Vorinostat (SAHA)

Catalog No.: A10979

HDAC inhibitor

Vorinostat (SAHA)

Vorinostat (SAHA) Chemical Structure

CAS NO. 149647-78-9

Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.

Availability: In stock

Package Price Qty
200 mg
$45.00
500 mg
$95.00
10mM * 1mL in DMSO
$60.00
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  • Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
  • David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
  • Arshdeep Singh, .et al. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition, Eur J Med Chem, 2021, Apr 5;215:113169 PMID: 33588178
  • Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
  • Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14

Biological Activity

Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
Targets
HDAC (Cell-free assay)
~10 nM
In vitro (25°C) DMSO 49 mg/mL (185.39 mM)
Water Insoluble
Ethanol 3 mg/mL (11.35 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.84 mL 189.18 mL 378.36 mL
0.5 mM 7.57 mL 37.84 mL 75.67 mL
1 mM 3.78 mL 18.92 mL 37.84 mL
5 mM 0.76 mL 3.78 mL 7.57 mL

*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10979
Actions Inhibitor
CAS No. 149647-78-9
Formula C14H20N2O3
M. Wt 264.3
Purity >98%
Synonyms Zolinza, MK-0683
SMILES C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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