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PI3K inhibitor

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Catalog No. A11161

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Product Name Catalog No. Price Qty
Wortmannin 5mg A11161-5

Regular Price: $80.00

Special Price: $64.00

Wortmannin 10mg A11161-10

Regular Price: $110.00

Special Price: $88.00

Wortmannin 25mg A11161-25

Regular Price: $240.00

Special Price: $192.00

Wortmannin 50mg A11161-50

Regular Price: $380.00

Special Price: $304.00

Wortmannin 10mM * 1mL in DMSO A11161-10mM-D

Regular Price: $85.00

Special Price: $68.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).


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Chemical Information

Catalog Num A11161
Actions Inhibitor
M. Wt 428.43
Formula C23H24O8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 19545-26-7
Synonyms SL-2052
SMILES code CC(=O)O[[email protected]@H]1C[[email protected]]2([[email protected]@H](CCC2=O)C3=C1[[email protected]]4([[email protected]](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Chemical Name (1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11 b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-f uro[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6, 9-trione

Biological Activity


Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

PI3K (Cell-free assay) DNA-PK [12](Cell-free assay) ATM [12](Cell-free assay) MLCK (Cell-free assay) ATR [12](Cell-free assay)
3 nM16 nM150 nM170 nM1.8 μM


Solubility (25°C) * In vitro DMSO 86 mg/mL (200.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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