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Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
Targets
| HDAC (Cell-free assay) | ||||
| ~10 nM |
| In vitro (25°C) | DMSO | 53 mg/mL (200.52 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 3 mg/mL (11.35 mM) | ||
| In vivo | 2% DMSO, 40% PEG 300, 5% propylene glycol, 1% Tween 80 | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.84 mL | 189.18 mL | 378.36 mL |
| 0.5 mM | 7.57 mL | 37.84 mL | 75.67 mL |
| 1 mM | 3.78 mL | 18.92 mL | 37.84 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10979 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 264.3 |
| Formula | C14H20N2O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 149647-78-9 |
| Synonyms | Zolinza, MK-0683 |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
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