-gated Ca2+ channels. This compound effectively reduces intracellular calcium levels in vascular smooth muscle cells, promoting peripheral vasodilation. Additionally, Yangambin demonstrates antiallergic activity by inhibiting β-hexosaminidase release with an IC50 of 33.8 μM and exhibits anti-inflammatory properties with an IC50 of 37.4 μM, making it valuable for research in vascular biology and inflammation. -
Calcium Channel Inhibitor
PD0176078 is a selective N-type calcium channel inhibitor, primarily targeting voltage-gated calcium channels. It exhibits significant biological activity by effectively blocking calcium influx, which modulates neurotransmitter release and can influence pain signaling pathways. This compound is valuable for research applications focused on neuropharmacology and the investigation of pain mechanisms. -
Cav3.1/Cav3.2/Cav3.3 Inhibitor
ML218 hydrochloride is a selective inhibitor of T-type calcium channels, specifically Cav3.1, Cav3.2, and Cav3.3, exhibiting IC50 values of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. This compound effectively inhibits burst activity in subthalamic nucleus neurons and demonstrates minimal interference with L- or N-type calcium channels, KATP channels, or hERG potassium channels. Additionally, ML218 hydrochloride has the capability to penetrate the blood-brain barrier, making it a valuable tool for neurological research applications. -
Calcium Channel Inhibitor
Etripamil hydrochloride is a potent L-type calcium channel inhibitor primarily used in the research of paroxysmal supraventricular tachycardia (PSVT). By blocking calcium influx through slow calcium channels, it effectively slows down atrioventricular node conduction and extends the refractory period of the atrioventricular node. This compound is valuable for studying cardiac electrophysiology and the mechanisms underlying arrhythmias. -
CaVAb Inhibitor
UK-59811 hydrochloride is a Br-dihydropyridine derivative that functions as a potent inhibitor of the bacterial homotetrameric voltage-gated calcium channel, CaVAb, with an IC50 value of 194 nM. It serves as a valuable tool for studying calcium ion transport and its physiological implications in bacterial systems. Its specific action on CaVAb makes it suitable for research applications focused on calcium signaling and channel modulation. -
T-type Calcium Channel Inhibitor
IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 µM. This compound is primarily utilized in research related to epilepsy, aiding in the investigation of calcium channel modulation and its effects on neuronal excitability. IAA65 may facilitate the exploration of therapeutic strategies targeting T-type calcium channels for seizure management. -
T-type Calcium Channel Inhibitor
IAB15 is a potent inhibitor of T-type calcium channels, which play a crucial role in regulating neuronal excitability and neurotransmitter release. This compound demonstrates significant activity in modulating calcium ion influx, making it a valuable tool in epilepsy research. Its ability to selectively target these channels positions IAB15 as an important reagent for studying calcium signaling pathways and their implications in seizure disorders. -
Potassium/Sodium Channel Inhibitor
Huwentoxin I is a peptide toxin that specifically inhibits voltage-gated sodium channels and N-type calcium channels. This compound has demonstrated significant inhibitory effects on sodium channels in both rat hippocampus and cockroach dorsal unpaired median (DUM) neurons, with IC50 values of 66.1 nM and 4.80 nM, respectively. Huwentoxin I is valuable for studies focused on neuronal excitability and channelopathy-related research applications. -
Cav 3.2 Inhibitor
Cav 3.2 inhibitor 1 is a selective inhibitor of the Cav 3.2 T-type calcium channel, exhibiting minimal interaction with dopamine D2 receptors. This compound is valuable for studying mechanisms underlying somatic and visceral pain, making it a significant tool in pain research and potential therapeutic development. -
Cav 3.2 Inhibitor
Cav 3.2 Inhibitor 4 is a selective inhibitor targeting the Cav 3.2 T-type calcium channel, exhibiting an IC50 of 0.6 μM. This compound is primarily researched for its potential in investigating atrial fibrillation and related cardiac conditions. Its peripheral restriction enhances its utility in studying physiological processes influenced by Cav 3.2 activity in diverse experimental settings. -
Calcium Channel Inhibitor
Calcicludine is a potent inhibitor of high-voltage-activated calcium channels, with a particular affinity for L-type calcium channels. Derived from the venom of the green mamba, this protein toxin plays a critical role in studies investigating calcium signaling and neurotransmitter release. Its unique mechanism makes Calcicludine a valuable tool for researchers exploring neuronal excitability and muscle contraction pathways. -
Calcium Channel Blocker, Cholesterol Acyltransferase Inhibitor
Belfosdil functions as a selective calcium channel blocker while also inhibiting acyl coenzyme A cholesterol acyltransferase (ACAT). This dual action contributes to its role in modulating calcium influx and lipid metabolism. Belfosdil is utilized in research focused on cardiovascular and metabolic diseases, exploring its potential for therapeutic applications. -
Cavα2δ1/NET Inhibitor
Cavα2δ1&NET-IN-2 is a dual inhibitor targeting the α2δ-1 subunit of voltage-gated calcium channels and the norepinephrine transporter (NET). It demonstrates effective inhibition of Cavα2δ-1 with a Ki of 454 nM and exhibits potent inhibition of NET with a Ki of 59 nM and an IC50 of 7 nM. This compound is valuable for research focused on pain mechanisms and the associated neurotransmitter systems. -
Calcium Channel Inhibitor
Levosemotiadil is a calcium channel inhibitor that demonstrates increased binding affinity to human serum albumin (HSA) compared to its R-isomer. Research utilizing high-performance frontal analysis (HPFA) indicates that levosemotiadil binds approximately three times more strongly to HSA than semotiadil, with specific interactions at the diazepam binding site. The binding affinity of both enantiomers is diminished in the presence of diazepam, while warfarin shows no effect. These properties underscore levosemotiadil's potential as a Ca- and Na-channel blocker, making it a valuable compound for exploring its pharmacokinetics and therapeutic applications. -
Calcium Channels Inhibitor
ω-Grammotoxin SIA is a selective inhibitor of P/Q and N-type voltage-gated calcium channels, derived from spider venom. This protein toxin is instrumental in studying calcium's role in neuronal and cardiovascular signaling pathways. Its unique mechanism allows researchers to explore its potential applications in understanding and treating various neurological and cardiovascular diseases. -
α2δ-1 Inhibitor
(rel)-Mirogabalin is an inhibitor of the α2δ-1 subunit of voltage-dependent calcium channels. It is primarily used in research focused on neuropathic pain modulation and may also play a role in studying anxiety disorders. Its ability to regulate calcium influx makes it a significant compound for investigating therapeutic potentials in calcium-related pathophysiologies. -
Calcium Channel Inhibitor
(S)-Lercanidipine is a calcium channel blocker that exhibits antihypertensive and neuroprotective activities. It effectively reduces oxidative stress and has been shown to protect auditory sensory hair cells from noise-induced damage. In vitro studies demonstrate that (S)-Lercanidipine enhances cell viability, particularly at lower concentrations, and significantly lowers the hearing threshold in mice following noise exposure. Its antioxidant properties are characterized by an increase in the expression of antioxidant enzyme genes and a decrease in oxidative enzyme gene expression, suggesting its potential for mitigating noise-induced hearing loss and preserving outer hair cell viability. -
Cavα2δ1/NET Inhibitor
Cavα2δ1&NET-IN-1 is a dual inhibitor targeting the α2δ-1 subunit of voltage-gated calcium channels and the norepinephrine transporter (NET). This compound demonstrates inhibition of Cavα2δ-1 with a Ki value of 112 nM, and inhibits NET with a Ki of 383 nM and an IC50 of 67 nM. Cavα2δ1&NET-IN-1 is suitable for research applications focused on pain mechanisms and related therapeutic pathways. -
Calcium Channel Inhibitor
Cav 3.2 inhibitor 2 is a selective inhibitor of Cav3.2 T-type Ca2+ channels, exhibiting an IC50 of 0.09339 μM under a -80 mV holding potential. This compound effectively reduces T-channel-dependent somatic and visceral pain in murine models, making it a valuable tool for investigating intractable pain mechanisms. Its ability to modulate calcium channel activity positions Cav 3.2 inhibitor 2 as a significant agent in pain research and therapeutic development. -
Calcium Channel Inhibitor
Pincainide is a calcium channel inhibitor that specifically targets voltage-gated calcium channels in smooth muscle. It effectively reduces calcium influx, leading to the inhibition of norepinephrine- and high potassium-induced contractile responses. Pincainide is relevant in the study of cardiovascular diseases, providing insights into mechanisms related to smooth muscle function and regulation. -
Cavα2δ1/NET Inhibitor
Cavα2δ1&NET-IN-3 is a selective inhibitor targeting the α2δ subunit of voltage-gated calcium channels (VGCC) and the noradrenaline transporter (NET). This compound exhibits inhibitory constants (Kis) in the range of 100-500 nM for the human α2δ-1 subunit of the Cav2.2 calcium channel and for NET. Cavα2δ1&NET-IN-3 is utilized in research applications focused on pain modulation and neurotransmitter regulation, contributing to the understanding of various neurological disorders. -
Calcium Channel inhibitor
Calcium Channel Antagonist 4 is a potent inhibitor of voltage-gated calcium channels, exhibiting an IC50 value within the range of 5-20 μM. This compound's ability to selectively block calcium influx makes it a valuable tool for studying calcium signaling pathways in various cellular processes. It is particularly useful in research applications related to neurology, cardiology, and muscle physiology. -
SERCA Inhibitor
CXL 017 is a selective inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), functioning by competing with ATP for binding and thereby inhibiting ATPase activity. This compound demonstrates notable cytotoxicity specifically against multidrug-resistant acute myeloid leukemia cells, such as HL60/MX2. CXL 017 is valuable in research related to multidrug-resistant acute myeloid leukemia and offers insights into potential therapeutic approaches for overcoming drug resistance in cancer. -
Calcium Channel Inhibitor
A-1048400 is a selective calcium channel inhibitor that demonstrates potent activity against N-type and T-type calcium channels, with IC50 values of 1.4 μM and 1.2 μM, respectively. By inhibiting neurotransmitter release and reducing membrane hyperexcitability, A-1048400 exhibits significant analgesic properties. This compound is particularly valuable for investigating mechanisms and treatments related to neuropathic pain, such as that resulting from spinal nerve ligation and chronic constriction injury. -
Cav3.2 Inhibitor
Cav 3.2 inhibitor 3 is a selective inhibitor of the Cav3.2 T-type calcium channel, exhibiting an IC50 of 0.1534 μM. This compound demonstrates minimal binding affinity for D2 receptors, making it a valuable tool for studying the role of Cav3.2 channels in various physiological processes. Its use is particularly relevant in research areas focused on neuronal excitability and pain modulation. -
Calcium Channel Inhibitor
TTA-P1 is a potent inhibitor of human T-type calcium channels, exhibiting state-independent characteristics. This compound is crucial for studying various physiological processes such as neuronal burst firing, hormone secretion, and cell proliferation. TTA-P1 is particularly valuable for research related to absence epilepsy and other neurological disorders linked to calcium signaling. -
Calcium Channel Inhibitor
Agelenin is a polypeptide composed of 35 amino acids, functioning primarily as a calcium channel inhibitor. Isolated from the Agelena opulenta spider, this compound exhibits structural similarity to insect-specific calcium channel inhibitors, making it a valuable tool for studying calcium signaling pathways. Research applications include investigations into neuromuscular transmission and calcium-dependent cellular processes. -
L-/T-type Calcium Channel Inhibitor
HM12 is a covalent inhibitor targeting L-/T-type calcium channels, specifically Cav1.2 and Cav3.2, while demonstrating selectivity for N-type channels. This compound induces irreversible inhibition that remains effective post-washout, making it a valuable tool for investigating calcium channel dynamics. HM12 is applicable in research focused on various diseases, including hypertension, pain, and epilepsy, facilitating the exploration of calcium channel modulation in therapeutic contexts. -
Auxin Transport Inhibitor
3,4,5-Triiodobenzoic acid is an auxin transport inhibitor that modulates auxin distribution in plant systems. This compound enhances specific [3H]verapamil binding in zucchini microsomes and rabbit skeletal muscle membranes, highlighting its potential role in studying calcium channel interactions. 3,4,5-Triiodobenzoic acid is valuable for research focused on smooth muscle contraction and the biochemical pathways influencing plant hormone transport. -
Ca2+ Channel Inhibitor
Ethaverine hydrochloride is a potent inhibitor of L-type calcium channels, primarily affecting cardiac tissues. It serves as a peripheral vasodilator and antispasmodic agent, demonstrating significant biological activity in relaxing smooth muscle. This compound is commonly utilized in research related to peripheral vascular disease and its associated disorders.
