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$0.00 - Ting-Yu Chang, .et al. A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling, Biomed Pharmacother, 2021, Jun;138:111485 PMID: 33740521
- David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
- Arshdeep Singh, .et al. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition, Eur J Med Chem, 2021, Apr 5;215:113169 PMID: 33588178
- Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
- Giovanni Bocci, .et al. Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19, ACS Pharmacol Transl Sci, 2020, Oct 14
Biological Activity
Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
Targets
| HDAC (Cell-free assay) | ||||
| ~10 nM |
| In vitro (25°C) | DMSO | 49 mg/mL (185.39 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (11.35 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 37.84 mL | 189.18 mL | 378.36 mL |
| 0.5 mM | 7.57 mL | 37.84 mL | 75.67 mL |
| 1 mM | 3.78 mL | 18.92 mL | 37.84 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10979 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 149647-78-9 |
| Formula | C14H20N2O3 |
| M. Wt | 264.3 |
| Purity | >98% |
| Synonyms | Zolinza, MK-0683 |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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Contact information
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