Catalog No.: A13652

IMPDH inhibitor


AVN-944 Chemical Structure

CAS NO. 297730-17-7

AVN-944 is an orally available, synthetic small molecule with potential antineoplastic activity.

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  • Desarey Morales Vasquez, .et al. Identification of Inhibitors of ZIKV Replication, Viruses, 2020, Sep; 12(9): 1041 PMID: 32961956
  • Park JG, .et al. Identification and characterization of novel compounds with broad spectrum antiviral activity against influenza A and B viruses, J Virol, 2020, Mar 17;94(7) PMID: 31941776
  • Dunham EC, .et al. Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses, Antiviral Res, 2018, Sep;157:140-150 PMID: 30031760

Biological Activity

AVN-944 is an orally available, synthetic small molecule with potential antineoplastic activity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.94 mL 104.71 mL 209.42 mL
0.5 mM 4.19 mL 20.94 mL 41.88 mL
1 mM 2.09 mL 10.47 mL 20.94 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13652
Actions Inhibitor
CAS No. 297730-17-7
Formula C25H27N5O5
M. Wt 477.51
Purity >98%
Synonyms AVN 944, AVN944, VX-944, VX 944, VX944
SMILES CC[[email protected]](CC#N)OC(=O)N[[email protected]@H](C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C3=CN=CO3)OC

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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