Wortmannin Chemical Structure

CAS NO. 19545-26-7

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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Package Price Qty
5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $110.00

Special Price $88.00

25 mg

Regular Price: $240.00

Special Price $192.00

50 mg

Regular Price: $380.00

Special Price $304.00

10mM * 1mL in DMSO
$85.00
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Biological Activity

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

Targets
PI3K (Cell-free assay) DNA-PK [12](Cell-free assay) ATM [12](Cell-free assay) MLCK (Cell-free assay) ATR [12](Cell-free assay)
3 nM16 nM150 nM170 nM1.8 μM
In vitro (25°C) DMSO 86 mg/mL (200.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.71 mL 233.41 mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11161
Actions Inhibitor
M. Wt 428.43
Formula C23H24O8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 19545-26-7
Synonyms SL-2052
SMILES CC(=O)O[[email protected]@H]1C[[email protected]]2([[email protected]@H](CCC2=O)C3=C1[[email protected]]4([[email protected]](OC(=O)C5=COC(=C54)C3=O)COC)C)C

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