Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order

BEZ235 (NVP-BEZ235, Dactolisib)

Catalog No.: A10133

PI3K/mTOR Inhibitor

BEZ235 (NVP-BEZ235, Dactolisib)

BEZ235 (NVP-BEZ235, Dactolisib) Chemical Structure

CAS NO. 915019-65-7

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.

Availability: In stock

Package Price Qty
25 mg
50 mg
100 mg
200 mg
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Makoto Koyama, .et al. Low-dose trametinib and Bcl-xL antagonist have a specific antitumor effect in KRAS-mutated colorectal cancer cells, Int J Oncol, 2020, Sep 2 PMID: 32901840
  • Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Dominik Schulz, .et al. HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances, Am J Cancer Res, 2016, 6(9): 1963-1975 PMID: 27725902

Biological Activity

BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
Target Value
p110αIC50: 4nM
p110γIC50: 5nM
mTOR(p70S6K)IC50: 6nM
p110δIC50: 7nM
ATRIC50: 21nM
p110βIC50: 75nM
EGFR/ErbB1IC50: >8.5μM
VEGFR1/FLT1IC50: >10μM
FLT3IC50: >10μM
IGF-1RIC50: >10μM
EphB4IC50: >10μM
RETIC50: >10μM
Tie-2IC50: >10μM
c-MetIC50: >10μM
FGFR(K650E)IC50: >10μM
FAKIC50: >10μM
JAK2IC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
PKAIC50: >10μM
Akt1/PKBαIC50: >10μM
PDK-1IC50: >10μM
B-Raf(V599E)IC50: >10μM
CDK1IC50: >10μM
In vitro (25°C) DMSO <1 mg/mL
Water Insoluble
Ethanol Warmed: 16 mg/mL (34.07 mM)
In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.29 mL 106.47 mL 212.95 mL
0.5 mM 4.26 mL 21.29 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10133
Actions Inhibitor
CAS No. 915019-65-7
Formula C30H23N5O
M. Wt 469.6
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy BEZ235 (NVP-BEZ235, Dactolisib) | BEZ235 (NVP-BEZ235, Dactolisib) Supplier | purchase | cost | manufacturer | order | distributor | buy 915019-65-7| 915019-65-7 Supplier | purchase 915019-65-7 | 915019-65-7 cost | 915019-65-7 manufacturer | order 915019-65-7 | 915019-65-7 distributor