Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
Giovanni Bocci, .et al. , ACS Pharmacol Transl Sci, 2020, Oct 14
Biological Activity
Discription
Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.
Targets
Target
Value
Chemical Information
Catalog Num
A10979
Formula
C14H20N2O3
Molecular Weight
264.3
CAS Number
149647-78-9
SMILES
C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
Synonyms
Zolinza, MK-0683
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro (25°C)
DMSO
49 mg/mL (185.39 mM)
Water
Insoluble
Ethanol
3 mg/mL (11.35 mM)
In vivo
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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