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ATM/ATR inhibitor

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Catalog No. A11605

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VE-821 10mg A11605-10

Regular Price: €104.50

Special Price: €94.05

VE-821 25mg A11605-25

Regular Price: €190.00

Special Price: €171.00

VE-821 50mg A11605-50

Regular Price: €332.50

Special Price: €299.25

VE-821 10mM * 1mL in DMSO A11605-10mM-D

Regular Price: €76.00

Special Price: €68.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VE-821 is a potent and selective inhibitor of protein kinase ATR.


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Publications citing Adooq Products
VE-821 Citations (5)
  • Mitsuru Sasaki-Honda, .et al. A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4, Hum Mol Genet, 2018, Dec 1; 27(23): 4024-4035 PMID: 30107443
  • Kim J, .et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions, Mol Cell, 2018, Jan 4;69(1):36-47.e7 PMID: 29249653
  • Antonio Postigo, .et al. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication, Cell Rep, 2017, May 2; 19(5): 1022-1032 PMID: 28467896
  • Nnennaya Kanu, .et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer, Genome Biol, 2016, 17: 185 PMID: 27634334
  • Carolyn Botting, .et al. H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication, Virol J, 2016, 13: 15 PMID: 26817608

Chemical Information

Catalog Num A11605
Actions Inhibitor
M. Wt 468.4
Formula C18H16N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1232410-49-9
Synonyms VE821

Biological Activity

VE-821 is a potent and selective inhibitor of protein kinase ATR.
ATR (Cell-free assay)
13 nM(Ki)


Solubility (25°C) * In vitro DMSO 74 mg/mL (200.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.35 mL 106.75 mL 213.49mL
0.5 mM 4.27 mL 21.35 mL 42.7 mL
1 mM 2.13 mL 10.67 mL 21.35 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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