BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No.: A10133
PI3K/mTOR Inhibitor
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Research use only. We do not sell to patients.
Other Forms of BEZ235 (NVP-BEZ235, Dactolisib)
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Adooq Products cited in reputable paper
Adooq's BEZ235 (NVP-BEZ235, Dactolisib) has been cited by 5 publications
- Kohei Maruyama, .et al. , NPJ Precis Oncol, 2025, Jan 6;9(1):4 PMID: 39762482
- Lijuan Chen, .et al. , Behav Neurol, 2023, May 9;2023:6991826 PMID: 37200987
- Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
- Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
- Dominik Schulz, .et al. , Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902
Biological Activity
| Description | BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. | |||||
|---|---|---|---|---|---|---|
| Targets |
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| Cell Research |
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Product Information
| Catalog Num | A10133 |
|---|---|
| Formula | C30H23N5O |
| Molecular Weight | 469.6 |
| CAS Number | 915019-65-7 |
| SMILES | CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | <1 mg/mL | |
| Water | Insoluble | ||
| Ethanol | Warmed: 16 mg/mL (34.07 mM) | ||
| In vivo | NMP+PEG300 (10+90, v+v) | 28 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.29 mL | 106.47 mL | 212.95 mL |
| 0.5 mM | 4.26 mL | 21.29 mL | 42.59 mL |
| 1 mM | 2.13 mL | 10.65 mL | 21.29 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
