XP5 is a potent, orally active inhibitor of HDAC6, exhibiting an IC50 of 31 nM. This compound demonstrates significant antiproliferative activity across various cancer cell lines, including those exhibiting resistance to HDAC inhibitors such as YCC3/7 gastric cancer cells (IC50 = 0.16-2.31 μM). Furthermore, XP5 has been shown to enhance antitumor immunity when used in conjunction with a PD-L1 inhibitor in melanoma research applications.
XP5 is a potent, orally active inhibitor of HDAC6, exhibiting an IC50 of 31 nM. This compound demonstrates significant antiproliferative activity across various cancer cell lines, including those exhibiting resistance to HDAC inhibitors such as YCC3/7 gastric cancer cells (IC50 = 0.16-2.31 μM). Furthermore, XP5 has been shown to enhance antitumor immunity when used in conjunction with a PD-L1 inhibitor in melanoma research applications.
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