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Biological Activity
YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
Targets
| γ secretase(APPL) (Cell-free assay) | γ secretase(Notch) (Cell-free assay) | |||
| 2.6 nM | 2.9 nM |
| In vitro (25°C) | DMSO | 87 mg/mL (187.7 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% hydroxyethyl cellulose | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.58 mL | 107.88 mL | 215.76 mL |
| 0.5 mM | 4.32 mL | 21.58 mL | 43.15 mL |
| 1 mM | 2.16 mL | 10.79 mL | 21.58 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
*The above data is based on the productmolecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11174 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 209984-56-5 |
| Formula | C26H23F2N3O3 |
| M. Wt | 463.48 |
| Purity | >98% |
| Synonyms | YO01027, Dibenzazepine, Deshydroxy LY 411575 |
| SMILES | C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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