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Catalog No.: A11174

γ-secretase inhibitor


YO-01027 Chemical Structure

CAS NO. 209984-56-5

YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.

Availability: In stock

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5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Biological Activity

YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
γ secretase(APPL) (Cell-free assay) γ secretase(Notch) (Cell-free assay)
2.6 nM2.9 nM
In vitro (25°C) DMSO 87 mg/mL (187.7 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% hydroxyethyl cellulose 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.58 mL 107.88 mL 215.76 mL
0.5 mM 4.32 mL 21.58 mL 43.15 mL
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11174
Actions Inhibitor
CAS No. 209984-56-5
Formula C26H23F2N3O3
M. Wt 463.48
Purity >98%
Synonyms YO01027, Dibenzazepine, Deshydroxy LY 411575
SMILES C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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