Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, demonstrating potent activity against Gram-positive, Gram-negative, and anaerobic pathogens. Additionally, it serves as a selective and orally active inhibitor of the pannexin 1 channel (PANX1), with an IC50 of 4 μM for PANX1 inward current. Unlike other channels, Trovafloxacin mesylate does not affect connexin 43 gap junctions or PANX2, leading to potential therapeutic applications in the regulation of apoptosis by disrupting normal fragmentation of apoptotic cells through PANX1 inhibition.
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, demonstrating potent activity against Gram-positive, Gram-negative, and anaerobic pathogens. Additionally, it serves as a selective and orally active inhibitor of the pannexin 1 channel (PANX1), with an IC50 of 4 μM for PANX1 inward current. Unlike other channels, Trovafloxacin mesylate does not affect connexin 43 gap junctions or PANX2, leading to potential therapeutic applications in the regulation of apoptosis by disrupting normal fragmentation of apoptotic cells through PANX1 inhibition.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
