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Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Targets
| Target | Value |
|---|---|
| HDAC6 | IC50: 15nM |
| HDAC8 | IC50: 854nM |
| HDAC1 | IC50: 16.4μM |
| HDAC2 | IC50: >30μM |
| HDAC3 | IC50: >30μM |
| HDAC4 | IC50: >30μM |
| HDAC5 | IC50: >30μM |
| HDAC7 | IC50: >30μM |
| HDAC9 | IC50: >30μM |
| HDAC10 | IC50: >30μM |
| HDAC11 | IC50: >30μM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.89 mL | 134.44 mL | 268.89 mL |
| 0.5 mM | 5.38 mL | 26.89 mL | 53.78 mL |
| 1 mM | 2.69 mL | 13.44 mL | 26.89 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
*The above data is based on the productmolecular weight 371.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A11042 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 371.9 |
| Formula | C20H21N3O2.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1310693-92-5, 1239262-52-2 |
| Synonyms | N/A |
| SMILES | CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl |
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