Tubastatin A HCl

Catalog No.: A11042

HDAC6 inhibitor

Tubastatin A HCl

Tubastatin A HCl Chemical Structure

CAS NO. 1310693-92-5, 1239262-52-2

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$80.00
50 mg
$90.00
100 mg
$150.00
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Biological Activity

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
Targets
Target Value
HDAC6IC50: 15nM
HDAC8IC50: 854nM
HDAC1IC50: 16.4μM
HDAC2IC50: >30μM
HDAC3IC50: >30μM
HDAC4IC50: >30μM
HDAC5IC50: >30μM
HDAC7IC50: >30μM
HDAC9IC50: >30μM
HDAC10IC50: >30μM
HDAC11IC50: >30μM
In vitro (25°C) DMSO 67 mg/mL (180.17 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 5.2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.89 mL 134.44 mL 268.89 mL
0.5 mM 5.38 mL 26.89 mL 53.78 mL
1 mM 2.69 mL 13.44 mL 26.89 mL
5 mM 0.54 mL 2.69 mL 5.38 mL

*The above data is based on the productmolecular weight 371.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11042
Actions Inhibitor
CAS No. 1310693-92-5, 1239262-52-2
Formula C20H21N3O2.HCl
M. Wt 371.9
Purity >98%
SMILES CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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