Anti-inflammatory agent 56 is a selective COX-2 inhibitor with an IC50 of 0.54 μM. It demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing oxidative stress-induced cell death. By inhibiting key targets such as Keap1, COX-2, and iNOS, this compound mitigates neuroinflammation and oxidative stress. Furthermore, it exhibits low acute toxicity in murine models, with an LD50 of 1000 mg/kg, making it a valuable tool for research in inflammation and neuroprotection.
Anti-inflammatory agent 56 is a selective COX-2 inhibitor with an IC50 of 0.54 μM. It demonstrates significant anti-inflammatory and antioxidant properties, effectively reducing oxidative stress-induced cell death. By inhibiting key targets such as Keap1, COX-2, and iNOS, this compound mitigates neuroinflammation and oxidative stress. Furthermore, it exhibits low acute toxicity in murine models, with an LD50 of 1000 mg/kg, making it a valuable tool for research in inflammation and neuroprotection.
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