BCN-PEG4-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves the BCN group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for enabling targeted protein degradation and enhancing the therapeutic potential of PROTACs in chemical biology research. Additionally, it serves as an effective tool for bioconjugation applications, expanding the versatility of synthetic approaches in drug discovery.
BCN-PEG4-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves the BCN group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for enabling targeted protein degradation and enhancing the therapeutic potential of PROTACs in chemical biology research. Additionally, it serves as an effective tool for bioconjugation applications, expanding the versatility of synthetic approaches in drug discovery.
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