VE-821

Catalog No.: A11605

ATM/ATR inhibitor

VE-821

VE-821 Chemical Structure

CAS NO. 1232410-49-9

VE-821 is a potent and selective inhibitor of protein kinase ATR.

Availability: In stock

Package Price Qty
10 mg
$110.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$80.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Mitsuru Sasaki-Honda, .et al. A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4, Hum Mol Genet, 2018, Dec 1; 27(23): 4024-4035 PMID: 30107443
  • Kim J, .et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions, Mol Cell, 2018, Jan 4;69(1):36-47.e7 PMID: 29249653
  • Antonio Postigo, .et al. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication, Cell Rep, 2017, May 2; 19(5): 1022-1032 PMID: 28467896
  • Nnennaya Kanu, .et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer, Genome Biol, 2016, 17: 185 PMID: 27634334
  • Carolyn Botting, .et al. H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication, Virol J, 2016, 13: 15 PMID: 26817608

Biological Activity

VE-821 is a potent and selective inhibitor of protein kinase ATR.
Targets
ATR (Cell-free assay)
13 nM(Ki)
In vitro (25°C) DMSO 74 mg/mL (200.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.35 mL 106.75 mL 213.49 mL
0.5 mM 4.27 mL 21.35 mL 42.7 mL
1 mM 2.13 mL 10.67 mL 21.35 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11605
Actions Inhibitor
M. Wt 468.4
Formula C18H16N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1232410-49-9
Synonyms VE821
SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N

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