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- Mitsuru Sasaki-Honda, .et al. A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4, Hum Mol Genet, 2018, Dec 1; 27(23): 4024-4035 PMID: 30107443
- Kim J, .et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions, Mol Cell, 2018, Jan 4;69(1):36-47.e7 PMID: 29249653
- Antonio Postigo, .et al. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication, Cell Rep, 2017, May 2; 19(5): 1022-1032 PMID: 28467896
- Nnennaya Kanu, .et al. DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer, Genome Biol, 2016, 17: 185 PMID: 27634334
- Carolyn Botting, .et al. H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication, Virol J, 2016, 13: 15 PMID: 26817608
Biological Activity
VE-821 is a potent and selective inhibitor of protein kinase ATR.
Targets
ATR (Cell-free assay) | ||||
13 nM(Ki) |
In vitro (25°C) | DMSO | 65 mg/mL (176.43 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.14 mL | 135.72 mL | 271.44 mL |
0.5 mM | 5.43 mL | 27.14 mL | 54.29 mL |
1 mM | 2.71 mL | 13.57 mL | 27.14 mL |
5 mM | 0.54 mL | 2.71 mL | 5.43 mL |
*The above data is based on the productmolecular weight 368.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11605 |
---|---|
Actions | Inhibitor |
CAS No. | 1232410-49-9 |
Formula | C18H16N4O3S |
M. Wt | 368.4 |
Purity | >98% |
Synonyms | VE821 |
SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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