ADC Linker

Propargyl-PEG4-Br is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs, facilitating effective targeted delivery of therapeutic agents. This non-cleavable linker integrates an alkyne group, enabling its application in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Propargyl-PEG4-Br is essential for the synthesis of advanced bioconjugates to enhance therapeutic efficacy and specificity in research applications.

Propargyl-C2-NHS ester is a non-cleavable linker designed for antibody-drug conjugation (ADC) applications. This compound features an alkyne functional group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its stability and efficiency make it an essential tool for researchers developing targeted therapies through ADC technology.

m-PEG12-amine is a polyethylene glycol (PEG)-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This non-cleavable 12-unit PEG linker enhances the stability and solubility of ADCs, facilitating targeted delivery of therapeutic agents. Its application in PROTAC development aids in the effective degradation of specific target proteins, thus advancing research in targeted protein modulation and therapeutic interventions.

Amino-Tri-(carboxyethoxymethyl)-methane is a versatile cleavable PEG linker designed for the synthesis of antibody-drug conjugates (ADCs). Its unique structure facilitates controlled release of cytotoxic agents, enhancing the therapeutic efficacy of ADCs. Additionally, this compound serves as a PEG-based linker for the development of PROTACs, providing optimized performance in targeted protein degradation research applications.

N3-Ph-NHS ester is a non-cleavable linker for antibody-drug conjugates (ADCs), designed to facilitate the synthesis of these complex bioconjugates. As a click chemistry reagent, it features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biologists engaged in ADC development.

Fmoc-NH-PEG1-CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This PEG-based compound facilitates the construction of ADCs by linking antibodies to cytotoxic agents while ensuring controlled release. Additionally, it serves as a versatile linker in the development of PROTACs, enabling effective targeted protein degradation for various research applications in drug discovery and development.

Azido-methyltetrazine di-arm linker is a novel linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This multivalent linker facilitates the conjugation of therapeutic agents to antibodies, enhancing the efficacy and targeting capabilities of ADCs. It is an essential reagent for researchers exploring the development of targeted cancer therapies and improving the selectivity of drug delivery systems.

DBCO-PEG4-amine is a PEG-based linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This versatile cleavable linker allows for efficient conjugation through its DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its applications extend to the creation of homobifunctional cross-linkers, such as FPM-PEG4-DBCO, facilitating advanced drug delivery and targeted degradation strategies in chemical biology research.

Azido-PEG9-amine is a non-cleavable linker comprising a 9-unit polyethylene glycol (PEG) chain, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This versatile reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it suitable for applications in PROTAC synthesis and click chemistry.

1-Cbz-azetidine-3-carboxylic acid serves as a non-cleavable linker for antibody-drug conjugates (ADCs), enabling the targeted delivery of therapeutics to specific cells. This compound is also employed as an alkyl chain-based linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating protein degradation pathways in research applications. Its versatile functionality makes it a valuable tool in bioconjugation and targeted therapy research.

m-PEG6-NHS ester is a non-cleavable linker designed for applications in PROTAC synthesis. This 6-unit polyethylene glycol (PEG) linker plays a crucial role in the construction of antibody-drug conjugates (ADCs), enabling effective cellular delivery of therapeutic agents. Its unique structure facilitates the conjugation of various biomolecules, making it a valuable tool for researchers in the fields of targeted drug delivery and protein degradation studies.

(2R,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is a non-cleavable linker for antibody-drug conjugates (ADCs). This compound facilitates the synthesis of ADCs by providing a stable connection between the antibody and the cytotoxic agent. Additionally, it serves as a suitable linker in the development of PROTACs, enhancing the design of targeted protein degradation strategies in biochemical research.

BCN-exo-PEG7-maleimide is an ADC linker featuring a polyethylene glycol (PEG) spacer of seven units, facilitating improved solubility and stability. This compound incorporates the bidentate macrocyclic ligand BCN, enabling efficient synthesis of macrocyclic complexes. In click chemistry applications, BCN selectively reacts with azide-containing molecules to yield stable triazoles without the need for catalysts. Additionally, the maleimide functional group undergoes hydrolytic degradation, making it suitable for drug delivery research.

Fmoc-Gly-NH-CH2-O-Cyclopropane-CH2COOH is an ADC linker intermediate that facilitates the conjugation of cytotoxic agents to antibodies. This compound features a benzyl 2-cyclopropyl-2-hydroxyacetate moiety and is designed for use in the synthesis of antibody-drug conjugates (ADCs), enhancing the therapeutic potential of targeted cancer treatments. It is suitable for research applications in the development of ADCs, including those involving agents such as Exatecan.

H-(Gly)3-Lys(N3)-OH hydrochloride is a versatile click chemistry reagent featuring an azide group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. This compound also supports ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-modified substrates. Its high yield, specificity, and simplicity make it suitable for various research applications, including the labeling and functionalization of nucleic acids, lipids, and proteins, thereby facilitating advanced studies in chemical biology and bioconjugation.

Cy5.5 DBCO is a cycloalkyne-based click chemistry reagent featuring a cyanine 5.5 fluorophore. The presence of the DBCO moiety facilitates copper-free, biocompatible click reactions characterized by rapid kinetics and enhanced stability. This reagent is widely utilized in bioconjugation applications, enabling efficient labeling of biomolecules for imaging and detection in various biological studies.

Bis-PEG1-NHS ester is a non-cleavable linker designed for antibody-drug conjugation (ADC) applications. This 1-unit polyethylene glycol (PEG) linker enhances the solubility and stability of conjugates while maintaining effective targeting. It is utilized in the development of ADCs to improve therapeutic efficacy and minimize off-target effects, making it a valuable tool in bioconjugation research.

Val-Cit is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates the selective release of cytotoxic drugs upon internalization, enhancing the therapeutic efficacy of ADCs. This compound is pivotal in cancer research, enabling the targeted delivery of therapeutics to malignant cells while minimizing systemic toxicity.

Tetrazine-SS-Biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a Tetrazine moiety, it facilitates the inverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) derivatives. This unique reactivity enables precise targeting and controlled release of therapeutic agents, making it valuable in cancer research and the development of targeted therapies.

Propargyl-PEG5-NHS ester is a cleavable linker primarily used in the synthesis of antibody-drug conjugates (ADCs) and PROTAC molecules. This PEG/alkyl/ether-based compound features an alkyne functionality, facilitating click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing partners. Its versatility makes it suitable for various applications in targeted protein degradation and the development of ADCs, supporting advanced research in drug delivery and molecular biology.

Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and efficiently functions as a PEG-based PROTAC linker. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity positions Azido-PEG5-CH2CO2H as a valuable tool in chemical biology, particularly in targeted therapeutics and drug delivery systems.

(2-pyridyldithio)-PEG1-hydrazine is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent facilitates the attachment of therapeutic agents to antibodies, ensuring selective delivery to target cells. Its PEGylated structure enhances solubility and stability, making it suitable for various bioconjugation applications in drug development and cancer research.

Mc-Val-Ala-PAB is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates targeted drug delivery by enabling the release of cytotoxic agents upon internalization and cleavage within target cells. Its application in ADC development enhances the therapeutic potential and specificity of anticancer therapies.

Bromoacetamido-PEG4-acid is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound exhibits crucial properties for the development of targeted protein degradation strategies. In addition, it serves as a cleavable linker in antibody-drug conjugate (ADC) technology, facilitating the conjugation of therapeutic agents to antibodies for improved specificity and efficacy in cancer treatment. Its versatile applications make it essential for advancements in targeted therapies and drug delivery systems.

MC-Ala-Ala-PAB is a cleavable linker specifically designed for use in antibody-drug conjugates (ADCs). This reagent facilitates the conjugation of therapeutic agents to antibodies, enabling targeted delivery in cancer research. Its ability to cleave in specific environments enhances the release of the drug in targeted tissues, which is critical for maximizing therapeutic efficacy and minimizing off-target effects.

Biotin-TEG-ATFBA is a click chemistry reagent featuring a perfluorophenylazide moiety. This compound is known for forming a highly stable azene intermediate, facilitating insertion and addition reactions with moderate to good yields following photolysis. It possesses an azide functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Biotin-TEG-ATFBA can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-tagged substrates, making it a valuable tool for bioconjugation and labeling applications in chemical biology.

Br-PEG4-C2-Boc is a cleavable 4-unit polyethylene glycol (PEG) linker specifically designed for use in antibody-drug conjugates (ADCs). This reagent facilitates the conjugation of drugs to antibodies, enabling targeted delivery and enhanced therapeutic efficacy. Its versatile chemical structure allows for efficient drug release in response to specific cleavage mechanisms, making it suitable for research applications in ADC development and optimization.

Fmoc-NH-PEG8-CH2COOH is a cleavable linker optimized for antibody-drug conjugates (ADCs) and serves as a PEG-based linker for PROTAC synthesis. This compound facilitates effective conjugation of biomolecules while enabling targeted degradation of specific proteins, making it essential for drug development and therapeutic research. Its application spans the design of innovative ADCs and the advancement of PROTAC technology in cellular studies.

22-(tert-Butoxy)-22-oxodocosanoic acid serves as a non-cleavable linker for antibody-drug conjugates (ADCs), facilitating the stable attachment of cytotoxic agents to antibodies. This compound is integral for enhancing the therapeutic efficacy of ADCs by ensuring a robust conjugation without premature release. Additionally, it functions as an alkyl chain-based PROTAC linker, enabling targeted protein degradation applications in chemical biology research.

DBCO-PEG2-DBCO is a versatile click chemistry reagent featuring two terminal dibenzocyclooctyne (DBCO) groups connected by a polyethylene glycol (PEG) linker. This compound is engineered for efficient, copper-free click reactions, making it particularly valuable in the development of antibody-drug conjugates (ADCs). Its unique chemical properties promote strong and selective labeling, enabling researchers to explore novel therapeutic applications and enhance drug delivery systems in biomedical research. This reagent is intended for research use only.

NHS-SS-biotin is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features an N-hydroxysuccinimide (NHS) ester that facilitates efficient conjugation to amino groups on antibodies, while its disulfide bond allows for controlled release of the drug upon internalization. NHS-SS-biotin is crucial for applications in targeted therapy research and the development of novel ADC formulations.

N-Boc-diethanolamine is a cleavable linker based on an alkyl/ether structure, primarily utilized in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound facilitates the conjugation of therapeutic agents to antibodies, enhancing targeted delivery and efficacy. Its application in PROTAC technology allows for the selective degradation of target proteins, making it a valuable tool in drug discovery and development.

N3Ac-OPhOMe is an azide-containing click chemistry reagent that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC). Its utility in conjugating biomolecules allows for diverse applications in biochemical research, including the labeling and tracking of proteins, nucleic acids, and complex biomolecular interactions. This compound serves as a valuable tool in chemical biology and biomaterials development.

Fmoc-Val-Ala-aminomethyl acetate is a versatile ADC linker that facilitates the synthesis of antibody-drug conjugates (ADCs). This compound plays a crucial role in enhancing the stability and efficacy of conjugated therapeutics. It is essential for researchers developing targeted therapies in cancer and other diseases, providing a means for precise drug delivery.

BCN-PEG3-OH is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. As a click chemistry reagent, it features a bicyclo[6.1.0]nonyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound supports robust conjugation strategies, enhancing the delivery of cytotoxic agents in targeted cancer therapies. Its efficiency makes it an invaluable tool in the development of ADCs for various research applications.

SPDMV is a glutathione-cleavable linker utilized in antibody-drug conjugate (ADC) applications. It promotes the targeted release of cytotoxic agents upon intracellular reduction, enhancing therapeutic efficacy and minimizing off-target effects. SPDMV is ideal for research focused on the development and optimization of ADCs in cancer therapy.

Fmoc-Lys-OH hydrochloride is a cleavable linker for antibody-drug conjugates (ADCs), facilitating targeted delivery of cytotoxic agents to cancer cells. This compound is instrumental in the synthesis of ADCs, providing a functional group for conjugation. Additionally, Fmoc-Lys-OH hydrochloride serves as an alkyl chain-based linker in the development of PROTACs, enhancing selective protein degradation pathways for therapeutic applications.

Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable linker utilized in the development of antibody-drug conjugates (ADCs), demonstrating significant versatility in chemical synthesis. This alkyl chain-based compound serves as a valuable PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). Its structured design enhances the efficiency of targeted protein degradation, making it an essential tool for researchers in the field of drug discovery and therapeutic development.

N3-C4-NHS ester is a noncleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), specifically targeting azide groups. This compound facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, enabling efficient conjugation. Additionally, N3-C4-NHS ester can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it highly versatile for bioconjugation applications in chemical biology and therapeutic development.

Biotin-PEG4-PFP ester is a cleavable linker designed for use in PROTAC (Proteolysis Targeting Chimera) technology, facilitating the synthesis of antibody-drug conjugates (ADCs). This 4 unit PEG linker enhances solubility and stability, which are vital for effective drug delivery. Its unique structure enables selective conjugation while maintaining biological activity, making it an essential tool for researchers developing targeted therapies in cancer and other disease models.

m-PEG12-OH is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This non-cleavable linker consists of a 12-unit polyethylene glycol chain, facilitating stable conjugation in bioconjugation applications. Its properties enable efficient delivery of biologically active drugs to target cells, making it suitable for research in targeted therapy and drug development.

PC Biotin-PEG3-NHS ester is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This highly soluble pegylated compound allows for efficient conjugation to antibodies, enhancing stability and facilitating targeted delivery of cytotoxic agents. Its primary applications include the development of ADCs for cancer therapeutics and research into targeted treatment strategies.

MC-AAA-NHCH2OCH2COOH is a cleavable linker designed for use in antibody-drug conjugates (ADCs). This compound facilitates the targeted delivery of cytotoxic agents to specific cells, enhancing therapeutic efficacy while minimizing off-target effects. Its unique structure enables effective release of the drug payload in the tumor microenvironment, making it suitable for various oncology research applications.

2-Azidoethyl β-D-lactoside is a versatile click chemistry reagent designed for the selective conjugation of biomolecules. It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, offering high efficiency and specificity. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives. This reagent is useful in various biological research applications, including the labeling and tracking of nucleic acids, proteins, and lipids within complex biological systems.

Propargyl-PEG5-acid is a non-cleavable polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) applications. It facilitates the synthesis of ADCs targeting Galectin-3 and serves as a versatile PROTAC linker. This compound features an alkyne functional group that enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool for click chemistry in chemical biology research. Researchers can utilize Propargyl-PEG5-acid in various applications, including drug conjugation and the development of therapeutic agents.

Propargyl-Tos is a cleavable linkers designed for use in the synthesis of antibody-drug conjugates (ADCs). Featuring an alkyne group, Propargyl-Tos facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This property makes it valuable for constructing complex bioconjugates, enhancing the therapeutic efficacy of ADCs in targeted cancer therapy research.

Mal-NH-ethyl-SS-propionic acid is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). This compound facilitates the selective release of the cytotoxic drug upon internalization, enhancing therapeutic efficacy. Its application in ADC development enables targeted delivery of therapeutic agents, making it valuable in various cancer research studies and the advancement of targeted therapies.

Mal-PEG1-Val-Cit-PABC-OH is a cleavable polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the attachment of cytotoxic agents to antibodies while maintaining stability in circulation. Upon reaching the target site, the linker can be cleaved, releasing the therapeutic payload and enhancing cytotoxic efficacy. This compound is valuable for research applications focusing on ADC development and optimization.

Tr-PEG2-OH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This non-cleavable linker, featuring a two-unit PEG structure, facilitates the development of antibody-drug conjugates (ADCs). Its key biological activity includes promoting targeted protein degradation and enhancing the solubility and pharmacokinetics of conjugated molecules, making it a valuable tool in chemical biology and therapeutic research applications.

Propargyl-PEG8-acid is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating the conjugation of azide-containing biomolecules. Its utility in creating cleavable linkers makes it valuable for targeted drug delivery applications, particularly against Gram-negative bacterial infections. This versatile reagent supports the development of innovative therapeutic strategies in chemical biology and drug discovery.