Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and efficiently functions as a PEG-based PROTAC linker. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity positions Azido-PEG5-CH2CO2H as a valuable tool in chemical biology, particularly in targeted therapeutics and drug delivery systems.
Azido-PEG5-CH2CO2H is a cleavable 5-unit PEG linker designed for use in the synthesis of antibody-drug conjugates (ADCs) and efficiently functions as a PEG-based PROTAC linker. This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity positions Azido-PEG5-CH2CO2H as a valuable tool in chemical biology, particularly in targeted therapeutics and drug delivery systems.
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