Venturicidin A is a macrolide antibiotic that acts as a potent inhibitor of ATP synthase. Derived from actinomycetes, it enhances the efficacy of the aminoglycoside antibiotic gentamicin against multidrug-resistant strains of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Although Venturicidin A demonstrates significant antibacterial activity, it also exhibits notable toxicity towards human embryonic kidney (HEK) cells, with an IC50 value of 31 μg/mL, making it a valuable compound for research in antibiotic resistance and cellular response assessments.
Venturicidin A is a macrolide antibiotic that acts as a potent inhibitor of ATP synthase. Derived from actinomycetes, it enhances the efficacy of the aminoglycoside antibiotic gentamicin against multidrug-resistant strains of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Although Venturicidin A demonstrates significant antibacterial activity, it also exhibits notable toxicity towards human embryonic kidney (HEK) cells, with an IC50 value of 31 μg/mL, making it a valuable compound for research in antibiotic resistance and cellular response assessments.
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