BEZ235 (NVP-BEZ235, Dactolisib)

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
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BEZ235 25mg
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Adooq Products cited in reputable paper
Adooq's BEZ235 (NVP-BEZ235, Dactolisib) has been cited by 4 publications
  • Lijuan Chen, .et al. , Behav Neurol, 2023, May 9;2023:6991826 PMID: 37200987
  • Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
  • Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Dominik Schulz, .et al. , Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902
  • Biological Activity
    Discription BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
    Target Value
    Product Information
    Catalog Num A10133
    Formula C30H23N5O
    Molecular Weight 469.6
    CAS Number 915019-65-7
    SMILES CC(C)(C#N)C1=CC=C(C=C1)N2C3=C4C=C(C=CC4=NC=C3N(C2=O)C)C5=CC6=CC=CC=C6N=C5

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO <1 mg/mL
    Water Insoluble
    Ethanol Warmed: 16 mg/mL (34.07 mM)
    In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.29 mL 106.47 mL 212.95 mL
    0.5 mM 4.26 mL 21.29 mL 42.59 mL
    1 mM 2.13 mL 10.65 mL 21.29 mL
    5 mM 0.43 mL 2.13 mL 4.26 mL
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